A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats.


OBJECTIVES:This study compared the acute treatment effects of systemic analgesics with (celecoxib) and without anti-inflammatory activity (acetaminophen) on bone fracture healing. STUDY DESIGN:Longitudinal time study of fracture healing in rats. METHODS:Closed, mid diaphyseal femur fractures were produced in female Sprague-Dawley rats. The rats were treated for 10 days after fracture with 60 or 300 mg/kg of acetaminophen, 3 or 6 mg/kg of celecoxib, or vehicle by once-daily oral dosing. Fracture healing was measured after 8 weeks by radiographic examination, mechanical testing, and histology. RESULTS:Radiographic scoring indicated that acute celecoxib treatment significantly impaired fracture healing; acetaminophen treatment had no negative effect. Mechanical testing supported the radiographic observations. No negative effects of celecoxib or acetaminophen treatment on the structural properties (peak torque and torsional rigidity) of the healing femurs were detected. In contrast, celecoxib treatment, but not acetaminophen treatment, significantly reduced the material properties (maximum shear stress and shear modulus) of the healing femurs (P < 0.001). Post-mechanical testing examination of the healing femurs found that 73% of the vehicle-treated or acetaminophen-treated femurs had healed as unions (30/41), 27% failed as incomplete unions (11/41), and none failed as nonunions (0%). In contrast, only 21% of the fractured femurs from the celecoxib treated rats had healed as unions (7/34), 53% failed as incomplete unions (18/34), and 26% failed as nonunions (9/34). The proportion of nonunions among the celecoxib-treated rats was significantly higher compared with the control and acetaminophen-treated rats (P < 0.001). Histologic examination indicated that similar to previous studies, celecoxib treatment, but not acetaminophen treatment, altered normal fracture callus morphology in which cartilage rather than new bone abuts the fracture site. CONCLUSIONS:No negative effect from acute acetaminophen treatment on fracture healing was detected. In contrast, acute treatment with celecoxib, a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity, significantly impaired fracture healing.


J Orthop Trauma


Bergenstock M,Min W,Simon AM,Sabatino C,O'Connor JP




Has Abstract


2005-11-01 00:00:00














  • Femoral nerve palsy after pelvic fracture treated with INFIX: a case series.

    abstract:OBJECTIVE:The treatment of some pelvic injuries has evolved recently to include the use of a subcutaneous anterior pelvic fixator (INFIX). We present 8 cases of femoral nerve palsy in 6 patients after application of an INFIX to highlight this potentially devastating complication to pelvic surgeons using this technique ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Hesse D,Kandmir U,Solberg B,Stroh A,Osgood G,Sems SA,Collinge CA

    更新日期:2015-03-01 00:00:00

  • Connective tissue parameters in experimental nonunion.

    abstract::A previously developed experimental model for producing nonunions in rats was used to study the biochemical changes of connective tissue parameters in impaired fracture repair. The model is based on rotational instability between the fracture fragments. A mid-diaphyseal femoral osteotomy was performed on 30 male rats ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Hietaniemi K,Paavolainen P,Penttinen R

    更新日期:1996-01-01 00:00:00

  • A cost analysis of internal fixation versus nonoperative treatment in adult midshaft clavicle fractures using multiple randomized controlled trials.

    abstract:BACKGROUND:To determine whether the cost of nonoperative treatment, including those who require delayed operative treatment, is less than those receiving initial operative management. METHODS:We identified 4 recent randomized controlled trials comparing operative and nonoperative treatment of displaced midshaft clavic...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,meta分析,评审


    authors: Walton B,Meijer K,Melancon K,Hartman M

    更新日期:2015-04-01 00:00:00

  • Donor Site Morbidity After Anterior Iliac Bone Graft Harvesting.

    abstract:OBJECTIVES:The objective of this study was to evaluate donor site morbidity associated with anterior iliac crest bone graft harvesting for orthopaedic trauma reconstructions. DESIGN:Retrospective case series. SETTING:Level 1 trauma center. PATIENTS:Forty-Six consecutive patients who had undergone anterior iliac cres...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Shin SR,Tornetta P 3rd

    更新日期:2016-06-01 00:00:00

  • A staged protocol for soft tissue management in the treatment of complex pilon fractures.

