Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines.

Abstract:

BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expression in 4 different human breast cancer cell lines, representative of different histotypes of breast cancer. METHODS:MCF-7, T-47D, MDA-MB231, and HCC-1937 (the latter carrying the BRCA-1 mutation) were exposed to different stimulators and the levels of NIS and LPO mRNA measured by a quantitative RT-PCR. RESULTS:All-trans-Retinoic Acid (RA), Dexamethasone (DEX), Trichostatin A (TSA), and Sodium Butyrate (NaB) induced the expression of NIS mRNA in MCF-7 and T-47D cell lines, whereas HCC-1937 and MBA-MB231 were slightly responsive only to the histone-deacetylase inhibitors TSA and NaB. Minor stimulatory effects were detected on LPO mRNA in MCF-7 and T-47D treated with TSA and NaB or RA only in MCF-7, while no effect was detectable in the other two cell lines. CONCLUSIONS:These data indicate that retinoic acid, alone or in combination with DEX, as well as HDAC-inhibitors are very promising agents for a radioiodine- based therapy in a large spectrum of breast cancers, including neoplasms from both basal and ductal cells, especially for the well-differentiated estrogen-dependent tumors. Other molecules or other drug combinations should be tested to extend the same strategy to the less differentiated and more aggressive tumor cells, including those carrying the BRCA mutation.

journal_name

J Endocrinol Invest

authors

Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

doi

10.1007/BF03346542

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

2-6

issue

1

eissn

0391-4097

issn

1720-8386

pii

6522

journal_volume

33

pub_type

杂志文章
  • Silver-Russell syndrome and its genetic origins.

    abstract::Silver-Russell syndrome (SRS) is both clinically and genetically a heterogeneous congenital disorder. Patients are characterised by severe intrauterine and post-natal growth retardation, dysmorphic facial features and, asymmetry. Various chromosome abnormalities have been associated with the disease, involving most of...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Rossignol S

    更新日期:2006-01-01 00:00:00

  • Glucose metabolism during ghrelin infusion in patients with anorexia nervosa.

    abstract::Anorexia nervosa (AN) is an eating disorder characterized by self-induced starvation due to fear of adiposity. Ghrelin, gastric peptide with potent orexigenic, adipogenic, GH-releasing and metabolic properties, is elevated in AN. We have previously shown that intervention with exogenous ghrelin is not effective in ter...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350816

    authors: Miljic D,Djurovic M,Pekic S,Doknic M,Stojanovic M,Milic N,Casanueva FF,Ghatei M,Popovic V

    更新日期:2007-10-01 00:00:00

  • Small fibers peroneal mononeuropathy in a patient with Sjögren's syndrome.

    abstract::Sjögren's syndrome (SS) is an autoimmune epithelitis characterized by lymphocytic infiltration of exocrine glands and epithelia in multiple sites. One third of the patients present with peripheral nervous system involvement. We describe the case of a woman aged 62 affected by a peroneal nerve mononeuropathy with painf...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:

    authors: Pavesi G,Cattaneo L,Chierici E,Marbini A,Sasso E,Mancia D

    更新日期:2004-01-01 00:00:00

  • Synthetic growth hormone-releasing hormone (GHRH 1-44) in the differential diagnosis between hypothalamic and pituitary GH deficiency.

    abstract::GH response to an iv bolus of growth-hormone-releasing hormone (GHRH 1-44, 2 micrograms/kg iv) was evaluated in 17 prepubertal children with total GH deficiency (GHD), 6 with partial GHD and in 7 prepubertal normal but short children tested as control. GH response to conventional pharmacological (insulin and arginine ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03346976

    authors: Bozzola M,Tatò L,Cisternino M,Nava C,Valtorta A,Chiesa M,Severi F,Gaburro D

    更新日期:1986-12-01 00:00:00

  • Prolactin secretion in pubertal and adult male subjects.

    abstract::Prolactin, LH and FSH circadian secretion were studied in a group of 20 boys in various pubertal stages and in 13 normal male adults. Prolactin 24-hour integrated concentration was similar in all groups except in stage 2 boys, in which it was significantly higher with respect to stage 3-4 boys. This pattern was observ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348421

    authors: Minuto F,Barreca A,Ferrini S,Del Monte P,Bernasconi D,Giordano G

    更新日期:1984-06-01 00:00:00

  • New achievement and novel therapeutic applications of PDE5 inhibithors in older males.

    abstract::Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Frajese GV,Pozzi F

    更新日期:2005-01-01 00:00:00

  • Longitudinal study on goiter prevalence and goitrogen factors in northeastern Sicily.

    abstract::A longitudinal study was carried out in an area of endemic goiter of north-eastern Sicily. Three different surveys (in 1977, 1983 and 1994) evaluated the epidemiological prevalence of goiter in schoolchildren of the endemic area (towns of Bronte, Troina and Maniaci) in comparison to an iodine sufficient control area (...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349031

    authors: Regalbuto C,Squatrito S,La Rosa GL,Cercabene G,Ippolito A,Tita P,Salamone S,Vigneri R

