Abstract:
:The lymphocyte profile of 521 HIV-infected subjects hospitalized at Jackson Memorial (2001-2002) was compared across main respiratory diseases. Study data included medical history and all laboratory evaluations performed during hospitalization. Community-acquired pneumonias (CAP, 52%), Pneumocystis jiroveci pneumonia (PCP, 24%), tuberculosis (TB, 9%) and non-tuberculous mycobacterial diseases (NTM, 12%) were the most frequent causes of admission. Patients hospitalized with PCP and NTM exhibited the lowest CD4 counts (P=0.003). PCP patients had the highest B-cell percentages (P=0.04). CAP patients had the highest CD8 and CD4 percentages and the lowest percentage of Natural Killer (NK) cells and viral burdens. TB patients exhibited the lowest NK-cell (11.4+/-6.3) and B-cell percentages (13.6+/-12) and the highest CD8 (59+/-14) percentage. NTM patients, in contrast, had the highest NK-cell percentages of the groups (19.1+/-11.6, P=0.01). Additionally, immune responses associated with respiratory pathogens differed in HIV-infected patients with CD4(+) cells above and below 200 counts.
journal_name
Epidemiol Infectjournal_title
Epidemiology and infectionauthors
Miguez-Burbano MJ,Ashkin D,Rodriguez A,Duncan R,Flores M,Acosta B,Quintero N,Pitchenik Adoi
10.1017/S0950268805005030subject
Has Abstractpub_date
2006-04-01 00:00:00pages
271-8issue
2eissn
0950-2688issn
1469-4409pii
S0950268805005030journal_volume
134pub_type
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