Abstract:
:Cyclosporin is a potent immunosuppressant drug commonly used to prevent organ transplant rejection. In recent years, there has been a widening of its therapeutic use and an increase in the number of patients undergoing transplantation. Gingival overgrowth is one of several oral side-effects of cyclosporin, with a quoted prevalence of between 8% and 100%. There is continued debate over the factors which modify the degree of overgrowth, including individual sensitivity, age, dose of drug, duration of drug therapy and the presence of dental plaque. The exact mechanism of gingival overgrowth is still being debated, but appears to be caused by a combination of the proliferation of fibroblasts within the gingival tissue, an increase in the deposition of collagen and extracellular matrix, and a decrease in phagocytosis with a net gain in gingival tissue mass. A number of treatment options are utilized in the treatment of gingival overgrowth, including CO2 laser surgery, improved oral hygiene, the use of antibiotics such as metronidazole and azithromycin, and surgical intervention. In the clinical application of cyclosporin, there is little correlation between cyclosporin dose, serum trough levels and total exposure to the drug, making it difficult to achieve the desired therapeutic response. These problems were previously further complicated by the variability of absorption of the drug via the gastrointestinal tract. The original cyclosporin formulation, Sandimmune, was replaced by a new formulation, Neoral, which has a more reliable absorption, and gives a closer correlation between trough concentration levels and individual bioavailability. There is a conflict of opinion over whether or not the side-effect profile of Neoral varies from its precursor Sandimmune. It has yet to be seen whether the increased bioavailability of Neoral will result in an increased severity and prevalence of gingival overgrowth. An alternative immunosuppressant drug, tacrolimus, which is a macrolide antibiotic with a different side-effect profile, has emerged as a substitute for cyclosporin in organ transplantation. However, there have been conflicting reports of its side-effects and its capacity to cause gingival overgrowth.
journal_name
Int J Paediatr Dentjournal_title
International journal of paediatric dentistryauthors
Wright G,Welbury RR,Hosey MTdoi
10.1111/j.1365-263X.2005.00676.xsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
403-11issue
6eissn
0960-7439issn
1365-263Xpii
IPD676journal_volume
15pub_type
杂志文章,评审abstract:BACKGROUND:The dental literature is replete with reports on the oral health surveys of normal children. Relatively few data exist for the oral conditions of mentally challenged children and adolescents with multiple disabilities in India. AIM:To assess the oral hygiene practices and treatment needs among 6-12-year-old...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12088
更新日期:2014-11-01 00:00:00
abstract::Balancing the extraction of primary teeth is a procedure advocated to maintain symmetry of the developing dentition by encouraging symmetrical drift of teeth mesial and distal to the extraction sites on each side of the dental arch. Current opinion about this procedure expressed in standard reference works is confused...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章,评审
doi:10.1111/j.1365-263x.1993.tb00081.x
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Oral health perception has multidimensional nature and can be influenced not only by clinical conditions but also by psychosocial characteristics. HYPOTHESIS:Dental fear could modify the association between dental caries and dental pain and the perception of negative impact. DESIGN:A cross-sectional study ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12359
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Diet cariogenicity plays a major role as both a protective and risk factor in the development of early childhood caries (ECC). AIM:Develop a scale measuring the cariogenicity of foods and beverages and employ it to describe the cariogenicity of young children's diets and predict dental caries outcomes. DES...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12470
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:This paper describes the case of a 7-day-old girl who was referred to a paediatric dentistry clinic because of the presence of a pedunculated mass protruding from the front of her mouth. CASE REPORT:The mass was attached to the maxillary alveolus to the right of the midline, and was clinically diagnosed as ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2006.00795.x
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:The position of children in society has changed with increasing emphasis on children's rights and child-centred services. This study aimed to describe the extent to which contemporary oral health research has been conducted with or on children. DESIGN:A systematic review of the child dental literature from ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章,评审
