Abstract：
:To study the aetiology of pressure ulcers an MR-compatible loading device was developed. Magnetic resonance imaging provides the possibility of non-invasive evaluation of muscle tissue after compressive loading. Pressure was applied to the tibialis anterior region of rats by means of an indenter. The developed MR-compatible loading device allowed high quality consecutive MR measurements for up to 6h. Tissue was evaluated both during and after loading. Two loading protocols were used; a large indentation of 4.5mm (mean pressure 150 kPa) was applied for 2h and a small indentation of 2.9 mm (mean pressure 50 kPa) was applied for 4h. T2-weighted MR images after the large indentation showed an immediate increase in signal intensity, associated with damage, following load removal. After 20 h the signal intensity remained higher in the affected regions. Afterwards the tissue was perfusion fixated for histological examination. Histological evaluation revealed an inflammatory response and severe muscle necrosis. No signal increase was observed after small indentation. With this new set-up, the different factors that may play a role in the onset of muscle damage can be studied, what we believe will lead to a better understanding of the contributing factors to pressure ulcer development.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Stekelenburg A,Oomens CW,Strijkers GJ,de Graaf L,Bader DL,Nicolay Kdoi
10.1016/j.medengphy.2005.07.005subject
Has Abstractpub_date
2006-05-01 00:00:00pages
331-8issue
4eissn
1350-4533issn
1873-4030pii
S1350-4533(05)00150-5journal_volume
28pub_type
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