Propofol: the challenges of formulation.

abstract：:Medical records of 38 patients undergoing anesthesia and surgery for removal of an insulinoma were reviewed to determine 1) the safety of avoiding intraoperative glucose, 2) the appropriate frequency of plasma glucose analysis, and 3) the accuracy of using rebound hyperglycemia as an indication of tumor removal. Plasm...

journal_title：Anesthesiology

authors： Muir JJ,Endres SM,Offord K,van Heerden JA,Tinker JH

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:The distribution and elimination of 0.9% saline given by intravenous infusion has not been compared between the conscious state and during inhalational anesthesia. METHODS:Six adult sheep received an intravenous infusion of 25 ml/kg of 0.9% saline over 20 min in the conscious state and also during isofluran...

journal_title：Anesthesiology

authors： Brauer KI,Svensén C,Hahn RG,Traber LD,Prough DS

更新日期：2002-02-01 00:00:00

abstract：:Whereas opiate receptor agonists have resulted in spinal cord damage; opiate receptor antagonists have demonstrated protection against spinal cord injury. Because opioids are used in clinical anesthesia, the effect of an opiate antagonist was evaluated on neurologic outcome in a rat model of spinal cord injury occurri...

journal_title：Anesthesiology

authors： Cole DJ,Drummond JC,Shapiro HM,Hertzog RE,Brauer FS

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Isoflurane-anesthetized rats have better outcome from global cerebral ischemia than rats anesthetized with fentanyl and nitrous oxide. The authors wanted to determine whether circulating catecholamine concentrations depend on the anesthetic agent and whether sympathetic ganglionic blockade affects anesthetic...

journal_title：Anesthesiology

authors： Mackensen GB,Nellgård B,Miura Y,Chu CT,Dexter F,Pearlstein RD,Warner DS

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:The authors conducted a randomized, controlled, parallel-arm, superiority study to test the hypothesis that a continuous adductor canal block decreases the time to attain four discharge criteria compared with a continuous femoral nerve block after tricompartment knee arthroplasty. METHODS:Subjects undergoin...

journal_title：Anesthesiology

authors： Machi AT,Sztain JF,Kormylo NJ,Madison SJ,Abramson WB,Monahan AM,Khatibi B,Ball ST,Gonzales FB,Sessler DI,Mascha EJ,You J,Nakanote KA,Ilfeld BM

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Chronic pain models are commonly defined as either nerve-injury or inflammation models, but recent work suggests inflammatory processes are important in nerve injury-induced pain. METHODS:In the rat spinal nerve ligation model, the authors examined effects of systemic corticosteroid triamcinolone acetonide ...

journal_title：Anesthesiology

authors： Li H,Xie W,Strong JA,Zhang JM

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Sevoflurane is a volatile general anesthetic that differs in chemical nature from the gaseous anesthetic nitrous oxide. In a controlled laboratory setting, the authors characterized the subjective, psychomotor, and analgesic effects of sevoflurane and nitrous oxide at two equal minimum alveolar subanesthetic...

journal_title：Anesthesiology

authors： Galinkin JL,Janiszewski D,Young CJ,Klafta JM,Klock PA,Coalson DW,Apfelbaum JL,Zacny JP

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system. Although barbiturates have been shown to suppress the AMPA receptor-mediated responses, it is unclear whether this effect contributes to the a...

journal_title：Anesthesiology

authors： Kamiya Y,Andoh T,Furuya R,Hattori S,Watanabe I,Sasaki T,Ito H,Okumura F

更新日期：1999-06-01 00:00:00

abstract：:This study examined whether pain or stress can enhance the analgesic effects of spinally administered opiates. The experiments determined the effects of mechanically produced pain and of the stress of being restrained on the analgesic effects of 0.63 microgram of epidural sufentanil in rats using a tail-withdrawal pro...

journal_title：Anesthesiology

authors： Van den Hoogen RH,Bervoets K,Colpaert FC

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...

journal_title：Anesthesiology

authors： de Graaff JC,Pasma W,van Buuren S,Duijghuisen JJ,Nafiu OO,Kheterpal S,van Klei WA

