The Tennessee Mouse Genome Consortium: identification of ocular mutants.

abstract：:Experiments on the lateral geniculate nucleus (LGN) of the cat based on 14C 2-deoxyglucose (2-DG) autoradiography and intraocular injections of 2-amino-4-phosphonobutyric acid (APB) provided evidence for gradients of metabolic activity in the ON and OFF pathways in layer A, but only very weakly, if at all, in layer A1...

journal_title：Visual neuroscience

authors： Thurlow GA,Bowling DB,Cooper RM

更新日期：1993-11-01 00:00:00

abstract：:The phosphoinositide (PI) intracellular signaling pathway, which triggers Ca2+ release from intracellular stores, appears to be a central feature of phototransduction in most invertebrate species studied. Procedures designed to inhibit PI-pathway reactions cause suppression of excitation to dim lights. However, in Lim...

journal_title：Visual neuroscience

authors： Johnson EC,Gray-Keller MP,O'Day PM

更新日期：1998-01-01 00:00:00

abstract：:AMPA-selective glutamate receptors play a major role in glutamatergic neurotransmission in the retina and are expressed in a variety of neuronal subpopulations. In the present study, immunocytochemical techniques were used to visualize the distribution of GluR2 and GluR4 subunits in the cat retina. Results were compar...

journal_title：Visual neuroscience

authors： Qin P,Pourcho RG

更新日期：1999-11-01 00:00:00

abstract：:Dark-adapted rods exert a tonic suppressive influence upon cone-mediated sensitivity to rapid flicker, a phenomenon called suppressive rod-cone interaction (SRCI). However, rod dark adaptation has negligible influence upon cone-mediated thresholds measured with more usual psychophysical procedures. The present study s...

journal_title：Visual neuroscience

authors： Frumkes TE,Lange G,Denny N,Beczkowska I

更新日期：1992-02-01 00:00:00

abstract：:Lesion or inactivation of the superior colliculus (SC) of the cat results in an animal that fails to orient toward peripheral visual stimuli which normally evoke a brisk, reflexive orienting response. A failure to orient toward a visual stimulus could be the result of a sensory impairment (a failure to detect the visu...

journal_title：Visual neuroscience

authors： Fitzmaurice MC,Ciaramitaro VM,Palmer LA,Rosenquist AC

更新日期：2003-11-01 00:00:00

abstract：:Monocular deprivation (MD) by lid suture is one of the classic paradigms for the study of developmental plasticity in the cerebral cortex, and we have detailed knowledge of its anatomical and physiological consequences as well as underlying molecular and cellular mechanisms. However, the effects of other forms of mani...

journal_title：Visual neuroscience

authors： Jaffer S,Vorobyov V,Sengpiel F

更新日期：2012-09-01 00:00:00

abstract：:Observers performed red-green and yellow-blue hue cancellation tasks for a 0.8-deg circular test field on a dark surround, by manipulating the excitation level of one cone class while the other two classes were held constant. The results of the red-green judgments conformed to classical opponent color theory in that b...

journal_title：Visual neuroscience

authors： Knoblauch K,Shevell SK

更新日期：2001-11-01 00:00:00

abstract：:During early mammalian development, inputs from the two retinas intermix within the lateral geniculate nucleus (LGN), then segregate during the first postnatal week into layers that receive input from a single retina. Functionally, the LGN also changes markedly during the first postnatal month; early geniculate respon...

journal_title：Visual neuroscience

authors： Cook PM,Prusky G,Ramoa AS

更新日期：1999-05-01 00:00:00

abstract：:Within the visual cortex of several mammalian species, more circuitry is devoted to the representation of vertical and horizontal orientations than oblique orientations. The sensitivity of this representation of orientation preference to visual experience during cortical maturation and the overabundance of cardinal co...

journal_title：Visual neuroscience

authors： Coppola DM,White LE

更新日期：2004-01-01 00:00:00

abstract：:Studies of the numbers of retinal ganglion cells and lateral geniculate nucleus (LGN) neurons in primates suggest that the numbers of both types of neurons may vary over a two-fold range from one individual to another. This raises the question of whether the numbers of ganglion cells and LGN neurons are related or var...

