Abstract:
:Parkinson's disease is a prevalent progressive degenerative disorder of the elderly. There is a current need for novel therapeutic strategies because the standard levodopa pharmacotherapy is only temporarily efficacious. Recently, there have been some high-profile successful preclinical results obtained in animal models of neurological disorders using small interfering RNAs delivered by viral vectors. RNA interference can theoretically be applied to Parkinson's disease since over-expression of various proteins is known to kill the dopamine neurons of the substantia nigra in animal models and in familial forms of Parkinson's disease. Potential RNA interfering strategies and caveats are discussed in this review.
journal_name
Gene Therjournal_title
Gene therapyauthors
Manfredsson FP,Lewin AS,Mandel RJdoi
10.1038/sj.gt.3302669subject
Has Abstractpub_date
2006-03-01 00:00:00pages
517-24issue
6eissn
0969-7128issn
1476-5462pii
3302669journal_volume
13pub_type
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