The role of electrical stimulation in bone repair.

Abstract:

:Electric and electromagnetic fields regulate extra-cellular matrix synthesis and stimulate repair of fractures and nonunions. Studies of electric and electromagnetic fields suggest they (1) regulate proteoglycan and collagen synthesis and increase bone formation in models of endochondral ossification, (2) accelerate bone formation and repair, (3) increase union rates in fractures previously refractory to healing, and (4) produce results equivalent to bone grafts. Electric and electromagnetic fields regulate the expression of genes in connective tissue cells for extra-cellular matrix proteins, which results in an increase in cartilage and bone. They also increase gene expression for and synthesis of growth factors, which may be an intermediary mechanism of activity and may amplify field effects through autocrine and paracrine signaling.

journal_name

Foot Ankle Clin

journal_title

Foot and ankle clinics

authors

Ciombor DM,Aaron RK

doi

10.1016/j.fcl.2005.06.006

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

579-93, vii

issue

4

eissn

1083-7515

issn

1558-1934

pii

S1083-7515(05)00077-X

journal_volume

10

pub_type

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