doi:10.1111/j.1365-263X.2007.00845.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Usher syndrome is a genetic disorder consisting of progressive loss of vision and hearing. CASE REPORT:The paper describes an 8-year-old girl with Usher syndrome type I who presented with generalized defects of the permanent dentition and ectopic eruption of the right maxillary first permanent molar. A coch...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2006.00778.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The paediatric dentist must be familiar with a range of medical problems which can affect the mouth or general health of children. Dental clinicians are ideally placed to help with the detection of a range of gastrointestinal issues and should know when to refer to the paediatric specialist for advice. METH...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章,评审
doi:10.1111/ipd.12056
更新日期:2013-09-01 00:00:00
abstract:AIMS:This study aimed to assess changes in caries prevalence and severity in preschool children in Diadema, Brazil. METHODS:Three cross-sectional surveys were conducted, using the same protocol, in 1995, 1997 and 1999. The first survey included children aged 5-35 months, and the second and third, children aged 5-59 mo...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.2002.00352.x
更新日期:2002-05-01 00:00:00
abstract::This study was designed to examine reported infant feeding, oral hygiene, and dental attendance practices in children who had established dental disease before attaining school age. Data were collected by structured interview from the mothers of 150 children aged 5 years and under who were referred to a hospital Paedi...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.1997.00049.x
更新日期:1997-12-01 00:00:00
abstract::A study was carried out to compare the effectiveness of two doses of temazepam elixir for the behaviour management of paediatric dental patients. Twenty-two children aged 2-5 years (mean 4.06 years), classified as ASA Class I and II (American Society of Anesthesiologists Classification), were assigned to receive eithe...
journal_title:International journal of paediatric dentistry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-263x.1995.tb00171.x
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Parents play an important role in their children's oral health behaviors, provide oral health access, initiate prevention, and coping strategies for health care. AIM:This paper develops a short form (SF) to assist parents to evaluate their children's oral health status using Patient-Reported Outcome Measure...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12453
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Hydrophilic adhesives may be used as pit and fissure sealants (sealants), but there is concern about the ability of self-etching adhesives to bond sealants to enamel. AIM:To study the bond strength (BS) and morphology of adhesive systems used as sealants. DESIGN:OptiBond FL, OptiBond All-in-One, combined O...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2011.01213.x
更新日期:2012-11-01 00:00:00
abstract::Dental fear is a widespread problem that represents one of the major barriers to dental care. This report describes a case study of a 12-year-old boy who presented with dental phobia characterized as 'fear of catastrophe', 'generalized dental fear' and 'fear of specific stimuli'. The referral came from his general den...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.2000.00218.x
更新日期:2000-12-01 00:00:00
abstract::The clinical success and effect upon the age at which teeth exfoliated was prospectively observed in 175 primary molars that had received formoceresol pulpotomies performed by one operator. The success rate among 142 vital teeth was 99.3% and among 33 non-vital teeth 84.8%. There was no significant effect upon age at ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263x.1996.tb00222.x
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Caries risk assessment is an important tool in clinical decision making. AIM:To evaluate longitudinal changes in caries risk profiles in a group of schoolchildren in relation to caries development. DESIGN:The Cariogram model was used to create caries risk profiles and to identify risk factors in 438 childr...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2010.01064.x
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Several factors can influence the oral health. AIM:To explore the clinical factors, individual characteristics, and environmental factors (religious-spiritual coping-RSC, sense of coherence [SOC], and socio-economic status) related to oral status and impact on oral health-related quality of life (OHRQoL) of...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12594
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:(i) To compare the prevalence and levels of Capnocytophaga, a known systemic pathogen in immunocompromised patients, in the dental plaque of healthy children and children with cancer, and (ii) to determine the susceptibility of strains isolated from cancer patients to a range of antibiotics. PATIENTS AND ME...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2006.00697.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to provide data on the prevalence of clinical signs of traumatic injuries to the chin and of parental report of such injuries in a group of children visiting a private paediatric dental practice. SAMPLE AND METHODS:The study group comprised 303 children (151 boys and 152 girls) whose...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.1998.00071.x
