Exact unconditional tables for significance testing in the 2 x 2 multinomial trial.

Abstract:

:This paper presents tables analogous to T-tables for use in the 2 x 2 multinomial trial, where the continuity corrected Z-statistic is used to make exact unconditional inference. This is the first solution of a discrete exact unconditional inference problem involving a multivariate nuisance parameter for which no ancillary statistic exists.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Shuster JJ

doi

10.1002/sim.4780110708

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

913-22

issue

7

eissn

0277-6715

issn

1097-0258

journal_volume

11

pub_type

杂志文章
  • A selection model for longitudinal binary responses subject to non-ignorable attrition.

    abstract::Longitudinal studies collect information on a sample of individuals which is followed over time to analyze the effects of individual and time-dependent characteristics on the observed response. These studies often suffer from attrition: individuals drop out of the study before its completion time and thus present inco...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3604

    authors: Alfò M,Maruotti A

    更新日期:2009-08-30 00:00:00

  • Heterogeneity in the probability of HIV transmission per sexual contact: the case of male-to-female transmission in penile-vaginal intercourse.

    abstract::Recent studies have indicated variation in the infectivity beta of HIV among heterosexual couples. We represent this heterogeneity by modelling beta as a random variable. Using data on the number of contacts and seroconversion of couples, we fit the model by maximum-likelihood estimation with a beta distribution and a...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780080110

    authors: Wiley JA,Herschkorn SJ,Padian NS

    更新日期:1989-01-01 00:00:00

  • Estimation of sojourn time distributions and false negative rates in screening programmes which use two modalities.

    abstract::Day and Walter derived methods of joint maximum likelihood estimation for the sojourn time distribution and the false negative rate for a screening programme. Their methods are not directly applicable to a programme which uses alternate screening by two modalities whose sojourn times and false negative rates will diff...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780080611

    authors: Alexander FE

    更新日期:1989-06-01 00:00:00

  • A joint model for interval-censored functional decline trajectories under informative observation.

    abstract::Multi-state models are useful for modelling disease progression where the state space of the process is used to represent the discrete disease status of subjects. Often, the disease process is only observed at clinical visits, and the schedule of these visits can depend on the disease status of patients. In such situa...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6582

    authors: Lesperance ML,Sabelnykova V,Nathoo FS,Lau F,Downing MG

    更新日期:2015-12-20 00:00:00

  • Discriminant analysis using a multivariate linear mixed model with a normal mixture in the random effects distribution.

    abstract::We have developed a method to longitudinally classify subjects into two or more prognostic groups using longitudinally observed values of markers related to the prognosis. We assume the availability of a training data set where the subjects' allocation into the prognostic group is known. The proposed method proceeds i...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3849

    authors: Komárek A,Hansen BE,Kuiper EM,van Buuren HR,Lesaffre E

    更新日期:2010-12-30 00:00:00

  • Flexible design clinical trial methodology in regulatory applications.

    abstract::Adaptive designs or flexible designs in a broader sense have increasingly been considered in planning pivotal registration clinical trials. Sample size reassessment design and adaptive selection design are two of such designs that appear in regulatory applications. At the design stage, consideration of sample size rea...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4021

    authors: Hung HM,Wang SJ,O'Neill R

    更新日期:2011-06-15 00:00:00

  • An adjustment for a post-randomization variable in the comparison of two treatments for survival.

    abstract::A method is proposed to infer the randomized treatment effect on survival after an adjustment for a post-randomization variable. The post-randomization variable is made independent of the treatment assignment and is considered a surrogate for baseline prognostic factors. The relationship between the post-randomization...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.968

    authors: Heller G

    更新日期:2001-11-30 00:00:00

  • Goodman and Kruskal's lambda: a new look at an old measure of association.

    abstract::We examine Goodman and Kruskal's lambda using Efron's approach to regression and analysis of variance (ANOVA) for zero-one outcome data. For a binary response cross-classified by a single nominal predictor, we present a computationally simple ANOVA table in which lambda is analogous to Pearson's R-square. We character...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780080511

    authors: Makuch RW,Rosenberg PS,Scott G

    更新日期:1989-05-01 00:00:00

  • Empirical evaluation of statistical models for counts or rates.

    abstract::We consider methods for selecting the joint specification of the mean and variance functions in statistical models for rates or counts. Based on analyses of diagnosis-specific hospital discharge rates in Michigan, we show that a Poisson model with an extra variance component for the systematic variation is superior to...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780100908

    authors: Wolfe RA,Petroni GR,McLaughlin CG,McMahon LF Jr

    更新日期:1991-09-01 00:00:00

  • Nonparametric comparison of two survival functions with dependent censoring via nonparametric multiple imputation.

