Effects of omega-3 polyunsaturated fatty acids on inflammatory markers in COPD.

Abstract:

BACKGROUND:COPD, the fifth-leading cause of death worldwide, is characterized by chronic inflammation. However, no available agent can effectively cure this inflammation. A dietary supplement containing omega-3 polyunsaturated fatty acids (PUFAs) has anti-inflammatory effects. In this study, we hypothesized that nutritional support with omega-3 PUFA-rich diets may be useful for treating COPD, and we compared the clinical features and inflammatory mediator levels between the COPD patients who received an omega-3 PUFA-rich supplement and those who received a nonrich supplement. METHODS:Sixty-four COPD patients received 400 kilocalories per day of an omega-3 PUFA-rich supplement (n-3 group) or an omega-3 PUFA-nonrich supplement (n-6 group) for 2 years. We prospectively investigated the clinical features of these patients and measured the levels of inflammatory mediators. RESULTS:In 6-min walk testing, the dyspnea Borg scale and decrease of arterial oxygen saturation measured by pulse oximetry significantly improved in the n-3 group. Leukotriene B4 levels in serum and sputum and tumor necrosis factor-alpha and interleukin-8 levels in sputum decreased significantly in the n-3 group, while there was no significant change in the n-6 group. Two patients in the n-3 group and three patients in the n-6 group had mild diarrhea, and three patients in the n-3 group and three patients in the n-6 group had nausea; however, their symptoms were controllable and they improved with treatment. With multiple regression analysis, it was proved that the omega-3 PUFA-rich diet significantly contributed to the change in cytokine levels in this study. CONCLUSION:We suggest nutritional support with an omega-3 PUFA-rich diet as a safe and practical method for treating COPD.

journal_name

Chest

journal_title

Chest

authors

Matsuyama W,Mitsuyama H,Watanabe M,Oonakahara K,Higashimoto I,Osame M,Arimura K

doi

10.1378/chest.128.6.3817

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

3817-27

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)49623-0

journal_volume

128

pub_type

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