journal_title：Visual neuroscience

authors： Spear PD,Kim CB,Ahmad A,Tom BW

更新日期：1996-01-01 00:00:00

abstract：:The spatial and temporal interactions in the receptive fields of On-Off directionally selective (DS) ganglion cells endow them with directional selectivity. Using a variety of stimuli, such as sinusoidal gratings, we show that these interactions make directional selectivity of the DS ganglion cell robust with respect ...

journal_title：Visual neuroscience

authors： Grzywacz NM,Amthor FR

更新日期：2007-07-01 00:00:00

abstract：:Although galvanic vestibular stimulation (GVS) is known to affect the speed and accuracy of visual judgments, the underlying electrophysiological response has not been explored. In the present study, we therefore investigated the effect of GVS on the N170 event-related potential, a marker commonly associated with earl...

journal_title：Visual neuroscience

authors： Wilkinson D,Ferguson HJ,Worley A

更新日期：2012-09-01 00:00:00

abstract：:This paper reviews evidence that the superior colliculus (SC) of the midbrain represents visual direction and certain aspects of saccadic eye movements in the distribution of activity across a population of cells. Accurate and precise eye movements appear to be mediated, in part at least, by cells of the SC that have ...

journal_title：Visual neuroscience

authors： McIlwain JT

更新日期：1991-01-01 00:00:00

abstract：:For over 30 years there has been a controversy over whether color-defined motion can be perceived by the human visual system. Some results suggest that there is no chromatic motion mechanism at all, whereas others do find evidence for a purely chromatic motion mechanism. Here we examine the chromatic input to global m...

journal_title：Visual neuroscience

authors： Ruppertsberg AI,Wuerger SM,Bertamini M

更新日期：2003-07-01 00:00:00

abstract：:We examined the grating acuity and contrast sensitivity of cats whose eye position was monitored with a scleral search-coil technique. During each trial, the cat was required to maintain fixation on a laser spot and respond to the presence or the absence of a grating by pressing a right or left pedal. With this proced...

journal_title：Visual neuroscience

authors： Pasternak T,Horn K

更新日期：1991-02-01 00:00:00

abstract：:Human, macaque monkey, and rat retinas were immunostained with a polyclonal antibody preparation against purified recoverin, a 23-kD calcium-binding protein isolated from bovine retina that localizes to rods and cones (Dizhoor et al., 1991). In addition to immunoreactive photoreceptors, we have identified subpopulatio...

journal_title：Visual neuroscience

authors： Milam AH,Dacey DM,Dizhoor AM

更新日期：1993-01-01 00:00:00

abstract：:We examine the assumptions that the fovea contains equal numbers of inner (invaginating or ON) and outer (flat or OFF) midget bipolar cells and equal numbers of inner and outer diffuse bipolar cells. Based on reconstruction from electron photomicrographs of serial thin sections through the fovea of a macaque monkey, w...

journal_title：Visual neuroscience

authors： Ahmad KM,Klug K,Herr S,Sterling P,Schein S

更新日期：2003-03-01 00:00:00

abstract：:We examined achromatic contrast discrimination in asymptomatic carriers of 11778 Leber's hereditary optic neuropathy (LHON 18 controls) and 18 age-match were also tested. To evaluate magnocellular (MC) and Parvocellular (PC) contrast discrimination, we used a version of Pokorny and Smith's (1997) pulsed/steady-pedesta...

journal_title：Visual neuroscience

authors： Gualtieri M,Bandeira M,Hamer RD,Costa MF,Oliveira AG,Moura AL,Sadun F,De Negri AM,Berezovsky A,Salomão SR,Carelli V,Sadun AA,Ventura DF

更新日期：2008-05-01 00:00:00

abstract：:Several lines of evidence indicate that retinal photoreceptors produce melatonin. However, there are other potential melatonin sources in the retina, and melatonin synthesis can be regulated by feedback from the inner retina. To analyze cellular mechanisms of melatonin regulation in retinal photoreceptors, we have dev...

journal_title：Visual neuroscience

authors： Cahill GM,Besharse JC

更新日期：1992-05-01 00:00:00

abstract：:One type of retinal ganglion cells prefers object motion in a particular direction. Neuronal mechanisms for the computation of motion direction are still unknown. We quantitatively mapped excitatory and inhibitory regions of receptive fields for directionally selective retinal ganglion cells in the Japanese quail, and...

