Abeta-2M-amyloidosis and related bone diseases.

abstract：INTRODUCTION:This study aimed to examine long-term persistence in new users of oral bisphosphonates in a population-wide cohort in Manitoba, Canada. MATERIALS AND METHODS:A longitudinal observational study was conducted using administrative health data characterizing long-term bisphosphonate persistence in those who s...

journal_title：Journal of bone and mineral metabolism

authors： Friesen KJ,Bugden S,Falk J

更新日期：2020-05-01 00:00:00

abstract：:The prevalence and pattern of joint involvement in radiographic hand osteoarthritis (OA) have been reported in Western populations, but similar data are lacking for Japanese. We examined this issue in 551 Japanese women aged > or = 40 years. Radiographs were obtained of both hands and graded according to the Kellgren-...

journal_title：Journal of bone and mineral metabolism

authors： Toba N,Sakai A,Aoyagi K,Yoshida S,Honda S,Nakamura T

更新日期：2006-01-01 00:00:00

abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

journal_title：Journal of bone and mineral metabolism

authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

更新日期：2008-01-01 00:00:00

abstract：:Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy...

journal_title：Journal of bone and mineral metabolism

authors： Egge S,Christensen N,Lykkedegn S,Jensen TK,Christesen HT

更新日期：2018-11-01 00:00:00

abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

journal_title：Journal of bone and mineral metabolism

authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

更新日期：2015-03-01 00:00:00

abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

journal_title：Journal of bone and mineral metabolism

authors： Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

更新日期：2011-03-01 00:00:00

abstract：:Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Ishii T,Ito K,Kato S,Tsubokura M,Ochi S,Iwamoto Y,Saito Y

更新日期：2013-11-01 00:00:00

abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Oka H,Kawaguchi H,Nakamura K,Akune T

更新日期：2011-11-01 00:00:00

abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...

journal_title：Journal of bone and mineral metabolism

authors： Tamaki J,Iki M,Sato Y,Kajita E,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2010-05-01 00:00:00

abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

journal_title：Journal of bone and mineral metabolism

authors： Yao GQ,Wu JJ,Troiano N,Insogna K

更新日期：2011-03-01 00:00:00

abstract：:Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

journal_title：Journal of bone and mineral metabolism

authors： Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

更新日期：2015-01-01 00:00:00

abstract：:In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-...

journal_title：Journal of bone and mineral metabolism

authors： Zhaojun W,Lin W,Zhenyong W,Jian W,Ran L

更新日期：2013-05-01 00:00:00

abstract：:Chronic kidney disease (CKD) mineral and bone disorders (CKD-MBD) may lead to low bone mineral density (BMD) and vascular calcification (VC), but links to the latter are unclear. Here we investigated associations between BMD, coronary artery calcium (CAC) scores, and histological signs of VC in end-stage renal disease...

journal_title：Journal of bone and mineral metabolism

authors： Chen Z,Sun J,Haarhaus M,Barany P,Wennberg L,Ripsweden J,Brismar TB,Lindholm B,Wernerson A,Söderberg M,Stenvinkel P,Qureshi AR

更新日期：2017-09-01 00:00:00

abstract：:There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral ne...

journal_title：Journal of bone and mineral metabolism

authors： Wu SY,Qi J,Lu Y,Lan J,Yu JC,Wen LQ,Zhang ZL

更新日期：2010-11-01 00:00:00

abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

journal_title：Journal of bone and mineral metabolism

authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2011-03-01 00:00:00

abstract：:We previously reported that simvastatin induces estrogen receptor-alpha (ERα) in murine bone marrow stromal cells in vitro. In this study, we investigated the effect of simvastatin on ERα expression in bone and uterus in ovariectomized (OVX) rats and evaluated bone mass, bone strength, and uterine wet weight. Three-mo...

journal_title：Journal of bone and mineral metabolism

authors： Li X,Song QS,Wang JY,Leng HJ,Chen ZQ,Liu ZJ,Dang GT,Song CL

更新日期：2011-07-01 00:00:00

abstract：:The aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 ...

journal_title：Journal of bone and mineral metabolism

authors： Seok H,Kim KJ,Kim KM,Rhee Y,Cha BS,Lim SK

更新日期：2014-07-01 00:00:00

abstract：:Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testostero...

journal_title：Journal of bone and mineral metabolism

authors： Rhee EJ,Oh KW,Lee WY,Kim SW,Oh ES,Baek KH,Kang MI,Park CY,Choi MG,Yoo HJ,Park SW

更新日期：2004-01-01 00:00:00

abstract：:To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...

journal_title：Journal of bone and mineral metabolism

authors： Hojo H,Yano F,Ohba S,Igawa K,Nakajima K,Komiyama Y,Kan A,Ikeda T,Yonezawa T,Woo JT,Takato T,Nakamura K,Kawaguchi H,Chung UI

更新日期：2010-11-01 00:00:00

abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...

journal_title：Journal of bone and mineral metabolism

authors： Lee IT,Sheu WH,Tu ST,Kuo SW,Pei D

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...

journal_title：Journal of bone and mineral metabolism

authors： Cheng WZ,Lin YL,Su YC,Lin MC,Tseng CH,Lin RM,Huang ST

更新日期：2020-08-05 00:00:00

abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

journal_title：Journal of bone and mineral metabolism

authors： Hishiya A,Watanabe K

更新日期：2004-01-01 00:00:00

abstract：:Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

journal_title：Journal of bone and mineral metabolism

authors： Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

更新日期：2009-01-01 00:00:00

abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

journal_title：Journal of bone and mineral metabolism

authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

更新日期：2006-01-01 00:00:00

abstract：:Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...

journal_title：Journal of bone and mineral metabolism

authors： Ryu J,Kim H,Chang EJ,Kim HJ,Lee Y,Kim HH

更新日期：2010-07-01 00:00:00

abstract：:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, an...

journal_title：Journal of bone and mineral metabolism

authors： Yaoita H,Orimo H,Shirai Y,Shimada T

更新日期：2000-01-01 00:00:00

abstract：:There are many factors that increase the risk of osteoporosis, including smoking, malnutrition, vitamin D deficiency, hypogonadism, limited physical activity due to chronic disease, and corticosteroid therapy in chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Karadag F,Cildag O,Yurekli Y,Gurgey O

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Cold intolerance is defined as abnormal pain resulting from exposure to cold stimulation after trauma. However, the pathophysiology remains unclear. We recently demonstrated that regional osteoporotic changes accompanied by high bone turnover were involved in causing pain-like behaviors in the unloaded hin...

journal_title：Journal of bone and mineral metabolism

authors： Ibe K,Iba K,Hanaka M,Kiyomoto K,Hayakawa H,Teramoto A,Emori M,Yamashita T

更新日期：2020-07-01 00:00:00

abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...

journal_title：Journal of bone and mineral metabolism

authors： Balsa JA,Lafuente C,Gómez-Martín JM,Galindo J,Peromingo R,García-Moreno F,Rodriguez-Velasco G,Martínez-Botas J,Gómez-Coronado D,Escobar-Morreale HF,Botella-Carretero JI

更新日期：2016-11-01 00:00:00

abstract：:Knowledge of the microenvironment of articular cartilage in health and disease is the key to accomplishing fundamental disease-modifying treatments for osteoarthritis. The proteins comprising the CCN Family are matricellular proteins with a remarkable relevance within the context of cartilage metabolism. CCN2 displays...

journal_title：Journal of bone and mineral metabolism

authors： Janune D,Abd El Kader T,Aoyama E,Nishida T,Tabata Y,Kubota S,Takigawa M

更新日期：2017-11-01 00:00:00