Abstract:
:Recent progress in elucidating the function of synaptonemal complex (SC) proteins and of cohesins in meiocytes made possible, in particular, through the analysis of mice deficient in SC or cohesin proteins has significantly enriched our understanding of how meiotic chromosome architecture is determined. Cohesins and the SC proteins act together in generating the characteristic axis-loop structure of meiotic chromosomes, their pairing into bivalents, their ability to recombine, and to be properly segregated. This minireview attempts to summarize the current knowledge with a focus on higher eukaryotic systems and to ask questions that ought to be addressed in the future.
journal_name
Chromosomajournal_title
Chromosomaauthors
Revenkova E,Jessberger Rdoi
10.1007/s00412-006-0060-xsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
235-40issue
3eissn
0009-5915issn
1432-0886journal_volume
115pub_type
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