Abstract:
:Neural networks are formed by accurate connectivity of neurons and glial cells in the brain. These networks employ a three-dimensional bio-surface that both assigns precise coordinates to cells during development and facilitates their connectivity and functionality throughout life. Using specific topographic and chemical features, we have taken steps towards the development of poly(dimethylsiloxane; PDMS) neurochips that can be used to generate and study synthetic neural networks. These neurochips have micropatterned structures that permit adequate cell positioning and support cell survival. Within days of plating, cells differentiate into neurons displaying excitability and communication, as evidenced by intracellular calcium oscillations and action potentials. The structural and functional capacities of such simple neural networks open up new opportunities to study synaptic communication and plasticity.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Bani-Yaghoub M,Tremblay R,Voicu R,Mealing G,Monette R,Py C,Faid K,Sikorska Mdoi
10.1002/bit.20618subject
Has Abstractpub_date
2005-11-05 00:00:00pages
336-45issue
3eissn
0006-3592issn
1097-0290journal_volume
92pub_type
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