    abstract:OBJECTIVE:To determine whether open reduction and internal fixation of intra-articular pilon fractures using a staged treatment protocol results in minimal surgical wound complications. DESIGN:Retrospective. SETTING:Level 1 trauma center. PATIENTS/PARTICIPANTS:Between January 1991 and December 1996, 226 pilon fractu...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Sirkin M,Sanders R,DiPasquale T,Herscovici D Jr

    更新日期:1999-02-01 00:00:00

  • Symmetry Matching of the Medial Acetabular Surface-A Quantitative Analysis in View of Patient-Specific Implants.

    abstract:OBJECTIVE:To quantify intrapelvic surface symmetry in reference to a preshaped suprapectineal acetabular implant. METHODS:In this cross-sectional study, an anatomically preshaped acetabular fracture implant was fitted on 3D surface models of 516 pelvises from a preexisting bone database using a software tool for autom...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Osterhoff G,Petersik A,Sprengel K,Pape HC

    更新日期:2019-03-01 00:00:00

  • A Review of Atypical Femoral Fractures From a Tertiary Care Teaching Hospital: An Alarming Trend?

    abstract:OBJECTIVE:To evaluate the experience of a single tertiary care teaching hospital with the association between use of bisphosphonates and atypical femoral fractures, and to identify potential risk factors and chronologic incidence. DESIGN:Retrospective review. SETTING:Tertiary-care teaching hospital. PATIENTS:Thirty-...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Black JD,Kancherla VK,De Long WG Jr

    更新日期:2016-04-01 00:00:00

  • Radiographic fracture assessments: which ones can we reliably make?

    abstract:OBJECTIVE:To identify the fracture characteristics that can be reliably assessed by analysis of plain radiographs of tibial plateau fractures. DESIGN:Radiographic review study. PARTICIPANTS:Five orthopaedic traumatologists served as observers. INTERVENTION:Observers made assessments based on the radiographs of fifty...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Martin J,Marsh JL,Nepola JV,Dirschl DR,Hurwitz S,DeCoster TA

    更新日期:2000-08-01 00:00:00

  • Knee arthrodesis with simultaneous lengthening using the Ilizarov method.

    abstract:OBJECTIVE:To determine whether knee arthrodesis with simultaneous lengthening using the Ilizarov method for a nonreconstructable knee joint with bone loss and infection is a successful salvage procedure. DESIGN:Retrospective review of patients. SETTING:University hospital-based orthopaedic practice. PATIENTS:From 19...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Rozbruch SR,Ilizarov S,Blyakher A

    更新日期:2005-03-01 00:00:00

  • Reconstructive amputation after grade IIIC open tibial fracture. One method of preserving residual limb length.

    abstract::A high percentage of patients with grade IIIC open tibial fractures eventually undergo amputation. Maintaining an adequate residual limb length is advantageous with regard to biomechanics, energy expenditure, and prosthetic fitting. This case report presents new considerations for maintaining residual limb length in t...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Hartford JM,Abdu WA,Mayor MB

    更新日期:1994-08-01 00:00:00

  • Unexpected high complication rate following internal fixation of unstable proximal humerus fractures with an angled blade plate.

    abstract:OBJECTIVES:The increasing number of fractures of the proximal humerus, especially in the elderly, carries with it the unsolved problem of the optimal treatment for the displaced or unstable fractures. The authors' goal was to analyze whether fixation with a bent valgus angled blade plate could improve the outcomes repo...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Meier RA,Messmer P,Regazzoni P,Rothfischer W,Gross T

    更新日期:2006-04-01 00:00:00

  • Deep venous thrombosis complicating rupture of the medial head of the gastrocnemius muscle.

    abstract::Rupture of the medial head of the gastrocnemius muscle ("tennis leg") is an affliction generally associated with athletic activity. The diagnosis is made by careful history and physical examination. Although its findings are characteristic, previous reports have documented misdiagnosis of this lesion as thrombophlebit...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Slawski DP

    更新日期:1994-01-01 00:00:00

  • The Community Orthopaedic Surgeon Taking Trauma Call: Pediatric Femoral Shaft Fracture Pearls and Pitfalls.

    abstract::Pediatric femoral shaft fractures present many challenging patient care decisions. Nonoperative treatment approaches still dominate care of the youngest age groups while surgical intervention is commonplace in virtually all older children. Treatment is determined primarily by patient age as modified by clinical factor...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Gordon JE,Mehlman CT

    更新日期:2017-11-01 00:00:00

  • Modern perspectives of open reduction and plate fixation of proximal humerus fractures.

