Mouse models of transforming growth factor beta impact in breast development and cancer.

abstract：:Endometrial cancer risk is strongly influenced by obesity, but the mechanisms of action remain unclear. Leptin and adiponectin, secreted from adipose tissue, reportedly play a role in such carcinogenic processes as cell proliferation, angiogenesis, and insulin regulation. In this case-control study, nested within the ...

journal_title：Endocrine-related cancer

authors： Dallal CM,Brinton LA,Bauer DC,Buist DS,Cauley JA,Hue TF,Lacroix A,Tice JA,Chia VM,Falk R,Pfeiffer R,Pollak M,Veenstra TD,Xu X,Lacey JV Jr,B~FIT Research Group.

更新日期：2013-02-18 00:00:00

abstract：:This review focuses on the tumour types and symptoms associated with non-islet cell tumour-induced hypoglycaemia (NICTH) as well as the pathogenesis, diagnosis and treatment of this rare paraneoplastic phenomenon. In addition, we report two illustrative cases of patients suffering from NICTH caused by a solid fibrous ...

journal_title：Endocrine-related cancer

authors： de Groot JW,Rikhof B,van Doorn J,Bilo HJ,Alleman MA,Honkoop AH,van der Graaf WT

更新日期：2007-12-01 00:00:00

abstract：:Quantitative reverse transcription-polymerase chain reaction (RT-PCR) used to detect minor changes in specific mRNA concentrations may be associated with poor reproducibility. Stringent quality control is therefore essential at each step of the protocol, including the PCR procedure. We performed inter-laboratory quali...

journal_title：Endocrine-related cancer

authors： de Cremoux P,Bieche I,Tran-Perennou C,Vignaud S,Boudou E,Asselain B,Lidereau R,Magdelénat H,Becette V,Sigal-Zafrani B,Spyratos F

更新日期：2004-09-01 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor st...

journal_title：Endocrine-related cancer

authors： Mertens F,Gremeaux L,Chen J,Fu Q,Willems C,Roose H,Govaere O,Roskams T,Cristina C,Becú-Villalobos D,Jorissen M,Poorten VV,Bex M,van Loon J,Vankelecom H

更新日期：2015-08-01 00:00:00

abstract：:The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation of this gland. In a recent whole-genome approach, exploiting a pituitary tumour cell line, we identified hypermethylation associated loss of NNAT. In this repo...

journal_title：Endocrine-related cancer

authors： Revill K,Dudley KJ,Clayton RN,McNicol AM,Farrell WE

更新日期：2009-06-01 00:00:00

abstract：:We report the case of an 8-year-old child who presented with severe hyperinsulinaemic hypoglycaemia due to a pancreatic islet cell adenoma. In vivo, there was no beneficial response to the hyperglycaemia-inducing agent diazoxide and as a consequence the child underwent a subtotal pancreatectomy. In vitro studies of ad...

journal_title：Endocrine-related cancer

authors： Hussain K,Cosgrove KE,Shepherd RM,Chapman JC,Swift SM,Smith VV,Kassem SA,Glaser B,Lindley KJ,Aynsley-Green A,Dunne MJ

更新日期：2002-12-01 00:00:00

abstract：:Apoptosis is a frequent phenomenon in breast cancer and it can be detected by light microscopy in conventional histopathological sections or by special staining techniques. The number of apoptotic cells as a percentage of cells present, or the number of apoptotic cells per square millimetre of neoplastic tissue, is us...

journal_title：Endocrine-related cancer

authors： Lipponen P

更新日期：1999-03-01 00:00:00

abstract：:Imatinib mesylate (IM), a small molecule that is a selective inhibitor of the ABL, platelet derived growth factor receptor (PDGFR-R) and stem cell ligand receptor (c-kit) tyrosine kinases (TK). IM was also found to inhibit the TK activity of BCR/ABL fusion protein produced in chronic myelogenous leukemia, with marked ...

journal_title：Endocrine-related cancer

authors： Gross DJ,Munter G,Bitan M,Siegal T,Gabizon A,Weitzen R,Merimsky O,Ackerstein A,Salmon A,Sella A,Slavin S,Israel Glivec in Solid Tumors Study Group.