    更新日期:1996-10-01 00:00:00

  • Perindopril attenuates renal tubulointerstitium injury by inhibiting scavenger receptor A over-expression in diabetic rats.

    abstract::Scavenger receptor A (SR-A) is the main receptor through which oxidized LDL (oxLDL) and advanced glycation end products get into the cells. The aim of the present study was to investigate the effect of an ACE inhibitor, perindopril, on the expression of SR-A in renal tubulointerstitium of diabetic rats. Diabetes was i...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/7867

    authors: Sun L,Wen JH,Sun HL,Shu XC,Hu F,Yin DC,Yang Q,Zeng YJ,Sun Y,Liu L

    更新日期:2012-05-01 00:00:00

  • Effect of neonatal hypothyroidism on carbohydrate metabolism, insulin secretion, and pancreatic islets morphology of adult male offspring in rats.

    abstract:BACKGROUND:Neonatal hypothyroidism has serious effects on growth, development, and metabolism. AIM:This study aims to investigate the effects of the neonatal hypothyroidism on carbohydrate metabolism, islet insulin secretion and morphology of the pancreatic islets in adult male offspring. MATERIALS/SUBJECTS AND METHO...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8468

    authors: Farahani H,Ghasemi A,Roghani M,Zahediasl S

    更新日期:2013-01-01 00:00:00

  • Functional anatomy of the human vagina.

    abstract::Anatomy studies normally precede physiology. While the anatomy of the penis and the biochemical and molecular regulation of erection are largely known, the exact anatomical description of the human clitoris was produced in 1998, the taxonomy of female sexual dysfunctions classified in 1999, and biochemistry of female ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:

    authors: D'Amati G,di Gioia CR,Proietti Pannunzi L,Pistilli D,Carosa E,Lenzi A,Jannini EA

    更新日期:2003-01-01 00:00:00

  • Endemic goiter in Morocco (Skoura-Toundoute areas in the high atlas).

    abstract::Endemic goiter in Morocco is localized in the Rif and Atlas mountains. In this study, performed in the Skoura-Toundoute areas (high Atlas), we demonstrate that iodine deficiency is the main factor involved in the development of endemic goiter. However it may not constitute the only etiological factor. The median urina...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345821

    authors: Aquaron R,Zarrouck K,el Jarari M,Ababou R,Talibi A,Ardissone JP

    更新日期:1993-01-01 00:00:00

  • Metabolic syndrome is the key determinant of impaired vaginal lubrication in women with chronic spinal cord injury.

    abstract:PURPOSE:Spinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01185-w

    authors: D'Andrea S,Castellini C,Paladino V,Totaro M,Felzani G,Francavilla S,Francavilla F,Barbonetti A

    更新日期:2020-07-01 00:00:00

  • Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance.

    abstract:BACKGROUND:Non-exercise activity thermogenesis has recently drawn attention because of its potential to prevent weight gain. AIM:This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance (IR) in the Japanese population....

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/9066

    authors: Uemura H,Katsuura-Kamano S,Yamaguchi M,Nakamoto M,Hiyoshi M,Arisawa K

    更新日期:2013-12-01 00:00:00

  • Biphasic insulin aspart 30: better glycemic control than with premixed human insulin 30 in obese patients with Type 2 diabetes.

    abstract:AIM:This 3-month study compared the effect on overall glycemic control of adding biphasic insulin aspart 30 (BIAsp30) and premixed human insulin 30/70 (BHI30) to metformin (met) in insulin-naïve, obese patients (30 males/20 females) with Type 2 diabetes (T2DM). MATERIAL/SUBJECTS: At baseline, patients had a mean age of...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345673

    authors: Velojic-Golubovic M,Mikic D,Pesic M,Dimic D,Radenkovic S,Antic S

    更新日期:2009-01-01 00:00:00

  • Somatostatin-related therapeutics in ophthalmology: a review.

    abstract::Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled s...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Missotten T,Baarsma GS,Kuijpers RW,van den Born LI,van der Loos T,Croxen R,Hofland LJ,van Hagen PM

    更新日期:2005-01-01 00:00:00

  • Lipid profile and nutritional intake in children and adolescents with Type 1 diabetes improve after a structured dietician training to a Mediterranean-style diet.

    abstract:AIM:To evaluate if nutritional intakes and lipid profile fulfill international guidelines and recommendations before and after a structured dietician training to a Mediterranean- style diet in an Italian pediatric population with Type 1 diabetes. METHODS:A 6-month prospective cohort study. Baseline and after-intervent...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.3275/7755

    authors: Cadario F,Prodam F,Pasqualicchio S,Bellone S,Bonsignori I,Demarchi I,Monzani A,Bona G

    更新日期:2012-02-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract:BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0875-3

    authors: Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期:2019-01-01 00:00:00

