The latest on functional imaging studies of aphasic stroke.

abstract：PURPOSE OF REVIEW:New insights into the psychophysiological determinants of performance changes and brain plasticity associated with motor sequence learning have recently been gained through behavioral and imaging studies in healthy individuals. In addition, using a variety of motor sequential paradigms in groups of pa...

journal_title：Current opinion in neurology

authors： Doyon J

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced MR sequences allows the characterization of diverse and complex pathological mechanisms, gra...

journal_title：Current opinion in neurology

authors： Inglese M,Petracca M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Cervical spondylotic myelopathy (CSM) is a potentially debilitating disorder primarily related to spinal cord injury caused by degenerative changes of the spine. As the population continues to age and live longer, it is likely that this disorder will be encountered with increasing frequency. RECENT F...

journal_title：Current opinion in neurology

authors： Holly LT

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Migraine has traditionally been categorized as a pain disorder, focusing on headache as its central feature. This narrow view does not account for the complex array of premonitory and postrdromal symptoms that occur in the hours before and after headache. This review outlines evidence that supports a ...

journal_title：Current opinion in neurology

authors： Charles A

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The results of phase 2 randomized controlled trials for the prevention of episodic and chronic migraine demonstrating the efficacy and safety of four mAbs targeting the calcitonin gene-related peptide (CGRP) pathway [ALD403 (eptinezumab), AMG334 (erenumab), LY2951742 (galcanezumab) and TEV48125 (frema...

journal_title：Current opinion in neurology

authors： Mitsikostas DD,Reuter U

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the most important issues a clinician must consider whenever selecting and administering antiepileptic drugs (AEDs). There is no available algorithm that identifies how to individualize selection of AEDs. Proper selection and administration can make an enormous difference in both effective...

journal_title：Current opinion in neurology

authors： Cheng JY,French JA

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The trigeminal autonomic reflex is a physiological reflex with an important protective function which also plays a role in pathophysiological conditions, such as primary headache. It is not understood whether the autonomic symptoms in trigeminal autonomic cephalalgias and migraine are the consequence ...

journal_title：Current opinion in neurology

authors： Möller M,May A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Small vessel diseases of the brain are still clinically underrecognized whereas their burden is increasing steeply. The most frequent is acquired degenerative small vessel disease. Many hereditary or idiopathic small vessel diseases have also been identified, of which cerebral autosomal-dominant arter...

journal_title：Current opinion in neurology

authors： Ringelstein EB,Nabavi DG

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cerebral amyloid angiopathy (CAA) is diagnosed primarily as a cause of lobar intracerebral hemorrhages (ICH) in elderly patients. With improving MRI techniques, however, the role of CAA in causing other symptoms has become clear. Recognizing the full clinical spectrum of CAA is important for diagnosis...

journal_title：Current opinion in neurology

authors： Wermer MJH,Greenberg SM

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the application of advanced MRI sequences such as magnetic resonance spectroscopy, diffusion tensor imaging and functional MRI for the evaluation of patients with altered consciousness. RECENT FINDINGS:Magnetic resonance spectroscopy, volumetry and diffusion tensor imaging have shown pro...

journal_title：Current opinion in neurology

authors： Galanaud D,Naccache L,Puybasset L

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review will outline neuroprotective and neurotoxic effects of central nervous system (CNS) infiltrating T cells during viral infections. Evidence demonstrating differential roles for antiviral effector and resident memory T-cell subsets in virologic control and immunopathology in the CNS w...

journal_title：Current opinion in neurology

authors： Ai S,Klein RS

更新日期：2020-06-01 00:00:00

abstract：:This article reviews recent studies evaluating the clinicopathologic markers of progressive supranuclear palsy, which have helped establish standardized clinical and pathologic diagnostic criteria. Although these criteria increase diagnostic accuracy, the clinical and pathologic overlap between progressive supranuclea...

journal_title：Current opinion in neurology

authors： Litvan I

更新日期：1997-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The computational power of the brain arises from the complex interactions between neurons. One straightforward method to quantify the strength of neuronal interactions is by measuring correlation and coherence. Efforts to measure correlation have been advancing rapidly of late, spurred by the developm...

journal_title：Current opinion in neurology

authors： Snyder AC,Smith MA

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we summarize the evidence from human studies of the impairments to the structural, functional, and metabolic capacities in skeletal muscle in those with type 1 diabetes (T1D) - a condition known as diabetic myopathy. Given the importance of skeletal muscle for blood lipid and glucose management, ...

journal_title：Current opinion in neurology

authors： Monaco CMF,Perry CGR,Hawke TJ

更新日期：2017-10-01 00:00:00

abstract：:Demyelination and inflammation both contribute to the neurological deficits characteristic of multiple sclerosis and Guillain-Barré syndrome. Conduction deficits attributable to demyelination are well known, but it is becoming clear that factors such as nitric oxide, endocaine, cytokines, and antiganglioside antibodie...