    abstract::Recent innovations have greatly increased the range of proximal humeral fractures that are amenable to open reduction and plate fixation.The optimum technique for some of the more complex fracture patterns is not yet fully refined.This article aims to describe the recent advances in the treatment of complex proximal h...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Robinson CM,Amin AK,Godley KC,Murray IR,White TO

    更新日期:2011-10-01 00:00:00

  • The long-term results of nonoperatively treated major pelvic disruptions.

    abstract::Twenty-six patients with major anterior-posterior pelvic disruptions not involving the acetabulum were reevaluated an average of 8 years (minimum 5 years) after injury. All pelvic injuries were treated nonoperatively. Subjective complaints at the time of follow-up included frequent or daily low back discomfort (50%), ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Henderson RC

    更新日期:1989-01-01 00:00:00

  • An investigation of the contribution of the extraosseous tissues to the diaphyseal fracture callus using a rabbit tibial fracture model and in situ immunocytochemical localisation of osteocalcin.

    abstract::The extraosseous tissue contribution to diaphyseal fracture callus has been investigated using a rabbit tibial fracture model and osteocalcin immunocytochemistry. The extraosseous tissues were isolated for study by reaming and nailing an osteotomy and excising 2 cm of periosteum on either side of the osteotomy. Specim...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Stafford H,Oni OO,Hay J,Gregg PJ

    更新日期:1992-01-01 00:00:00

  • Plate fixation of femoral nonunions over an intramedullary nail with autogenous bone grafting.

    abstract:OBJECTIVE:To describe a novel approach for the treatment of nonunions of diaphyseal femur fractures. DESIGN:Retrospective review. SETTING:University hospital. PATIENTS:Seven patients (six men, one woman, average age 42.5 years) with diaphyseal femoral fracture nonunions treated between November 2006 and November 200...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Hakeos WM,Richards JE,Obremskey WT

    更新日期:2011-02-01 00:00:00

  • Concomitant ipsilateral intertrochanteric and subcapital fracture of the hip.

    abstract::A unique case of coexistent intertrochanteric and subcapital fractures of the hip is presented. A review of the literature found only one previous report of the simultaneous occurrence of these fractures. Closed reduction with in situ pinning was performed. Other treatment alternatives are reviewed and discussed. ...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Isaacs C,Lawrence B

    更新日期:1993-01-01 00:00:00

  • A concept for the validation of fracture classifications.

    abstract::The fracture classification systems currently used most frequently were not developed or validated by rigorous scientific evaluation methods. This paper discusses the classification of fractures from an epidemiological and clinical decision-making perspective and proposes a standardized methodological concept for thei...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章,评审


    authors: Audigé L,Bhandari M,Hanson B,Kellam J

    更新日期:2005-07-01 00:00:00

  • A biomechanical study of three wiring techniques for cerclage-plating.

    abstract::Transverse fractures at the distal tip of a well-fixed femoral prosthesis are difficult to stabilize using plates and screws due to the presence of the underlying intramedullary stem. The attachment of plates using cerclage wires obviates the need for screws, but the stability provided by cerclage plating is a clinica...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Stevens SS,Irish AJ,Vachtsevanos JG,Csongradi J,Beaupré GS

    更新日期:1995-01-01 00:00:00

  • Overlapping Surgery for Ankle Fractures: Is It Safe?

    abstract:OBJECTIVE:To determine whether the practice of overlapping surgery influenced patient safety after open reduction internal fixation (ORIF) for ankle fractures. DESIGN:Retrospective case-control. SETTING:Level 1 Academic Midwest trauma center. PATIENTS:All patients who underwent ankle fracture ORIF by a single surgeo...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Baessler A,Mullis B,Loder R,Corn K,Mavros C

    更新日期:2020-08-01 00:00:00

  • Quality of Reduction of Displaced Intra-Articular Calcaneal Fractures Using a Sinus Tarsi versus Extensile Lateral Approach.

    abstract:OBJECTIVE:To evaluate the difference in quality of fracture reduction between the sinus tarsi approach (STA) and extensile lateral approach (ELA) using postoperative CT scans in displaced intra-articular calcaneal fractures (DIACFs). DESIGN:Retrospective SETTING:: Level 1 and Level 2 academic centers. PATIENTS:Consec...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Busel G,Mir HR,Merimee S,Patel R,Atassi O,De La Fuente G,Donohue D,Maxson B,Infante A,Shah A,Watson D,Downes K,Sanders RW

