Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.

abstract：:Several studies using sensitive in situ hybridization techniques show that, in non-immunocompromised patients, Epstein-Barr virus (EBV) is more frequently detected in lymphomas expressing T cell markers than in B cell lymphomas. Among lymphomas expressing T cell markers, the presence of EBV is highly related to the si...

journal_title：Leukemia

authors： Kanavaros P,Briere J,Emile JF,Gaulard P

更新日期：1996-06-01 00:00:00

abstract：:We studied both serum-free colony-forming unit-megakaryocyte (CFU-meg) numbers and serum thrombopoietin (TPO) levels in 14 patients with aplastic anemia (AA), 37 patients with myelodysplastic syndromes (MDS) and 23 patients with idiopathic thrombocytopenic purpura (ITP) to assess thrombopoiesis in these thrombocytopen...

journal_title：Leukemia

authors： Wang W,Matsuo T,Yoshida S,Mori H,Miyazaki Y,Kuriyama K,Tomonaga M

更新日期：2000-10-01 00:00:00

abstract：:Event-free survival (EFS) at 5 years in pediatric acute lymphoblastic leukemia (ALL) is >80%. Outcome in adult ALL is still unsatisfactory, which is due to less cumulative dosing of chemotherapy and less strict adherence to timing of successive cycles. In the present phase II trial, we evaluated a pediatric regimen in...

journal_title：Leukemia

authors： Rijneveld AW,van der Holt B,Daenen SM,Biemond BJ,de Weerdt O,Muus P,Maertens J,Mattijssen V,Demuynck H,Legdeur MC,Wijermans PW,Wittebol S,Spoelstra FM,Dekker AW,Ossenkoppele GJ,Willemze R,Cornelissen JJ,Dutch-Belgian HO

更新日期：2011-11-01 00:00:00

abstract：:Clonal chromosome abnormalities were detected in bone marrow cells of 20 patients with Fanconi anemia investigated at various stages of the disease. Two presented with acute leukemia, six with myelodysplastic syndrome, and 12 had minor or no morphological abnormalities of hematopoietic cells. Abnormalities of chromoso...

journal_title：Leukemia

authors： Maarek O,Jonveaux P,Le Coniat M,Derré J,Berger R

更新日期：1996-11-01 00:00:00

abstract：:Imatinib is a highly effective therapy for chronic phase-chronic myeloid leukaemia (CP-CML) patients; however, responses to frontline imatinib are variable. The human organic cation transporter 1 (OCT1; SLC22A1) has been reported to be the main influx transporter involved in imatinib uptake into CML cells. Furthermore...

journal_title：Leukemia

authors： Watkins DB,Hughes TP,White DL

更新日期：2015-10-01 00:00:00

abstract：:Trisomy 12 is the most common chromosomal aberration in chronic B lymphocytic leukemia (B-CLL). In this study we have investigated trisomy 12 and posed two major questions: (a) What is the origin of the third copy of chromosome 12? and (b) What is the proportion of trisomy 12 cells in malignant clones with this aberra...

journal_title：Leukemia

authors： Einhorn S,Burvall K,Juliusson G,Gahrton G,Meeker T

更新日期：1989-12-01 00:00:00

abstract：:Terminal blast crisis cells of chronic granulocytic leukemia are biochemically distinct. Triton-X-114 detergent phase lysates revealed that myeloid types express predominantly proteins of a 24 kd apparent molecular weight range, whereas lymphatic types do not express these molecules but a 55 kd protein band. These bio...

journal_title：Leukemia

authors： Doxiadis I,Dölken P,Schneider M,Wernet P,Grosse-Wilde H

更新日期：1988-12-01 00:00:00

abstract：:We have sought the presence of rearrangements of the immunoglobulin heavy chain gene locus in 13 patients with chronic myeloid leukemia (CML) in lymphoid blastic transformation (L-BT) using the polymerase chain reaction (PCR). The lymphoid nature of the transformation was confirmed by immunophenotyping and/or Southern...

