A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.

abstract：:Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurate...

journal_title：Neoplasia (New York, N.Y.)

authors： Ma MZ,Zhuang C,Yang XM,Zhang ZZ,Ma H,Zhang WM,You H,Qin W,Gu J,Yang S,Cao H,Zhang ZG

更新日期：2014-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Despite progress in identifying risk factors, the incidence of HCC is increasing. Moreover, therapeutic options are limited and survival is poor. Therefore, alternative and innovative therapeutic strategies are urgently required. R-Tf-D-LP4, a c...

journal_title：Neoplasia (New York, N.Y.)

authors： Pittala S,Krelin Y,Shoshan-Barmatz V

更新日期：2018-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths in America. Nearly two thirds of newly diagnosed CRC cases include lymph node (LN) involvement, and LN metastasis is one of the strongest negative prognostic factors for CRC. It is thought that CRC tumors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Margolin DA,Silinsky J,Grimes C,Spencer N,Aycock M,Green H,Cordova J,Davis NK,Driscoll T,Li L

更新日期：2011-09-01 00:00:00

abstract：:A noninvasive method for molecular imaging of T-cell activity in vivo would be of considerable value. It would aid in understanding the role of specific genes and signal transduction pathways in the course of normal and pathologic immune responses, and could elucidate temporal dynamics and immune regulation at differe...

journal_title：Neoplasia (New York, N.Y.)

authors： Ponomarev V,Doubrovin M,Lyddane C,Beresten T,Balatoni J,Bornman W,Finn R,Akhurst T,Larson S,Blasberg R,Sadelain M,Tjuvajev JG

更新日期：2001-11-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), a blood-borne lipid mediator, is present in elevated concentrations in ascites of ovarian cancer patients and other malignant effusions. LPA is a potent mitogen in cancer cells. The mechanism linking LPA signal to cancer cell proliferation is not well understood. Little is known about whet...

journal_title：Neoplasia (New York, N.Y.)

authors： Mukherjee A,Ma Y,Yuan F,Gong Y,Fang Z,Mohamed EM,Berrios E,Shao H,Fang X

更新日期：2015-09-01 00:00:00

abstract：:The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis. However, NCAD-mediated adhesion is a robust phenomenon and therefore seems to be inconsistent with the "release" from intercellular adhesion required for invasion. We show that in the most invasive melano...

journal_title：Neoplasia (New York, N.Y.)

authors： Maret D,Gruzglin E,Sadr MS,Siu V,Shan W,Koch AW,Seidah NG,Del Maestro RF,Colman DR

更新日期：2010-12-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait) molecules mimic DSBs and trap DNA repair proteins, thereby inhibiting repair of DNA damage induced by radiation therapy (RT). First, the cytotoxic efficacy of Dbait i...

journal_title：Neoplasia (New York, N.Y.)

authors： Biau J,Devun F,Jdey W,Kotula E,Quanz M,Chautard E,Sayarath M,Sun JS,Verrelle P,Dutreix M

更新日期：2014-10-23 00:00:00

abstract：:Identification of the cell types capable of initiating and sustaining growth of the neoplastic clone in vivo is a fundamental problem in cancer research. It is likely that tumor growth can be sustained both by rare cancer stem-like cells and selected aggressive clones and that the nature of the mutations, the cell of ...

journal_title：Neoplasia (New York, N.Y.)

authors： Tysnes BB

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND AIMS:BACKGROUND AND AIMSGemcitabine is the standard therapy for patients with pancreatic cancer with metastatic disease. Patients with metastatic pancreatic cancer presenting with increased values of C-reactive protein do not respond to gemcitabine. So far, no studies have evaluated the correlation betwe...

journal_title：Neoplasia (New York, N.Y.)

authors： Knoop RF,Sparn M,Waldmann J,Plassmeier L,Bartsch DK,Lauth M,Hudemann C,Fendrich V

更新日期：2014-06-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) belongs to the superfamily of transforming growth factor β-like cytokines, which can act either as tumor suppressors or as tumor promoters depending on cell type and differentiation. Our investigations focused on analyzing the effects of BMP-7 during glioma cell proliferation in vi...

journal_title：Neoplasia (New York, N.Y.)

