Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia.

abstract：RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and ga...

journal_title：Circulation research

authors： Ren X,Ustiyan V,Pradhan A,Cai Y,Havrilak JA,Bolte CS,Shannon JM,Kalin TV,Kalinichenko VV

更新日期：2014-09-26 00:00:00

abstract：:We studied the specificity of uptake of infarct-imaging agents for reversibly or irreversibly injured myocardium independently of blood flow by using intact beating fetal mouse hearts in organ culture. Reversible injury resulted from deprivation of oxygen and glucose for 4 hours at 37 degrees C; irreversible injury, f...

journal_title：Circulation research

authors： Schelbert HR,Ingwall JS,Sybers HD,Ashburn WL

更新日期：1976-12-01 00:00:00

abstract：:Local alterations in the hemodynamic environment regulate endothelial cell function, but the signal-transduction mechanisms involved in this process remain unclear. Because mitogen-activated protein (MAP) kinases have been shown to be activated by physical forces, we measured the phosphorylation and enzyme activity of...

journal_title：Circulation research

authors： Tseng H,Peterson TE,Berk BC

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors (GPCRs), plays a central role in regulating basal tone and peripheral resistance. This occurs through inhibition of myosin light chain phosphatase, leading to incre...

journal_title：Circulation research

authors： Momotani K,Artamonov MV,Utepbergenov D,Derewenda U,Derewenda ZS,Somlyo AV

更新日期：2011-10-14 00:00:00

abstract：:-ATP-sensitive potassium (K(ATP)) channels were discovered in ventricular cells, but their roles in the heart remain mysterious. K(ATP) channels have also been found in numerous other tissues, including vascular smooth muscle. Two pore-forming subunits, Kir6.1 and Kir6.2, contribute to the diversity of K(ATP) channels...

journal_title：Circulation research

authors： Suzuki M,Li RA,Miki T,Uemura H,Sakamoto N,Ohmoto-Sekine Y,Tamagawa M,Ogura T,Seino S,Marbán E,Nakaya H

更新日期：2001-03-30 00:00:00

abstract：:The effects of endothelin on systemic and renal hemodynamics in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats were examined. Endothelin (500 ng i.v. +1,000 ng/hr per 300-g rat) elevated mean blood pressure by 13% (p less than 0.02) and decreased renal blood flow by 71% and glomerular filtrat...

journal_title：Circulation research

authors： Hirata Y,Matsuoka H,Kimura K,Fukui K,Hayakawa H,Suzuki E,Sugimoto T,Sugimoto T,Yanagisawa M,Masaki T

更新日期：1989-11-01 00:00:00

abstract：:Myocardial damage due to reperfusion of ischemic tissue is caused primarily by infiltrating neutrophils. Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent. This study examined the role of leukocyte beta1 integrin (alpha4) and i...

journal_title：Circulation research

authors： Bowden RA,Ding ZM,Donnachie EM,Petersen TK,Michael LH,Ballantyne CM,Burns AR

更新日期：2002-03-22 00:00:00

abstract：:To determine whether nifedipine, a calcium antagonist, protects ischemic myocardium, conscious dogs were subjected to coronary occlusion and given nifedipine by intravenous infusion beginning 30 minutes after the onset of ischemia and lasting for 24 hours while systemic arterial pressure, left atrial pressure, and car...

journal_title：Circulation research

authors： Henry PD,Shuchleib R,Borda LJ,Roberts R,Williamson JR,Sobel BE

更新日期：1978-09-01 00:00:00

abstract：RATIONALE:Lymphatic vasculature plays important roles in tissue fluid homeostasis maintenance and in the pathology of human diseases. Yet, the molecular mechanisms that control lymphatic vessel maturation remain largely unknown. OBJECTIVE:We analyzed the gene expression profiles of ex vivo isolated lymphatic endotheli...

journal_title：Circulation research

authors： Jurisic G,Maby-El Hajjami H,Karaman S,Ochsenbein AM,Alitalo A,Siddiqui SS,Ochoa Pereira C,Petrova TV,Detmar M

更新日期：2012-08-03 00:00:00

abstract：:The aim of the study was to investigate whether the adrenal renin-angiotensin system plays an independent role in the regulation of mineralocorticoid biosynthesis in the adrenal gland and to explore the mechanisms of this action. Twelve-week-old male Sprague-Dawley rats were studied: 22 rats were maintained on a regul...

journal_title：Circulation research

authors： Volpe M,Gigante B,Enea I,Porcellini A,Russo R,Lee MA,Magri P,Condorelli G,Savoia C,Lindpaintner K,Rubattu S

更新日期：1997-11-01 00:00:00

abstract：:We have recently characterized the promoter region of the rabbit embryonic smooth muscle myosin heavy chain (SMemb/NMHC-B) gene and identified the 15-bp sequence, designated SE1, located at -105 from the transcriptional start site as an important regulatory element for its transcriptional activity in a smooth muscle c...