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to predict changes in sedation and memory produced by various drugs was t...

journal_title：Anesthesiology

authors： Veselis RA,Reinsel RA,Feshchenko VA

更新日期：2001-10-01 00:00:00

abstract：:The effects of anesthetic drugs on lipid order were evaluated by the fluorescence polarization of the probe molecule, 1,6-diphenyl-1,3,5-hexatriene (DPH) incorporated into vesicles of dimyristoylphosphatidylcholine (DMPC) and DMPC with 10 mol% ganglioside (GD1a). Anesthetics (enflurane, chloroform, diethylether, pento...

journal_title：Anesthesiology

authors： Harris RA,Groh GI

更新日期：1985-02-01 00:00:00

abstract：:We recorded the frequency with which anesthesia personnel came in contact with patient body fluids in order to provide an empirical basis for the recommendation of relevant precautions. Anesthesia personnel completed a questionnaire when performing a range of standardized procedures. The rate of contact with blood was...

journal_title：Anesthesiology

authors： Kristensen MS,Sloth E,Jensen TK

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Cardiac complications are common during the postoperative period and may be associated with hypoxemia and tachycardia. Preliminary studies in high-risk patients after operation have shown a possible beneficial effect of oxygen therapy on arterial oxygen saturation and heart rate. METHODS:The authors studied...

journal_title：Anesthesiology

authors： Rosenberg-Adamsen S,Lie C,Bernhard A,Kehlet H,Rosenberg J

更新日期：1999-02-01 00:00:00

abstract：:Data regarding left ventricular function suggest that the extent of shortening may differ between regions. This study was undertaken to determine the effects of negative inotropic drugs used during anesthesia on different areas of the left ventricle. Forty mongrel dogs were anesthetized and instrumented for measuremen...

journal_title：Anesthesiology

authors： Diedericks J,Leone BJ,Foëx P

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:(human ether-a-gogo related gene) encodes the cardiac rapidly activating delayed rectifier potassium currents (I(kr)), which play an important role in cardiac action potential repolarization. General anesthetics, like halothane, can prolong Q-T interval, suggesting that they act on myocellular repolarization...

journal_title：Anesthesiology

authors： Li J,Correa AM

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:We evaluated whether spectral entropy (SpE) can measure the depth of hypnosis and the hypnotic drug effect in children during total intravenous anesthesia. METHODS:Sixty healthy children, aged 3-16 yr, were studied. Anesthesia was induced with an increasing target controlled infusion of propofol, and mainta...

journal_title：Anesthesiology

authors： Klockars JG,Hiller A,Münte S,van Gils MJ,Taivainen T

更新日期：2012-02-01 00:00:00

abstract：:To determine if continuous positive airway pressure (CPAP) or expiratory positive airway pressure (EPAP) is superior for achieving or maintaining effective lung volume in spontaneously breathing critically ill patients in acute respiratory failure, the authors measured functional residual capacity (FRC), airway and es...

journal_title：Anesthesiology

authors： Schlobohm RM,Falltrick RT,Quan SF,Katz JA

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:The value of exercise electrocardiography in the prediction of perioperative cardiac risk has yet to be defined. This study was performed to determine the predictive value of exercise electrocardiography as compared with clinical parameters and resting electrocardiography. METHODS:A total of 204 patients at...

journal_title：Anesthesiology

authors： Gauss A,Röhm HJ,Schäuffelen A,Vogel T,Mohl U,Straehle A,Meierhenrich R,Georgieff M,Steinbach G,Schütz W

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is a sedative with modest analgesic efficacy, whereas remifentanil is an opioid analgesic with modest sedative potency. Synergy is often observed when sedative-hypnotics are combined with opioid analgesics in anesthetic practice. A three-phase crossover trial was conducted to study the pharma...

journal_title：Anesthesiology

authors： Weerink MAS,Barends CRM,Muskiet ERR,Reyntjens KMEM,Knotnerus FH,Oostra M,van Bocxlaer JFP,Struys MMRF,Colin PJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant. In this randomized controlled trial, the authors sought to determine whether patients carrying the MTHFR C677T or A1298C variant...

journal_title：Anesthesiology

authors： Nagele P,Brown F,Francis A,Scott MG,Gage BF,Miller JP,VINO Study Team.

