Abstract:
:We report a 13-year-old girl who presented with hepatic failure and hemolytic anemia. Laboratory findings showed a normal serum copper level (104 microg/dl), high urinary copper level (2370 microg/dl), and low serum ceruloplasmin level (14.3 microg/dl). Slit-lamp examination revealed Kayser-Fleischer rings on her cornea, and she was diagnosed with Wilson's disease. Plasma exchange and continuous hemodiafiltration relieved the serious condition, after that laparoscopic examination was performed. Administration of D-penicillamine and restriction of dietary copper (<1 mg/day) were started, leading to a normalized serum alanine amino transferase (ALT) level. After 3 years, she again underwent laparoscopic examination, and the laparoscopic and histological findings of her liver were obviously improved. Management of the copper level can reverse severe liver fibrosis in Wilson's disease.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Sakaida I,Kawaguchi K,Kimura T,Tamura F,Okita Kdoi
10.1007/s00535-005-1600-5subject
Has Abstractpub_date
2005-06-01 00:00:00pages
646-51issue
6eissn
0944-1174issn
1435-5922journal_volume
40pub_type
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