journal_title：Current opinion in neurology

authors： Smith KJ,Hall SM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss aspects of cytokine networks in neuroinflammatory diseases and attempt to provide some explanation for our failures and successes in translating preclinical data to benefit patients with multiple sclerosis (MS). We will discuss innate cytokines such as tumor necrosis factor al...

journal_title：Current opinion in neurology

authors： Codarri L,Fontana A,Becher B

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of chemotherapy in low-grade glioma has been redefined with the long-term follow-up of the RTOG 9802, which investigated adjuvant procarbazine, CCNU, and vincristine (PCV) chemotherapy in addition to radiotherapy, and the results of EORTC trial 22033 in a similar patient population that compa...

journal_title：Current opinion in neurology

authors： van den Bent MJ

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

journal_title：Current opinion in neurology

authors： Gallo V,Armstrong RC

更新日期：2008-06-01 00:00:00

abstract：:Multiple sclerosis is a common neurological disorder that represents a significant source of disability. B cells have recently emerged as a novel therapeutic target for multiple sclerosis. The natural development of B cells is characterized by an antigen-independent phase that occurs in the bone marrow and an antigen-...

journal_title：Current opinion in neurology

authors： Monson NL

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent advances in the diagnostic approaches and the underlying pathophysiological mechanisms of Charcot-Marie-Tooth (CMT) disease. We also discuss the emerging therapies for this hereditary neuropathy. RECENT FINDINGS:To date, numerous genes are implicated in CMT, and new gene...

journal_title：Current opinion in neurology

authors： Vallat JM,Mathis S,Funalot B

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Central nervous system infections are not uncommon in systemic vasculitides. Being vigilant of central nervous system infections as an alternative consideration, instead of systemic vasculitides per se, could prove to be lifesaving in certain circumstances. RECENT FINDINGS:Common pathogens, such as t...

journal_title：Current opinion in neurology

authors： Ye S,Yang CD

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Gadolinium-enhancement depicts blood-brain barrier disruption associated with new inflammatory MRI lesions in multiple sclerosis (MS) and is widely used for diagnosis and therapeutic monitoring. However, earlier and more specific markers of inflammation are urgently needed. RECENT FINDINGS:Susceptibi...

journal_title：Current opinion in neurology

authors： Hagens M,van Berckel B,Barkhof F

更新日期：2016-06-01 00:00:00

abstract：:New functional imaging techniques, including positron emission tomography, transcranial magnetic stimulation and functional magnetic resonance imaging, promise to allow the noninvasive study of haemodynamic, metabolic and activation parameters during acute migraine attacks in humans. These techniques are currently bei...

journal_title：Current opinion in neurology

authors： Cutrer FM,O'Donnell A

更新日期：1999-06-01 00:00:00

abstract：:Recent advances in clinical neurophysiology of epilepsy have enhanced our ability to study the epileptogenic region and have improved the localization of seizures in patients with intractable epilepsy. Computed spike analyses using electroencephalogram or magnetoencephalography superimposed on magnetic resonance image...

journal_title：Current opinion in neurology

authors： Masuoka LK,Spencer SS

更新日期：1994-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with asymptomatic carotid stenosis are at increased vascular risk but optimal treatment is controversial. We reviewed the current evidence for medical and surgical intervention in these patients. RECENT FINDINGS:Optimal medical treatment is the most important aspect of management of patients...

journal_title：Current opinion in neurology

authors： Redgrave JN,Rothwell PM

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent advances in survival for patients with newly diagnosed and recurrent brain tumors, combined with the development of an ever-increasing number of potential treatments, has led to significant growth in the number of clinical trials for patients with brain tumors. Suitable clinical trial design an...

journal_title：Current opinion in neurology

authors： Butowski N,Chang SM

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In recent years, advances in the understanding of the regulatory mechanisms of the immune system has led to the development of new approaches for cancer treatment. Currently, immune checkpoint inhibitors are the first successful examples of this approach and several agents that target cytotoxic lympho...

journal_title：Current opinion in neurology

authors： Hottinger AF

更新日期：2016-12-01 00:00:00

abstract：:Slowly, advances are being made in the understanding and treatment of primary childhood brain tumors. The addition of chemotherapy has resulted in better survival for children with medulloblastoma. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy is increasingly being employed to tr...

journal_title：Current opinion in neurology

authors： Packer RJ

更新日期：1997-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Converging evidence from animal models of stroke and clinical trials suggests that aerobic exercise has effects across multiple targets. RECENT FINDINGS:The subacute phase is characterized by a period of heightened neuroplasticity when aerobic exercise has the potential to optimize recovery. In anima...

journal_title：Current opinion in neurology

authors： Ploughman M,Kelly LP

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

journal_title：Current opinion in neurology

authors： Schofield TM,Leff AP

更新日期：2009-02-01 00:00:00