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Synthesis of Abyssinone II and related compounds as potential chemopreventive agents.

Abstract：

:A facile and efficient approach to the synthesis of prenylated flavonoids as potential chemopreventive agents has been described. This features the synthesis of prenyl halide, prenylation of p-hydroxybenzaldehyde, formation of prenylated polyhydroxychalcone and cyclization of prenylated polyhydroxychalcone to flavanones (15) and (16), and flavonol (17) starting from isoprene (1). The structures of all three compounds have been characterized by NMR, IR and mass spectroscopy.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Moriarty RM,Grubjesic S,Surve BC,Chandersekera SN,Prakash O,Naithani R

doi

10.1016/j.ejmech.2005.09.008

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

263-7

issue

2

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(05)00270-9

journal_volume

41

pub_type

杂志文章

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