authors： Klose A,Waerzeggers Y,Monfared P,Vukicevic S,Kaijzel EL,Winkeler A,Wickenhauser C,Löwik CW,Jacobs AH

更新日期：2011-03-01 00:00:00

abstract：:Bcl-2 is commonly overexpressed in tumors, where it is often associated with unfavorable outcome. However, it has also been linked to a favorable sensitivity to microtubule-targeting agents (MTAs). We show that Bcl-2-overexpressing lung and breast cancer cells were more sensitive to both paclitaxel and vinorelbine. Bc...

journal_title：Neoplasia (New York, N.Y.)

authors： Savry A,Carre M,Berges R,Rovini A,Pobel I,Chacon C,Braguer D,Bourgarel-Rey V

更新日期：2013-01-01 00:00:00

abstract：:In spite of intensive and increasingly successful attempts to determine the multiple steps involved in colorectal carcinogenesis, the mechanisms responsible for metastasis of colorectal tumors to the liver remain to be clarified. To identify genes that are candidates for involvement in the metastatic process, we analy...

journal_title：Neoplasia (New York, N.Y.)

authors： Yanagawa R,Furukawa Y,Tsunoda T,Kitahara O,Kameyama M,Murata K,Ishikawa O,Nakamura Y

更新日期：2001-09-01 00:00:00

abstract：:The present study focuses on the influence of the tumor microenvironment on the expression of HLA-G in ovarian cancer and its impact on immune cells. We used carcinomatosis fluids (n = 16) collected from patients diagnosed with epithelial ovarian cancer, detected by an increase in CA125 levels. Our results indicate th...

journal_title：Neoplasia (New York, N.Y.)

authors： Ullah M,Azazzen D,Kaci R,Benabbou N,Pujade Lauraine E,Pocard M,Mirshahi M

更新日期：2019-03-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is an important process of tumor progression associated with increased metastatic potential. EMT can be activated by external triggers such as cytokines or metabolic parameters (e.g. hypoxia). Since extracellular acidosis is a common finding in tumors, the aim of the study is...

journal_title：Neoplasia (New York, N.Y.)

authors： Riemann A,Rauschner M,Gießelmann M,Reime S,Haupt V,Thews O

更新日期：2019-05-01 00:00:00

abstract：:It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP)," characterized by preferential proximal location in the colon, but otherwise poorly defined. The...

journal_title：Neoplasia (New York, N.Y.)

authors： Anacleto C,Leopoldino AM,Rossi B,Soares FA,Lopes A,Rocha JC,Caballero O,Camargo AA,Simpson AJ,Pena SD

更新日期：2005-04-01 00:00:00

abstract：:A theoretical model for the intraperitoneal (i.p.) delivery of cisplatin and heat to tumor metastases in tissues adjacent to the peritoneal cavity is presented. The penetration distance (the depth to which drug diffuses directly from the cavity into tissues) is predicted to be on the order of 0.5 mm. The model shows t...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Kareh AW,Secomb TW

更新日期：2004-03-01 00:00:00

abstract：:The cancer stem cell paradigm postulates that dysregulated tissue-specific stem cells or progenitor cells are precursors for cancer biogenesis. Consequently, identifying cancer stem cells is crucial to our understanding of cancer progression and for the development of novel therapeutic agents. In this study, we demons...

journal_title：Neoplasia (New York, N.Y.)

authors： Vesuna F,Lisok A,Kimble B,Raman V

更新日期：2009-12-01 00:00:00

abstract：:Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. The survival for patients with glioblastoma remains dismal. While the cure rate for medulloblastoma exceeds 70%, this figure has stagnated over the past few decades and survivors still contend with s...

journal_title：Neoplasia (New York, N.Y.)

authors： Endersby R,Whitehouse J,Hii H,Greenall SA,Johns TG,Gottardo NG

更新日期：2018-05-01 00:00:00

abstract：:Conventional comparative genomic hybridization (CGH) profiling of neuroblastomas has identified many genomic aberrations, although the limited resolution has precluded a precise localization of sequences of interest within amplicons. To map high copy number genomic gains in clinically matched stage IV neuroblastomas, ...