更新日期:1998-06-01 00:00:00
abstract:INTRODUCTION:Children who present with a posterior cross-bite in the primary dentition may be predisposed to long-term detrimental consequences if the condition is left untreated. Controversy exists in the literature as to the most appropriate time to treat this condition. OBJECTIVES:The aim of this review is to evalu...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章,评审
doi:10.1111/j.1365-263X.2004.00546.x
更新日期:2004-05-01 00:00:00
abstract::The traditional caries index, DMF, provides inadequate information to assess dental treatment needs of a community. Dental health planners are often called upon to estimate the treatment needs, costs, time and personnel required for a proposed programme. A treatment needs index (TNI) is presented which provides import...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263x.1993.tb00068.x
更新日期:1993-09-01 00:00:00
abstract:AIM:The aim of this study was to show the morphology of the carious lesion in dentine in three dimensions (3D). DESIGN:A novel high-definition X-ray microtomography (XMT) scanner was used to scan 10 carious primary molars at a resolution of 15 x 15 x 15 microm3. A stack of approximately 640 XMT slices were recorded fo...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263X.2006.00766.x
更新日期:2006-11-01 00:00:00
abstract::Two case reports are presented, both clearly demonstrating the diagnosis of oral-facial-digital syndrome, type I, but widely different in the expression of the condition. The first patient showed only mild expression of the syndrome. On examination at the age of 4 years there were no obvious extra oral signs, intraora...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263x.2004.00503.x
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Salt fluoridation is considered a cost-effective community strategy for reducing caries. AIM:To evaluate the effect of school-based and domestic distribution of F-salt to schoolchildren residing in a disadvantaged community. DESIGN:Seven hundred and thirty-three schoolchildren (12-14 years), attending two ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/ipd.12045
更新日期:2014-05-01 00:00:00
abstract::A boy developed Stevens-Johnson syndrome (erythema multiforme) 2 weeks after taking a course of slow-release theophylline at the age of 9 years. He had suffered from bronchial asthma since early infancy. He did not attend for dental treatment until the age of 14 years, when panoramic radiography demonstrated varying d...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263x.1994.tb00112.x
更新日期:1994-06-01 00:00:00
abstract::Patients with short familial stature (SFS) have a short body height, but their bone age is normal. The aim of this research was to assess dental maturity in 54 patients with SFS, aged from 4 to 15 1/2 years. Bone age was judged from radiographs of the left wrist, and dental age from orthopantomograms. Dental age was r...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1111/j.1365-263x.1997.tb00267.x
更新日期:1997-03-01 00:00:00
abstract::Maintaining a high standard of dental health in children with special needs, particularly those who are unable to control mandibular activity, can prove difficult and time consuming for parents, carers and dental professionals. This article describes the construction of an individually made and relatively unobtrusive ...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.2000.00161.x
更新日期:2000-03-01 00:00:00
abstract:AIM:To assess the undergraduate students' performance in detecting and staging caries and assessing activity using visual inspection. DESIGN:Two independent reviewers searched the literature through PubMed/MEDLINE, Scopus, Lilacs databases, and OpenSINGLE. Meta-analyses summarized the results concerning reproducibilit...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章,meta分析
doi:10.1111/ipd.12463
更新日期:2019-05-01 00:00:00
abstract::This case report describes the dental and physical anomalies observed in a young female patient who had a chromosome abnormality involving deletion of the q 33-q 35 region of chromosome 2. The dental dysplasia observed in this patient is proposed to be of genetic origin but the complication of anoxia at birth makes it...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Both primary upper second molars were extracted from a young male patient. The left had a normal root pattern but the right had four well-defined roots. The accessory root appeared to be the mesiopalatal which had a distinctly rounded cross-sectional profile. The other roots had the typical form characteristic of prim...
journal_title:International journal of paediatric dentistry
pub_type: 杂志文章
doi:10.1046/j.1365-263x.1998.00093.x
更新日期:1998-12-01 00:00:00