更新日期：2006-06-01 00:00:00

abstract：:Pheochromocytomas are catecholamine-producing tumors which are generally benign, but which can also present as or develop into malignancy. Molecular pathways of malignant transformation remain poorly understood. Pheochromocytomas express various trophic peptides which may influence tumoral cell behavior. Here, we inve...

journal_title：Endocrine-related cancer

authors： Thouënnon E,Pierre A,Tanguy Y,Guillemot J,Manecka DL,Guérin M,Ouafik L,Muresan M,Klein M,Bertherat J,Lefebvre H,Plouin PF,Yon L,Anouar Y

更新日期：2010-06-25 00:00:00

abstract：:Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechani...

journal_title：Endocrine-related cancer

authors： Huang Y,Jin H,Liu Y,Zhou J,Ding J,Cheng KW,Yu Y,Feng Y

更新日期：2010-11-30 00:00:00

abstract：:Thyroid cancer is the most frequent endocrine tumor with a growing incidence worldwide. However, common diagnostic strategy for thyroid cancer classification is hardly to make a proper diagnosis in some cases. To assist classical approach, this study used metabolomics to screen and validate biomarkers from serum and u...

journal_title：Endocrine-related cancer

authors： Chen J,Hu Q,Hou H,Wang S,Zhang Y,Luo Y,Chen H,Deng H,Zhu H,Zhang L,Liu H,Wang A,Liu Y

更新日期：2019-12-01 00:00:00

abstract：:Resistance to anoikis (matrix deprivation-induced apoptosis) is a critical component of the metastatic cascade. Molecular mechanisms underlying resistance to anoikis have not been reported in thyroid cancer cells. For an in vitro model of anoikis, we cultured follicular, papillary, and anaplastic thyroid cancer cell l...

journal_title：Endocrine-related cancer

authors： Jensen K,Patel A,Klubo-Gwiezdzinska J,Bauer A,Vasko V

更新日期：2011-09-20 00:00:00

abstract：:With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid...

journal_title：Endocrine-related cancer

authors： Shulan JM,Vydro L,Schneider AB,Mihailescu DV

更新日期：2018-04-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1 (IRS-1) and IRS-2 are multisite docking proteins positioned immediately downstream from the type I IGF and insulin receptors. IRS-2 but not IRS-1 has been repo...

journal_title：Endocrine-related cancer

authors： de Blaquière GE,May FE,Westley BR

更新日期：2009-06-01 00:00:00

abstract：:Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-cells and can occur either as sporadic or as hereditary diseases in the context of familial syndromes, including multiple endocrine neoplasia 2A (MEN2A), multiple endocrine neoplasia 2B (MEN2B) and familial MTC (FMTC). In a la...

journal_title：Endocrine-related cancer

authors： Castellone MD,Melillo RM

更新日期：2018-02-01 00:00:00

abstract：:The central involvement of estrogen in the development of the mammary gland and in the genesis of breast cancer has lent impetus to studies of the links between estrogen action and the cell cycle machinery. Recent studies of the estrogenic regulation of molecules with known roles in the control of G1/S phase progressi...

journal_title：Endocrine-related cancer

authors： Doisneau-Sixou SF,Sergio CM,Carroll JS,Hui R,Musgrove EA,Sutherland RL

更新日期：2003-06-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness. The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). In TIO, FGF23 is secret...

journal_title：Endocrine-related cancer

authors： Chong WH,Molinolo AA,Chen CC,Collins MT

更新日期：2011-06-08 00:00:00

abstract：:Transformation-related protein 63 (Trp63), the predominant member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia. Trp63 features two distinct promoters yielding specific mRNAs encoding two major TRP63 isoforms, a transactivating transcription factor and a dominant n...

journal_title：Endocrine-related cancer

authors： Assefnia S,Kang K,Groeneveld S,Yamaji D,Dabydeen S,Alamri A,Liu X,Hennighausen L,Furth PA

更新日期：2014-05-06 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-Pa...

journal_title：Endocrine-related cancer

authors： Krauss T,Ferrara AM,Links TP,Wellner U,Bancos I,Kvachenyuk A,Villar Gómez de Las Heras K,Yukina MY,Petrov R,Bullivant G,von Duecker L,Jadhav S,Ploeckinger U,Welin S,Schalin-Jäntti C,Gimm O,Pfeifer M,Ngeow J,Hasse-Laza

更新日期：2018-09-01 00:00:00

abstract：:Many clinicians prefer to avoid surgery in patients with carcinoid neoplasia, because of its slow growth and relatively favourable prognosis. Nevertheless, the commonest cause of death in patients with carcinoid is advanced metastatic disease, and both clinical and epidemiological data indicate that the more effective...