  • Metastatic thyroid carcinoma of the adrenal gland.

    abstract::Follicular thyroid carcinoma may spread distant metastases in sites such as bone, lung and brain. In our series of 448 patients with follicular thyroid carcinoma, distant metastases were present in 25% of cases. We report here a case of follicular thyroid carcinoma with a single metastasis at the right adrenal gland, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347667

    authors: Girelli ME,Casara D,Rubello D,Piccolo M,Piotto A,Pelizzo MR,Busnardo B

    更新日期:1993-02-01 00:00:00

  • Puberty onset in Northern Italy: a random sample of 3597 Italian children.

    abstract::Entering puberty is one of the most important milestones in life. Studies from around the world have shown that age of pubertal changes onset can vary with race and ethnicity, environmental conditions, geographical location and nutrition. In the last century, the onset of puberty progressively shifted back towards you...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347256

    authors: Castellino N,Bellone S,Rapa A,Vercellotti A,Binotti M,Petri A,Bona G

    更新日期:2005-07-01 00:00:00

  • Hormonal and metabolic changes in starving obese patients during exhaustive physical exercise.

    abstract::Exhaustive graded exercise leads to changes of hormones, carbohydrate, and lipid metabolism in normal controls and obese patients after prolonged starvation. Concomitant with a large increase of plasma catecholamines, insulin concentration is reduced and blood glucose levels slowly increase. More glucose is made avail...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348344

    authors: Jakober B,Schmülling RM,Müller PH,Eggstein M

    更新日期:1983-12-01 00:00:00

  • Ectopic aldosteronoma associated to another adrenocortical adenoma in the adrenal gland of the same side.

    abstract::The occurrence of tumors originating from aberrant adrenocortical tissue in ectopic site is very rare. Up to now only two cases of ectopic aldosterone-producing adenoma have been described. We have observed another case of ectopic aldosteronoma, located in the retrocaval region, laterally to the body of the 12th thora...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349816

    authors: Mazza E,Papotti M,Durando R,Robecchi A,Camanni F

    更新日期:1995-11-01 00:00:00

  • The effect of short-term growth hormone or low-dose oxandrolone treatment in boys with constitutional growth delay.

    abstract::We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po)....

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03347908

    authors: Loche S,Pintor C,Cambiaso P,Lampis A,Carta D,Corda R,Cappa M

    更新日期:1991-10-01 00:00:00

  • Colonic polyps of acromegalic patients are not associated with mutations of the peroxisome proliferator activated receptor gamma gene.

    abstract::Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03345249

    authors: Bogazzi F,Ultimieri F,Raggi F,Russo D,Brogioni S,Cosci C,Gasperi M,Costa A,Viacava P,Mosca F,Bartalena L,Martino E

    更新日期:2003-11-01 00:00:00

  • Effect of alpha-1-blockade by prazosin on blood sugar, insulin and glucagon levels in normals and non-insulin dependent diabetics.

    abstract::The AA. studied the glycometabolic activity of prazosin, a hypotensive drug with an adrenergic blocking activity of alpha-1-selective type. Twenty-two moderately hypertensive subjects were studied. Their ages ranged from 37 to 57 years; 10 of the patients had non-insulin dependent diabetes mellitus. After overnight fa...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03350608

    authors: Ferlito S,Puleo F,Carrà G,Damante G,Di Vincenzo S,Del Campo F

    更新日期:1983-06-01 00:00:00

  • Effects of salmon calcitonin on blood glucose and insulin levels under basal conditions and after intravenous glucose load.

    abstract::A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349315

    authors: Petralito A,Lunetta M,Liuzzo A,Fiore CE,Heynen G

    更新日期:1979-04-01 00:00:00

  • A reappraisal of the role of methimazole and other factors on the efficacy and outcome of radioiodine therapy of Graves' hyperthyroidism.

    abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348615

    authors: Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

    更新日期:1990-06-01 00:00:00

  • Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism.

    abstract::The pituitary and peripheral responses to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset hypothyroidism, after they had had their chronic thyroid hormon...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348554

    authors: Cavaliere H,Medeiros-Neto GA,Rosner W,Kourides IA

    更新日期:1985-12-01 00:00:00

  • The effect of hormone replacement therapy in postmenopausal women on urinary C-telopeptide and N-telopeptide of type I collagen, new markers of bone resorption.

    abstract::To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347294

    authors: Taga M,Uemura T,Minaguchi H

    更新日期:1998-03-01 00:00:00

  • Comparison of immuno- and HPLC-assays for the measurement of urinary collagen cross-links.

    abstract::Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349673

    authors: Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

    更新日期:1994-09-01 00:00:00

  • Dyshormonogenetic goiter: presence of an inhibitor of normal human thyroid peroxidase.

    abstract::A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349651

    authors: Rosenthal D,Carvalho-Guimarães DP,Knobel M,Medeiros-Neto GA

    更新日期:1990-12-01 00:00:00