    abstract::When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation using auxiliary variables to adjust for dependent censoring via multiple imputation, to the compari...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3480

    authors: Hsu CH,Taylor JM

    更新日期:2009-02-01 00:00:00

  • Robust fitting for neuroreceptor mapping.

    abstract::Among many other uses, positron emission tomography (PET) can be used in studies to estimate the density of a neuroreceptor at each location throughout the brain by measuring the concentration of a radiotracer over time and modeling its kinetics. There are a variety of kinetic models in common usage and these typicall...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3510

    authors: Chang C,Ogden RT

    更新日期:2009-03-15 00:00:00

  • Re-use of case-control data for analysis of new outcome variables.

    abstract::Case-control studies are usually defined to investigate risk factors for a single disease of interest. However, subsequent to data collection, investigators may wish to examine as an 'outcome' a variable that was an exposure in the original study. A naive analysis that disregards the sampling strategy that gave rise t...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.2398

    authors: Reilly M,Torrång A,Klint A

    更新日期:2005-12-30 00:00:00

  • A comparison of likelihood-based and marginal estimating equation methods for analysing repeated ordered categorical responses with missing data: application to an intervention trial of vitamin prophylaxis for oesophageal dysplasia.

    abstract::The purpose of this research was to develop appropriate methods for analysing repeated ordinal categorical data that arose in an intervention trial to prevent oesophageal cancer. The measured response was the degree of oesophageal dysplasia at 2.5 and 6 years after randomization. An important feature was that some res...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780130511

    authors: Mark SD,Gail MH

    更新日期:1994-03-15 00:00:00

  • Estimation of dynamic treatment strategies for maintenance therapy of children with acute lymphoblastic leukaemia: an application of history-adjusted marginal structural models.

    abstract::Childhood acute lymphoblastic leukaemia is treated with long-term intensive chemotherapy. During the latter part of the treatment, the maintenance therapy, the patients receive oral doses of two cytostatics. The doses are tailored to blood counts measured on a weekly basis, and the treatment is therefore highly dynami...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4393

    authors: Rosthøj S,Keiding N,Schmiegelow K

    更新日期:2012-02-28 00:00:00

  • Model-based multiplicity estimation of population size.

    abstract::A survey is conducted at w of K selection units or lists, e.g. health care institutions or weeks in a year, to estimate N, the total number of individuals with particular characteristics. Our estimator utilizes two items determined for each survey participant: the number, u, among the w lists in S and the number, j, a...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3614

    authors: Laska EM,Meisner M,Wanderling J

    更新日期:2009-07-30 00:00:00

  • Probabilistic cause-of-disease assignment using case-control diagnostic tests: A latent variable regression approach.

    abstract::Optimal prevention and treatment strategies for a disease of multiple causes, such as pneumonia, must be informed by the population distribution of causes among cases, or cause-specific case fractions (CSCFs). CSCFs may further depend on additional explanatory variables. Existing methodological literature in disease e...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.8804

    authors: Wu Z,Chen I

    更新日期:2021-02-20 00:00:00

  • Assessing goodness-of-fit of parametric regression models for lifetime data-graphical methods.

    abstract::Graphical methods are often used to check goodness-of-fit of models to data. It is common to plot residuals against a reference distribution so that when the model fits the data, the configuration should be close to a straight line. Since the resemblance to a straight line is often unclear, it has been suggested to ad...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780141607

    authors: Cohen A,Barnett O

    更新日期:1995-08-30 00:00:00

  • Comparison of operational characteristics for binary tests with clustered data.

    abstract::Although statistical methodology is well-developed for comparing diagnostic tests in terms of their sensitivity and specificity, comparative inference about predictive values is not. In this paper, we consider the analysis of studies comparing operating characteristics of two diagnostic tests that are measured on all ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6485

    authors: Kwak M,Um SW,Jung SH

    更新日期:2015-07-10 00:00:00

  • REML and ML estimation for clustered grouped survival data.

    abstract::Clustered grouped survival data arise naturally in clinical medicine and biological research. For example, in a randomized clinical trial, the variable of interest is the time to occurrence of a certain event with or without a new treatment and the data are collected from possibly correlated subjects from independent ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1323

    authors: Lam KF,Ip D

    更新日期:2003-06-30 00:00:00

  • Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

    abstract::A relationship between baseline risk and treatment effect is increasingly investigated as a possible explanation of between-study heterogeneity in clinical trial meta-analysis. An approach that is still often applied in the medical literature is to plot the estimated treatment effects against the estimated measures of...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/1097-0258(20001230)19:24<3497::aid-sim830>

    authors: Arends LR,Hoes AW,Lubsen J,Grobbee DE,Stijnen T

    更新日期:2000-12-30 00:00:00

  • Modeling hospital length of stay by Coxian phase-type regression with heterogeneity.