journal_title：Leukemia

authors： Spencer A,Vulliamy T,Kaeda J,Goldman JM,Melo JV

更新日期：1997-02-01 00:00:00

abstract：:The number of allogeneic transplants from unrelated donors has grown in the past decade in part because of the expansion of the donor registry size. Patient survival has improved due to the selection of more closely matched donors and the development of effective infection prophylaxis. Relapse-free survival remains li...

journal_title：Leukemia

authors： Anasetti C

更新日期：2000-03-01 00:00:00

abstract：:Neutropenia-related fungal infections can be life-threatening despite antifungal therapy. We evaluated the role of recombinant granulocyte colony-stimulating factor (rG-CSF)-elicited white blood cell (WBC) transfusions in patients with neutropenia-related fungal infections. Adult patients with hematologic malignancies...

journal_title：Leukemia

authors： Dignani MC,Anaissie EJ,Hester JP,O'Brien S,Vartivarian SE,Rex JH,Kantarjian H,Jendiroba DB,Lichtiger B,Andersson BS,Freireich EJ

更新日期：1997-10-01 00:00:00

abstract：:Currently available data regarding the substrate specificity of the multi-drug resistance (MDR) mechanisms P-glycoprotein (Pgp) and MDR-associated protein (MRP1) for idarubicin are inconclusive. A multiparameter flow cytometry method was developed which allows simultaneous quantitative measurement of total cellular fl...

journal_title：Leukemia

authors： Smeets ME,Raymakers RA,Vierwinden G,Pennings AH,Boezeman J,Minderman H,de Witte TM

更新日期：1999-09-01 00:00:00

abstract：:Although current treatments can induce clinical complete remissions in the vast majority of patients with indolent lymphoma, most of them actually relapse, because of the persistence of residual tumor cells which are undetectable using conventional diagnostic procedures. Polymerase chain reaction (PCR)-based methods a...

journal_title：Leukemia

authors： Corradini P,Ladetto M,Pileri A,Tarella C

更新日期：1999-11-01 00:00:00

abstract：:ET is a chronic myeloproliferative disorder rarely evolving into AML, sometimes preceded by a myelodysplastic syndrome (MDS). Such transformations mostly occur in patients treated with radiophosphorous ((32)P) or alkylating agents, especially busulfan. Recently, concern has also arisen about the long-term safety of hy...

journal_title：Leukemia

authors： Bernasconi P,Boni M,Cavigliano PM,Calatroni S,Brusamolino E,Passamonti F,Volpe G,Pistorio A,Giardini I,Rocca B,Caresana M,Lazzarino M,Bernasconi C

更新日期：2002-10-01 00:00:00

abstract：:Hemizygous deletions are common molecular abnormalities in cancer. In some cases, these deletions highlight chromosomal loci containing tumor suppressor genes that undergo homozygous inactivation. In other cases, hemizygous deletions cause disease by allelic insufficiency for one or more genes. As the intact allele ha...

journal_title：Leukemia

authors： Ebert BL

更新日期：2009-07-01 00:00:00

abstract：:Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the pathogenesis of chronic lymphocytic leukemia (CLL). Given the emerging multifarious interactions between CLL and bystander T cells, we sought to determine whether antigen(s) are also selecting T cells in CLL. We performed a larg...

journal_title：Leukemia

authors： Vardi A,Vlachonikola E,Karypidou M,Stalika E,Bikos V,Gemenetzi K,Maramis C,Siorenta A,Anagnostopoulos A,Pospisilova S,Maglaveras N,Chouvarda I,Stamatopoulos K,Hadzidimitriou A

更新日期：2017-07-01 00:00:00

abstract：:Less-intense remission induction regimens for adults with newly diagnosed acute myeloid leukemia (AML) aim to reduce treatment-related mortality (TRM), here defined as death within 4 weeks after starting induction therapy. This assumes that TRM rates are similar to the 15-20% observed 20 years ago. Herein we test this...