journal_title：Endocrine-related cancer

authors： Sutton R,Doran HE,Williams EM,Vora J,Vinjamuri S,Evans J,Campbell F,Raraty MG,Ghaneh P,Hartley M,Poston GJ,Neoptolemos JP

更新日期：2003-12-01 00:00:00

abstract：:Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can occur sporadically or as a part of different hereditary tumor syndromes. About 30% of PCCs and PGLs are currently believed to be caused by germline mutat...

journal_title：Endocrine-related cancer

authors： Welander J,Söderkvist P,Gimm O

更新日期：2011-12-01 00:00:00

abstract：:The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is widely known to be involved in tumour progression. Recently, we have described the upregulation of MCT1 in breast carcinomas and its a...

journal_title：Endocrine-related cancer

authors： Morais-Santos F,Miranda-Gonçalves V,Pinheiro S,Vieira AF,Paredes J,Schmitt FC,Baltazar F,Pinheiro C

更新日期：2013-12-16 00:00:00

abstract：:The androgen receptor (AR) mediates the effects of male steroid hormones (androgens) and contributes to a wide variety of physiological and pathophysiological conditions. As such, the regulatory mechanisms governing AR activity are of high significance. Concerted effort has been placed on delineating the mechanisms th...

journal_title：Endocrine-related cancer

authors： Burd CJ,Morey LM,Knudsen KE

更新日期：2006-12-01 00:00:00

abstract：:The thyroid hormones T3 and T4 have emerged as pro-angiogenic hormones with important implications for cancer management. Endogenous circulating hormone levels may help stimulate cancer progression and limit the effectiveness of anticancer therapy, though clinical data remain inconclusive. The capacity of thyroid horm...

journal_title：Endocrine-related cancer

authors： Schmohl KA,Nelson PJ,Spitzweg C

更新日期：2019-06-01 00:00:00

abstract：:Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with in...

journal_title：Endocrine-related cancer

authors： Crujeiras AB,Diaz-Lagares A,Stefansson OA,Macias-Gonzalez M,Sandoval J,Cueva J,Lopez-Lopez R,Moran S,Jonasson JG,Tryggvadottir L,Olafsdottir E,Tinahones FJ,Carreira MC,Casanueva FF,Esteller M

更新日期：2017-07-01 00:00:00

abstract：:Combined clinical and laboratory investigations of multiple endocrine neoplasia type 1 (MEN1) have resulted in an increased understanding of this disorder which may be inherited as an autosomal dominant condition. Defining the features of each disease manifestation in MEN1 has improved patient management and treatment...

journal_title：Endocrine-related cancer

authors： Pannett AA,Thakker RV

更新日期：1999-12-01 00:00:00

abstract：:It has been proposed that knowledge of estrogen receptor beta (ER-beta) expression may refine estrogen receptor alpha (ER-alpha) predictivity of response to endocrine therapy. We challenged this hypothesis in ER-alpha-positive breast cancers subjected to preoperative antiestrogen treatment. Forty-seven elderly (> or =...

journal_title：Endocrine-related cancer

authors： Cappelletti V,Celio L,Bajetta E,Allevi A,Longarini R,Miodini P,Villa R,Fabbri A,Mariani L,Giovanazzi R,Galante E,Greco M,Grazia Daidone M

更新日期：2004-12-01 00:00:00

abstract：:Long-term culture of MCF-7 wild-type (wt) cells in steroid-depleted medium (LTED) results in hypersensitivity to oestradiol (E2) coinciding with elevated levels of ERalpha and enhanced growth factor signalling. In this study, we aimed to compare the effects of the pure anti-oestrogen ICI 182,780 (ICI) with the competi...

journal_title：Endocrine-related cancer

authors： Martin LA,Pancholi S,Chan CM,Farmer I,Kimberley C,Dowsett M,Johnston SR

更新日期：2005-12-01 00:00:00

abstract：:The anaplastic lymphoma kinase (ALK) gene is frequently rearranged in various types of cancer and is highly responsive to targeted therapeutics. We developed a system to detect rearrangement of ALK in a large group of Korean thyroid cancer patients. We screened 474 malignant or benign thyroid tumor cases to identify A...

journal_title：Endocrine-related cancer

authors： Park G,Kim TH,Lee HO,Lim JA,Won JK,Min HS,Lee KE,Park DJ,Park YJ,Park WY

更新日期：2015-02-01 00:00:00