更新日期：2013-07-01 00:00:00

abstract：:Although it generally is agreed that halothane is a pulmonary vasodilator, its effect on venous admixture and hypoxic pulmonary vasoconstriction are more controversial. The effects of 2.4% halothane on pulmonary vascular resistance and venous admixture were investigated in an isolated canine lobe made atelectatic. Hal...

journal_title：Anesthesiology

authors： Johnson D,Hurst T,Mayers I

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Offset analgesia, in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation, has not been described previously in patients with chronic pain. METHODS:Offset analgesia responses in 10 patients with neuropathic pain (in both legs) were compared ...

journal_title：Anesthesiology

authors： Niesters M,Hoitsma E,Sarton E,Aarts L,Dahan A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:In animals, systemic and intrathecal administration of the alpha2 -adrenergic receptor agonist dexmedetomidine results in robust antinociceptive effects in models of heat pain. In humans, systemically administered dexmedetomidine is approved for sedating patients in the intensive care unit. However, whether ...

journal_title：Anesthesiology

authors： Angst MS,Ramaswamy B,Davies MF,Maze M

更新日期：2004-09-01 00:00:00

abstract：:Critically ill patients requiring mechanical ventilation are particularly susceptible to malnutrition. A knowledge of the energy requirements of these patients is essential in designing nutritional regimens. This study examines 45 resting energy-expenditure measurements performed in a group (n = 40) of postoperative, ...

journal_title：Anesthesiology

authors： Weissman C,Kemper M,Askanazi J,Hyman AI,Kinney JM

更新日期：1986-06-01 00:00:00

abstract：:The pattern of breathing and lung mechanics were evaluated during the first 7 h of life in full-term healthy newborns delivered by cesarean section with bupivacaine epidural anesthesia, without (group 1) or with the addition of 100 micrograms of fentanyl (group 2). Respiration and oxyhemoglobin saturation (SpO2) were ...

journal_title：Anesthesiology

authors： Benlabed M,Dreizzen E,Ecoffey C,Escourrou P,Migdal M,Gaultier C

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Due to economic pressures and improvements in perioperative care, outpatient surgical procedures have become commonplace. However, risk factors for outpatient surgical morbidity and mortality remain unclear. There are no multicenter clinical data guiding patient selection for outpatient surgery. The authors ...

journal_title：Anesthesiology

authors： Mathis MR,Naughton NN,Shanks AM,Freundlich RE,Pannucci CJ,Chu Y,Haus J,Morris M,Kheterpal S

更新日期：2013-12-01 00:00:00

abstract：:Eighty-three ASA Physical Status 1-2 patients were orally premedicated with triazolam (0.125, 0.25, or 0.5 mg), diazepam (5, 10, or 15 mg), or placebo to evaluate the effectiveness of these drugs and doses in reducing preoperative anxiety, providing sedation, and producing amnesia. The drug treatments were administere...

journal_title：Anesthesiology

authors： Baughman VL,Becker GL,Ryan CM,Glaser M,Abenstein JP

更新日期：1989-08-01 00:00:00

abstract：:The authors sought to determine if isoflurane would attenuate effects of three different types of vasoconstrictors on isolated segments of canine epicardial coronary arteries removed from healthy dogs. As the endothelium has a major role in regulating epicardial coronary artery tone, and as it modulates the effect of ...

journal_title：Anesthesiology

authors： Blaise G,Sill JC,Nugent M,Van Dyke RA,Vanhoutte PM

更新日期：1987-10-01 00:00:00

abstract：:Anesthesiologist-reviewers examined 1,175 anesthetic-related closed malpractice claims from 17 professional liability insurance companies. The claims were filed between 1974 and 1988. The reviewers were asked to determine if the negative outcome was preventable by proper use of additional monitoring devices available ...

journal_title：Anesthesiology

authors： Tinker JH,Dull DL,Caplan RA,Ward RJ,Cheney FW

更新日期：1989-10-01 00:00:00