Abstract:
:The success of treatment of patients with cancer depends on establishing an accurate diagnosis. To this end, we have built a system called GEMS (gene expression model selector) for the automated development and evaluation of high-quality cancer diagnostic models and biomarker discovery from microarray gene expression data. In order to determine and equip the system with the best performing diagnostic methodologies in this domain, we first conducted a comprehensive evaluation of classification algorithms using 11 cancer microarray datasets. In this paper we present a preliminary evaluation of the system with five new datasets. The performance of the models produced automatically by GEMS is comparable or better than the results obtained by human analysts. Additionally, we performed a cross-dataset evaluation of the system. This involved using a dataset to build a diagnostic model and to estimate its future performance, then applying this model and evaluating its performance on a different dataset. We found that models produced by GEMS indeed perform well in independent samples and, furthermore, the cross-validation performance estimates output by the system approximate well the error obtained by the independent validation. GEMS is freely available for download for non-commercial use from http://www.gems-system.org.
journal_name
Int J Med Informjournal_title
International journal of medical informaticsauthors
Statnikov A,Tsamardinos I,Dosbayev Y,Aliferis CFdoi
10.1016/j.ijmedinf.2005.05.002subject
Has Abstractpub_date
2005-08-01 00:00:00pages
491-503issue
7-8eissn
1386-5056issn
1872-8243pii
S1386-5056(05)00052-3journal_volume
74pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to develop a prototype personal digital assistant-decision support system (PDA-DSS) based on a clinical practice guideline (CPG) for the management of obesity. DESIGN:The study was composed of four phases: (1) analysis of advanced practice nurse (APN) students' documentation rel...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2007.05.009
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Currently, it is rare for nursing data to be available in data repositories due to the quality of nursing data collected in clinical practice. To improve the quality of nursing data, the American Nurses Association recommends the use of Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) for cod...
journal_title:International journal of medical informatics
pub_type: 杂志文章,评审
doi:10.1016/j.ijmedinf.2019.104035
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:We aim to 1) design an evaluation framework to examine the accuracy of automatic privacy auditing tools, 2) apply the evaluation method at a hospital to validate the performance of an auditing tool that uses a machine learning algorithm to automate user access auditing, and 3) recommend further improvements i...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2020.104123
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To compare the usability of different Picture Archiving and Communication System (PACS) workstations, determine whether a usability test has added value with respect to the traditional way of comparing PACSs based on functional requirements, and to evaluate the appropriateness of a task-based methodology for...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2013.10.003
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:This survey among an interdisciplinary group of clinicians was conducted to obtain their opinions about the usefulness of decision support systems (DSS) for evidence- and patient preference-based illness management, factors important to their implementation, and criteria for evaluating their effectiveness. MET...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2004.08.004
更新日期:2004-11-01 00:00:00
abstract:INTRODUCTION:Clinicians commonly use the modified Rankin Scale (mRS) and the Barthel Index (BI) to measure clinical outcome after stroke. These are potential targets in machine learning models for stroke outcome prediction. Therefore, the quality of the measurements is crucial for training and validation of these model...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2019.103988
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Researches on Lifestyle medicine (LM) have emerged in recent years to garner wide attention. Prostate cancer (PCa) could be prevented and treated by positive lifestyles, but the association between lifestyles and PCa is always personalized. OBJECTIVES:In order to solve the heterogeneity and diversity of dif...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2020.104332
更新日期:2021-01-01 00:00:00
abstract::In the last years, multidisciplinary post-discharge treatment programs, such as telemonitoring, have been promoted as a strategy for Heart Failure (HF) management. However, the distinctive requirements that a telemonitoring system should have, have not been clearly identified. To this aim, the most relevant requiremen...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2020.104204
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Electronic health record (EHR) systems are often modified through the addition of new features over time. Few studies have examined the specific effects of such changes. We examined whether implementation of a bidirectional laboratory interface for order entry and data reporting within an existing ambulatory...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2012.07.012
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Heuristic evaluation (HE) is an inspection method that can be used for identifying usability problems of health information systems. There is insufficient evidence to what extent these problems are experienced by users in their working environment. The objective of this study was to investigate the agreement ...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2018.05.012
更新日期:2018-09-01 00:00:00
abstract::To assure sustainability of our health systems and improve quality, implementing integrated wellness, health and social care service models have been proposed. They will need the enabling power of Health ICT facilitated systems and applications. Such solutions support the efficient coordination of service provision ac...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2012.05.008
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Reliability of diagnoses coding is essential for the use of routine data in a national health care system. The present investigation compares reliability of diagnoses coding with ICD-10 between three groups of coding subjects. METHOD:One hundred and eighteen students coded 15 diagnoses lists, 27 medical mana...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2006.11.005
更新日期:2008-01-01 00:00:00
abstract::A usable medical information system should allow for reliable and accurate interaction between users and the system in emergencies. A participatory design approach was used to develop a medical information system in two Turkish hospitals. The process consisted of task and user analysis, an icon design survey, initial ...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2011.08.005