journal_title：Visual neuroscience

authors： Uchiyama H,Kanaya T,Sonohata S

更新日期：2000-03-01 00:00:00

abstract：:The aim of this study was to determine whether agmatine, a channel permeable probe, can identify photoreceptor dysfunction in the Royal College of Surgeons (RCS) retina at an earlier stage to that shown by apoptosis or anatomical markers, and also characterize the neurochemical development of the inner retina in the n...

journal_title：Visual neuroscience

authors： Kalloniatis M,Tomisich G,Wellard JW,Foster LE

更新日期：2002-01-01 00:00:00

abstract：:Receptive field organization of cone-driven bipolar cells was investigated by intracellular recording in the intact light-adapted retina of the tiger salamander (Ambystoma tigrinum). Centered spots and concentric annuli of optimum dimensions were used to selectively stimulate the receptive field center and surround wi...

journal_title：Visual neuroscience

authors： Burkhardt DA,Bartoletti TM,Thoreson WB

更新日期：2011-05-01 00:00:00

abstract：:The modulatory influence of pretectal neurons on retino-geniculate transmission in the cat was studied by cross-correlation analysis of single-unit activity simultaneously recorded from the dorsal lateral geniculate nucleus (dLGN) and the pretectum (PT) and with reversible inactivation of the PT by GABA microiontophor...

journal_title：Visual neuroscience

authors： Funke K,Eysel UT

更新日期：1995-01-01 00:00:00

abstract：:To investigate the influence of voltage-sensitive conductances in shaping light-evoked responses of retinal bipolar cells, whole-cell recordings were made in the slice preparation of the tiger salamander, Ambystoma tigrinum. To study contrast encoding, the retina was stimulated with 0.5-s steps of negative and positiv...

journal_title：Visual neuroscience

authors： Thoreson WB,Burkhardt DA

更新日期：2003-01-01 00:00:00

abstract：:Effects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 microM, up to about 100%), in 33%. ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed si...

journal_title：Visual neuroscience

authors： Watanabe S,Shen J

更新日期：1997-07-01 00:00:00

abstract：:Adult teleost fish retinas can regenerate neurons following either surgical or pharmacological injury. The cellular milieu of the damaged retina within which regenerated neurons are produced might be different in these two model systems of retinal injury, and thus the phenotypic attributes of regenerated neurons in th...

journal_title：Visual neuroscience

authors： Cameron DA,Powers MK

更新日期：2000-07-01 00:00:00

abstract：:Much of what is currently known about the visual response of retinal bipolar cells is based on studies of rod-dominant responses to flashes in the dark in the isolated retina. This minireview summarizes quantitative findings on contrast processing in the intact light-adapted retina based on intracellular recording fro...

journal_title：Visual neuroscience

authors： Burkhardt DA

更新日期：2011-01-01 00:00:00

abstract：:Synaptically localized calcium channels shape the timecourse of synaptic release, are a prominent site for neuromodulation, and have been implicated in genetic disease. In retina, it is well established that L-type calcium channels play a major role in mediating release of glutamate from the photoreceptors and bipolar...

journal_title：Visual neuroscience

authors： Bieda MC,Copenhagen DR

更新日期：2004-07-01 00:00:00

abstract：:There are four cone morphologies in zebrafish, corresponding to UV (U), blue (B), green (G), and red (R)-sensing types; yet genetically, eight cone opsins are expressed. How eight opsins are physiologically siloed in four cone types is not well understood, and in larvae, cone physiological spectral peaks are unstudied...

journal_title：Visual neuroscience

authors： Nelson RF,Balraj A,Suresh T,Torvund M,Patterson SS

更新日期：2019-07-30 00:00:00

abstract：:Eye growth and refraction are regulated by visual processing in the retina. Until now, the messengers released by the retina to induce these changes are largely unknown. Previously, it was found that glucagon amacrine cells respond to defocus in the retinal image and even to its sign. The expression of the immediate-e...

journal_title：Visual neuroscience

authors： Feldkaemper MP,Schaeffel F

更新日期：2002-11-01 00:00:00