    更新日期:2020-09-18 00:00:00

  • Displaced Radial Shaft Fracture: The Dorsal (Thompson) Approach to the Forearm.

    abstract::This video demonstrates a displaced radial shaft fracture repaired through a dorsal (Thompson) approach to the forearm. The patient is an 18-year-old man who sustained a left elbow dislocation and ipsilateral radial shaft fracture (OTA/AO: 22-B2) while playing basketball. The patient underwent a closed reduction of th...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Shields CN,Egol KA

    更新日期:2020-08-01 00:00:00

  • Effect of stainless steel and titanium low-contact dynamic compression plate application on the vascularity and mechanical properties of cortical bone after fracture.

    abstract:OBJECTIVES:Comparison of the effect of stainless steel and titanium low-contact dynamic compression plate application on the vascularity and mechanical properties of cortical bone after fracture. DESIGN:Randomized, prospective. SETTING:Orthopaedic research laboratory. ANIMALS:Ten large (greater than twenty-five kilo...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Jain R,Podworny N,Hearn T,Anderson GI,Schemitsch EH

    更新日期:1997-10-01 00:00:00

  • Unstable proximal extraarticular tibia fractures: a biomechanical evaluation of four methods of fixation.

    abstract:OBJECTIVE:To compare the biomechanical stability of extraarticular proximal tibia fractures reconstructed using a double-plate construct, locking plate system, hybrid external fixator, and single lateral periarticular plate, all from the same manufacturer. DESIGN:Standardized proximal tibial fractures (AO classificati...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Peindl RD,Zura RD,Vincent A,Coley ER,Bosse MJ,Sims SH

    更新日期:2004-09-01 00:00:00

  • Hip fractures: an increasing health care cost.

    abstract::Studies in several countries have indicated that there is likely to be a dramatic increase in the number of hip fractures in the early part of the 21st century. At a time when health care costs are coming under close scrutiny internationally, the added financial burden of the increasing number of fractures is of conce...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Cox MA,Bowie R,Horne G

    更新日期:1993-01-01 00:00:00

  • Angular malalignment after intramedullary nailing of femoral shaft fractures.

    abstract:OBJECTIVES:To determine factors associated with angular malalignment of femoral shaft fractures treated with intramedullary nails and to determine differences in the incidence of angular malalignment based on fracture location, fracture comminution, and method of treatment (i.e., antegrade or retrograde). DESIGN:Retro...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Ricci WM,Bellabarba C,Lewis R,Evanoff B,Herscovici D,Dipasquale T,Sanders R

    更新日期:2001-02-01 00:00:00

  • Bone and cartilage formation in an experimental model of distraction osteogenesis.

    abstract:OBJECTIVES:(a) To develop a reliable and reproducible system for distraction osteogenesis in the rat to establish a model for future investigations of bone repair and regeneration. (b) To describe and characterize the histological events in distraction osteogenesis in the rat and to determine whether cartilage developm...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Jazrawi LM,Majeska RJ,Klein ML,Kagel E,Stromberg L,Einhorn TA

    更新日期:1998-02-01 00:00:00

  • A mechanical comparison of the locking compression plate (LCP) and the low contact-dynamic compression plate (DCP) in an osteoporotic bone model.

    abstract:OBJECTIVE:To determine if locking compression plates (LCP) are mechanically advantageous compared to low-contact dynamic compression plates (DCP) when used as a bridging plate in a synthetic model of osteoporotic bone. METHODS:Five synthetic bars (Synbone Osteoporotic bone) were initially tested in compression and the...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Snow M,Thompson G,Turner PG

    更新日期:2008-02-01 00:00:00

  • 9. Effects of Low-Intensity Pulsed Ultrasound (LIPUS) on Osteoclasts and Osteoblasts: Analysis Using an Assay System With Fish Scale as a Model of Bone.

    abstract:OBJECTIVE:Low-intensity pulsed ultrasound (LIPUS) provides noninvasive therapeutic treatment to accelerate fracture repair and distraction osteogenesis. However, most studies concerning the influence of LIPUS on bone metabolism have been conducted in vivo systems using osteoblastic cells. Therefore, details of the dire...

    journal_title:Journal of orthopaedic trauma

    pub_type: 杂志文章


    authors: Suzuki N,Hanmoto T,Ikegame M,Furusawa Y,Tabuchi Y,Kondo T,Kitamura K,Sekiguchi T,Mikuni-Takagaki Y,Hattori A

    更新日期:2016-08-01 00:00:00