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To develop an economic model of health care professional demand for knowledge capital in health informatics. DESIGN:Case study with application of the contingent valuation method to develop a small-scale model. SETTING:Specialized clinic at a university Hospital in Sweden. RESULTS:The model displays the ec...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/s1386-5056(98)00151-8
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:The speed and high potential impact of avian influenza's (AI) on local bird populations, poultry economies and human health make timely and coordinated characterization, assessment and response to possible threats essential. To collaborate effectively, stakeholders (public health, medical, veterinary, and agric...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2008.06.015
更新日期:2009-03-01 00:00:00
abstract::A multimedia system used as an auxiliary didactic tool for teaching medical genetics, HGEN, is based on non-linear programmed instruction and multimedia. HGEN was implemented in layers for PC compatible using MULTIMEDIA TOOLBOOK and DELPHI. It includes basic medical genetics concepts (inheritance patterns and cytogene...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/s1386-5056(98)00077-x
更新日期:1998-06-01 00:00:00
abstract::Evidence-based dentistry has shown that different restorative materials have different survival times. Our primary hypothesis is that this should be revealed from normal dental records by the use of data mining technique and a practice-based dentistry approach analysed in a scientifically sound way. Dental records fro...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2009.04.004
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:The authors have been conducting text mining analyses (extraction of useful information from text) of Medline records, using Abstracts as the main data source. For literature-based discovery, and other text mining applications as well, all records in a discipline need to be evaluated for determining prior ar...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2004.02.008
更新日期:2004-06-30 00:00:00
abstract:PURPOSE:Despite the amount of health information available online, there are several barriers that limit the Internet from being adopted as a source of health information. The purpose of this study was to identify individual skill-related problems that users experience when accessing the Internet for health information...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2011.10.005
更新日期:2012-01-01 00:00:00
abstract::In order to increase the number of practical and discussion classes offered to students in the traditional-curriculum scenario, while decreasing the lecture-based ones and to create an online community to share knowledge on surgery, we developed and assessed the first online course for undergraduate medical students o...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2004.06.002
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To develop a powerful archetype editing framework capable of handling multiple reference models and oriented towards the semantic description and standardization of legacy data. METHODS:The main prerequisite for implementing tools providing enhanced support for archetypes is the clear specification of archetyp...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2009.03.006
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To assess problem list completeness using an objective measure across a range of sites, and to identify success factors for problem list completeness. METHODS:We conducted a retrospective analysis of electronic health record data and interviews at ten healthcare organizations within the United States, United...
journal_title:International journal of medical informatics
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ijmedinf.2015.06.011
更新日期:2015-10-01 00:00:00
abstract::A computerised record hash coding and linkage procedure is proposed to allow the chaining of medical information within the framework of epidemiological follow-up. Before their extraction, files are rendered anonymous using a one-way hash coding based on the standard hash algorithm (SHA) function, in order to respect ...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/s1386-5056(98)00019-7
更新日期:1998-03-01 00:00:00
abstract::The process of generating a clinical referral for a patient, and the resulting transfer of information from the primary care physician to the specialist and back again, are key components in the struggle to deliver less costly and more effective clinical care. We have created a computer-based, outpatient clinical refe...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/s1386-5056(99)00027-1
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Serious games (SGs) are a type of simulation technology that may provide nursing students with the opportunity to practice their clinical reasoning and decision-making skills in a safe and authentic environment. Despite the growing number of SGs developed for healthcare professionals, few SGs are video based...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2016.06.014
更新日期:2016-10-01 00:00:00
abstract::Telehealth refers to the integration of information, telecommunication, human-machine interface technologies and health technologies to deliver health care, to promote the heath status of the people and to create health. The Malaysian Telehealth Application will, on completion, provide every resident of the country an...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2003.11.023
更新日期:2004-03-31 00:00:00
abstract:OBJECTIVE:To develop a comprehensive instrument assessing quality of health-related web sites. METHODS:Phase I consisted of a literature review to identify constructs thought to indicate web site quality and to identify items. During content analysis, duplicate items were eliminated and items that were not clear, mean...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2005.07.034
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Medical language, as many technical languages, is rich with morphologically complex words, many of which take their roots in Greek and Latin--in which case they are called neoclassical compounds. Morphosemantic analysis can help generate definitions of such words. The similarity of structure of those compounds ...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2008.07.016
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:When developing Information and Communication Technology (ICT), such as services for the decision-making process, skilled health care professionals with their comprehensive knowledge of patients/clients are essential contributors to the project. Careful evaluation is needed to assess the effectiveness of pro...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2005.07.002
更新日期:2005-12-01 00:00:00
abstract:INTRODUCTION:In this article we begin by connecting the concept of simplicity of user interfaces of information systems with that of usability, and the concept of complexity of the problem-solving in information systems with the concept of usefulness. We continue by stating "the usability axiom" of medical information ...
journal_title:International journal of medical informatics
pub_type: 杂志文章
doi:10.1016/j.ijmedinf.2006.05.039
更新日期:2006-12-01 00:00:00