journal_title：Neoplasia (New York, N.Y.)

authors： Beheshti B,Braude I,Marrano P,Thorner P,Zielenska M,Squire JA

更新日期：2003-01-01 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone(GH-RH)inhibit the growth of various cancers by mechanisms that involve the suppression of the insulin-like growth factor (IGF)-I and/or IGF-II. In view of the importance of the IGF system in glioma tumorigenesis, the effects of GH-RH antagonists MZ-5-156 and JV-1-36 were...

journal_title：Neoplasia (New York, N.Y.)

authors： Kiaris H,Schally AV,Varga JL

更新日期：2000-05-01 00:00:00

abstract：:Peritoneal metastasis (PM) is a very serious complication of gastrointestinal and gynecological malignancies which is poorly documented. Modified mesothelial cell layer and their microenvironments can favor fibrin deposition for cancer cell adhesion. Scanning and transmission electron microscopy of peritoneal surface ...

journal_title：Neoplasia (New York, N.Y.)

authors： Shahid S,Iman A,Matti U,Rachid K,Assaf A,Eveno C,Marc P,Massoud M

更新日期：2019-11-01 00:00:00

abstract：:The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 phosphate (CA-4-P), at selected time points after repeated intraperitonea...

journal_title：Neoplasia (New York, N.Y.)

authors： Thoeny HC,De Keyzer F,Chen F,Vandecaveye V,Verbeken EK,Ahmed B,Sun X,Ni Y,Bosmans H,Hermans R,van Oosterom A,Marchal G,Landuyt W

更新日期：2005-08-01 00:00:00

abstract：:BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAFV600E leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Unfortunately, reactiva...

journal_title：Neoplasia (New York, N.Y.)

authors： Mologni L,Costanza M,Sharma GG,Viltadi M,Massimino L,Citterio S,Purgante S,Raman H,Pirola A,Zucchetti M,Piazza R,Gambacorti-Passerini C

更新日期：2018-05-01 00:00:00

abstract：:The tumor-selective cytotoxic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) makes TRAIL an attractive candidate as an anticancer agent. However, resistance to TRAIL poses a challenge in anticancer therapy with TRAIL. Therefore, characterizing the mechanisms of resistance and developing stra...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhang L,Zhu H,Teraishi F,Davis JJ,Guo W,Fan Z,Fang B

更新日期：2005-06-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：:The progression of ovarian cancer, from cell transformation through invasion of normal tissue, relies on communication between tumor cells and their adjacent stromal microenvironment. Through a natural selection process, an autocrine-paracrine communication loop establishes reciprocal reinforcement of growth and migra...

journal_title：Neoplasia (New York, N.Y.)

authors： Schauer IG,Sood AK,Mok S,Liu J

更新日期：2011-05-01 00:00:00

abstract：:Epithelial-myoepithelial carcinoma (EMC) is a rare subtype of salivary gland neoplasms. Since the initial description of the cancer, just over 300 cases have been reported. EMCs occupy a biphasic cellular differentiation-state defined by the constitution of two cell types representing epithelial and myoepithelial line...

journal_title：Neoplasia (New York, N.Y.)

authors： Mäkelä R,Arjonen A,Suryo Rahmanto A,Härmä V,Lehtiö J,Kuopio T,Helleday T,Sangfelt O,Kononen J,Rantala JK

更新日期：2020-09-01 00:00:00

abstract：:Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRKAR1A causes enhance...

journal_title：Neoplasia (New York, N.Y.)

authors： Jones GN,Tep C,Towns WH 2nd,Mihai G,Tonks ID,Kay GF,Schmalbrock PM,Stemmer-Rachamimov AO,Yoon SO,Kirschner LS

更新日期：2008-11-01 00:00:00

abstract：:One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast and ovary. Moreover, sporadic breast tumors contain lower levels of BRCA-1 in the absence of mutations in the BRCA-1 gene. The problem of tissue specificity requires ana...

journal_title：Neoplasia (New York, N.Y.)

authors： Jeffy BD,Hockings JK,Kemp MQ,Morgan SS,Hager JA,Beliakoff J,Whitesell LJ,Bowden GT,Romagnolo DF

更新日期：2005-09-01 00:00:00