journal_title：Leukemia

authors： Othus M,Kantarjian H,Petersdorf S,Ravandi F,Godwin J,Cortes J,Pierce S,Erba H,Faderl S,Appelbaum FR,Estey E

更新日期：2014-02-01 00:00:00

abstract：:Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15-~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate mechanisms triggering BCL2 expression and promoting pathogenesis in t(14;18)-negative FL, exonic single-nucleotide variant (SNV) profiles of 28 t(14;18)-positive and ...

journal_title：Leukemia

authors： Zamò A,Pischimarov J,Schlesner M,Rosenstiel P,Bomben R,Horn H,Grieb T,Nedeva T,López C,Haake A,Richter J,Trümper L,Lawerenz C,Klapper W,Möller P,Hummel M,Lenze D,Szczepanowski M,Flossbach L,Schreder M,Gattei V,O

更新日期：2018-03-01 00:00:00

abstract：:The notion that inherited predisposition contributes to the development of haematological malignancies is generally thought of as being a relatively new idea. However, Videbaek made a clear enunciation of such a hypothesis in 1947, from a study of tumour incidence in relatives of patients with different leukaemias. To...

journal_title：Leukemia

authors： Jønsson V,Houlston RS,Catovsky D,Yuille MR,Hilden J,Olsen JH,Fajber M,Brandt B,Sellick G,Allinson R,Wiik A

更新日期：2005-06-01 00:00:00

abstract：:A mutational analysis of the delta region of the Jun protein shows an inverse correlation between transforming and transactivation potential of the mutant proteins if both properties are measured in chicken embryo fibroblasts. The possibility that Jun acquires oncogenicity not by gain but by loss of function is also s...

journal_title：Leukemia

authors： Vogt PK,Morgan IM,Håvarstein L,Su H,Hartl M,Schuur E

更新日期：1992-01-01 00:00:00

abstract：:There is a clear association between the Epstein-Barr virus (EBV) and Hodgkin's disease (HD). EBV is not, however, detectable within the affected tissues of all cases. The proportion of positive cases varies from 15-79% depending on the assay used to detect EBV. The techniques utilised vary not only in sensitivity but...

journal_title：Leukemia

authors： Armstrong AA,Weiss LM,Gallagher A,Jones DB,Krajewski AS,Angus B,Brown G,Jack AS,Wilkins BS,Onions DE

更新日期：1992-09-01 00:00:00

abstract：:The translocation (14;18)(q32;q21) is the hallmark of follicular lymphoma (FL). However, conventional cytogenetics and PCR techniques fail to detect it in at least 10% of cases. In order to evaluate the true incidence of this translocation in FL, we analyzed 63 patients with FL, and 17 patients with diffuse large cell...

journal_title：Leukemia

authors： Godon A,Moreau A,Talmant P,Baranger-Papot L,Geneviève F,Milpied N,Zandecki M,Avet-Loiseau H

更新日期：2003-01-01 00:00:00

abstract：:In a 56-year-old male patient, receiving chemotherapy after radical surgery for bladder carcinoma, an unusual type of cytoplasmic inclusion was discovered in about 30% of peripheral blood lymphocytes. This was a single, large (about 2 microns in diameter), round or ovoid body, darker than the nucleus and reddish-viole...

journal_title：Leukemia

authors： Rozman M,Vives-Corrons JL,Germá JR,Colomer D,Villamor N,Rozman C

更新日期：1994-12-01 00:00:00

abstract：:Polymerase chain reaction (PCR) techniques based on amplification and identification of leukemia-specific DNA sequences provide a sensitive diagnostic method for detection of minimal residual disease (MRD) with a detection limit of 10(-5) to 10(-6) (1-10 malignant cells in 10(6) normal cells). To date, the main leukem...