    abstract::Hospital length of stay (LOS) is an important measure of healthcare utilization and is generally positively skewed and heterogeneous. We fit a Coxian phase-type distribution to LOS and identify the hidden states of the underlying latent homogeneous Markov model. We demonstrate that selecting an appropriate number of p...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4490

    authors: Tang X,Luo Z,Gardiner JC

    更新日期:2012-06-30 00:00:00

  • Targeted maximum likelihood estimation for a binary treatment: A tutorial.

    abstract::When estimating the average effect of a binary treatment (or exposure) on an outcome, methods that incorporate propensity scores, the G-formula, or targeted maximum likelihood estimation (TMLE) are preferred over naïve regression approaches, which are biased under misspecification of a parametric outcome model. In con...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.7628

    authors: Luque-Fernandez MA,Schomaker M,Rachet B,Schnitzer ME

    更新日期:2018-07-20 00:00:00

  • Construction, validation and updating of a prognostic model for kidney graft survival.

    abstract::The construction, validation and updating of a prognostic model for kidney graft survival is reported using data from the Eurotransplant database. First, a model is constructed for data from transplantations in the period 1984 to 1987. The model is later updated for the 1988 1990 data. The first data set was randomly ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780141806

    authors: Van Houwelingen HC,Thorogood J

    更新日期:1995-09-30 00:00:00

  • A semi-Markov model for multistate and interval-censored data with multiple terminal events. Application in renal transplantation.

    abstract::The semi-Markov assumption emphasizes the importance of time spent in a state. In order to compute this type of multistate model, most transition times are always considered to be exactly identified or right censored. However, in the longitudinal analysis of chronic diseases, investigators are often confronted with in...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3100

    authors: Foucher Y,Giral M,Soulillou JP,Daures JP

    更新日期:2007-12-30 00:00:00

  • Dropouts in the AB/BA crossover design.

    abstract::Missing data arise in crossover trials, as they do in any form of clinical trial. Several papers have addressed the problems that missing data create, although almost all of these assume that the probability that a planned observation is missing does not depend on the value that would have been observed; that is, the ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4497

    authors: Ho WK,Matthews JN,Henderson R,Farewell D,Rodgers LR

    更新日期:2012-07-20 00:00:00

  • Quantifying the bias due to observed individual confounders in causal treatment effect estimates.

    abstract::It is often of interest to use observational data to estimate the causal effect of a target exposure or treatment on an outcome. When estimating the treatment effect, it is essential to appropriately adjust for selection bias due to observed confounders using, for example, propensity score weighting. Selection bias du...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.8549

    authors: Parast L,Griffin BA

    更新日期:2020-08-15 00:00:00

  • A pathway analysis method for genome-wide association studies.

    abstract::For genome-wide association studies, we propose a new method for identifying significant biological pathways. In this approach, we aggregate data across single-nucleotide polymorphisms to obtain summary measures at the gene level. We then use a hierarchical Bayesian model, which takes the gene-level summary measures a...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4477

    authors: Shahbaba B,Shachaf CM,Yu Z

    更新日期:2012-05-10 00:00:00

  • Traffic accident mapping in Bangkok metropolis: a case study.

    abstract::Results from an analysis of traffic accidents from a study of the police records of four police stations in the Bangkok metropolis are presented. The main emphasis in this study was put on the development of a measure for traffic accident density. The traffic flow was estimated at the various study locations by traine...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780142113

    authors: Ayuthya RS,Böhning D

    更新日期:1995-11-15 00:00:00

  • Risk-adjusted CUSUM charts under model error.

    abstract::In recent years, quality control charts have been increasingly applied in the healthcare environment, for example, to monitor surgical performance. Risk-adjusted cumulative (CUSUM) charts that utilize risk scores like the Parsonnet score to estimate the probability of death of a patient from an operation turn out to b...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.8104

    authors: Knoth S,Wittenberg P,Gan FF

    更新日期:2019-05-30 00:00:00

  • A new approach to designing phase I-II cancer trials for cytotoxic chemotherapies.

    abstract::Recently, there has been much work on early phase cancer designs that incorporate both toxicity and efficacy data, called phase I-II designs because they combine elements of both phases. However, they do not explicitly address the phase II hypothesis test of H0 : p ≤ p0 , where p is the probability of efficacy at the ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6124

    authors: Bartroff J,Lai TL,Narasimhan B

    更新日期:2014-07-20 00:00:00