journal_title：Leukemia

authors： Breit TM,Beishuizen A,Ludwig WD,Mol EJ,Adriaansen HJ,van Wering ER,van Dongen JJ

更新日期：1993-12-01 00:00:00

abstract：:Specific myeloid-related and inositide-specific gene mutations can be linked to myelodysplastic syndromes (MDS) pathogenesis and therapy. Here, 44 higher-risk MDS patients were treated with azacitidine and lenalidomide and mutations analyses were performed at baseline and during the therapy. Results were then correlat...

journal_title：Leukemia

authors： Follo MY,Pellagatti A,Armstrong RN,Ratti S,Mongiorgi S,De Fanti S,Bochicchio MT,Russo D,Gobbi M,Miglino M,Parisi S,Martinelli G,Cavo M,Luiselli D,McCubrey JA,Suh PG,Manzoli L,Boultwood J,Finelli C,Cocco L

更新日期：2019-09-01 00:00:00

abstract：:The NUP214-ABL1 fusion kinase has recently been identified in 6% of patients with T-cell acute lymphoblastic leukemia. In contrast to the more common oncogenic ABL1 fusion BCR-ABL1, NUP214-ABL1 localizes to the nuclear pore complexes and has attenuated transforming properties in hematopoietic cells and in mouse bone m...

journal_title：Leukemia

authors： De Keersmaecker K,Versele M,Cools J,Superti-Furga G,Hantschel O

更新日期：2008-12-01 00:00:00

abstract：:The translocation t(11;20)(p15;q11) was found as the sole acquired clonal chromosome abnormality in two patients with acute myeloid leukemia. The bone marrow morphology in both cases corresponded to the M2 subtype of the French-American-British (FAB) classification. None of the patients achieved complete remission, an...

journal_title：Leukemia

authors： Mitelman F,Prigogina EL,Fleischman EW,Frenkel MA,Garwicz S,Heim S,Ilyinskaya GW,Kristoffersson U,Mandahl N,Volkova MA

更新日期：1988-07-01 00:00:00

abstract：:Chromosomal breakpoints associated with malignancy are known to cluster at particular regions of the karyotype. Based on a review of the literature we have identified a novel leukaemia syndrome associated with translocations involving 8p11. This syndrome is distinct from the previously described translocation t(8;16)(...

journal_title：Leukemia

authors： Macdonald D,Aguiar RC,Mason PJ,Goldman JM,Cross NC

更新日期：1995-10-01 00:00:00

abstract：:A 32-year-old white woman was admitted with a diagnosis of T lymphoblastic lymphoma and a bone marrow and peripheral blood cytology that was suggestive of a myeloproliferative syndrome (MPS). In addition, islets of myeloid precursors were found in the lymph node where the lymphoma had been diagnosed. Cytogenetic exami...

journal_title：Leukemia

authors： Behringer D,Schaefer HE,Kunzmann R,Mertelsmann R,Dölken G

更新日期：1995-06-01 00:00:00

abstract：:Retroviral gene transfer into hematopoietic cells has many experimental as well as clinical applications. Although transduction efficiency of retroviral vectors is higher than with conventional methods, selection of successfully transduced cells may become mandatory for efficient in vivo transfer. We have been evaluat...

journal_title：Leukemia

authors： Flasshove M,Banerjee D,Bertino JR,Moore MA

更新日期：1995-10-01 00:00:00

abstract：:Commercial human chorionic gonadotrophin (HCG) preparations decrease the tumorigenicity of human tumors in immunodeficient mice and induce apoptotic cell death in animal tumor models. Preliminary studies in humans have demonstrated tumor regression in patients with Kaposi's sarcoma given intralesional injections of HC...

journal_title：Leukemia

authors： Feldman EJ,Seiter K,Chiao JW,Halicka HD,Traganos F,Fatora SR,McMichael J,Baskind P,Goff H,Beer M,Ahmed T,Darzynkiewicz Z

更新日期：1998-11-01 00:00:00