journal_title：Circulation research

authors： Watanabe N,Kurabayashi M,Shimomura Y,Kawai-Kowase K,Hoshino Y,Manabe I,Watanabe M,Aikawa M,Kuro-o M,Suzuki T,Yazaki Y,Nagai R

更新日期：1999-07-23 00:00:00

abstract：:The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curved regions are proatherogenic, laminar flows in the straight parts are atheroprotective. Results from in vitro studies on c...

journal_title：Circulation research

authors： Shyy JY,Chien S

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:Obesity leads to increased ischemic heart disease (IHD) risk, but the risk is thought to be mediated through intermediate variables and may not be caused by increased weight per se. OBJECTIVE:To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressur...

journal_title：Circulation research

authors： Varbo A,Benn M,Smith GD,Timpson NJ,Tybjaerg-Hansen A,Nordestgaard BG

更新日期：2015-02-13 00:00:00

abstract：:Recent advances in cardiac physiology identify the integrin-linked kinase (ILK) as an essential molecule regulating cardiac growth, contractility, and repair. A key transducer of biochemical signals initiated at the plasma membrane by cell-matrix interactions, ILK now emerges as a crucial player in mechanotransduction...

journal_title：Circulation research

authors： Hannigan GE,Coles JG,Dedhar S

更新日期：2007-05-25 00:00:00

abstract：:This study was designed to determine if opioids were detectable in cerebrospinal fluid (CSF) and if these concentrations were altered by hemorrhagic hypotension. This study was further designed to determine the effects of topically administered opioids on pial arteriolar diameter during normotension and hypotension. C...

journal_title：Circulation research

authors： Armstead WM,Mirro R,Busija DW,Desiderio DM,Leffler CW

更新日期：1991-04-01 00:00:00

abstract：:Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by the enzyme heme ox...

journal_title：Circulation research

authors： Li A,Xi Q,Umstot ES,Bellner L,Schwartzman ML,Jaggar JH,Leffler CW

更新日期：2008-02-01 00:00:00

abstract：:Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen...

journal_title：Circulation research

authors： Quehenberger P,Exner M,Sunder-Plassmann R,Ruzicka K,Bieglmayer C,Endler G,Muellner C,Speiser W,Wagner O

更新日期：2002-04-05 00:00:00

abstract：:Rat lungs were inflated and incubated in either anionic or cationic ferritin, and alveolar and capillary basement membranes were examined by electron microscopy. Cationic ferritin bound to heparan sulfate proteoglycans on the external surface of the alveolar basement membrane, whereas cationic ferritin bound to the la...

journal_title：Circulation research

authors： Brody JS,Vaccaro CA,Hill NS,Rounds S

更新日期：1984-08-01 00:00:00

abstract：RATIONALE:The heart contains abundant interstitial and perivascular fibroblasts. Traditional views suggest that, under conditions of mechanical stress, cytokines, growth factors, and neurohumoral mediators stimulate fibroblast activation, inducing ECM (extracellular matrix) protein synthesis and promoting fibrosis and ...

journal_title：Circulation research

authors： Russo I,Cavalera M,Huang S,Su Y,Hanna A,Chen B,Shinde AV,Conway SJ,Graff J,Frangogiannis NG

更新日期：2019-04-12 00:00:00

abstract：:Platelet activation is markedly increased during coronary thrombolysis and limits the response to thrombolytic therapy. A possible mediator of platelet activation in this setting is thromboxane (TX) A2, a potent platelet agonist formed in greatly increased amounts during coronary thrombolysis in man. To address this h...

journal_title：Circulation research

authors： Fitzgerald DJ,Wright F,FitzGerald GA

更新日期：1989-07-01 00:00:00

abstract：:Rat myocardium expresses the 240- and 235-kD polypeptides antigenically related to alpha- and beta-subunits of brain calspectin (nonerythroid spectrin or fodrin), respectively. In the subcellular fractions of the myocardium, alpha-calspectin was found in the 600g, 10,000g, and 100,000g pellets, whereas beta-calspectin...

journal_title：Circulation research

authors： Yoshida K,Inui M,Harada K,Saido TC,Sorimachi Y,Ishihara T,Kawashima S,Sobue K

更新日期：1995-09-01 00:00:00

abstract：:We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin re...

journal_title：Circulation research

authors： Ayers CR,Katholi RE,Vaughan ED Jr,Carey RM,Kimbrough HM Jr,Yancey MR,Morton CL

更新日期：1977-03-01 00:00:00

abstract：RATIONALE:Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic ...

journal_title：Circulation research

authors： Li P,Zhu N,Yi B,Wang N,Chen M,You X,Zhao X,Solomides CC,Qin Y,Sun J

更新日期：2013-10-25 00:00:00

abstract：:We compared the effects of the newer inotropic drugs, pimobendan (UD-CG 115 BS) and milrinone (Win 47203), on the electrical, mechanical and biochemical activity of intact and detergent-skinned preparations of cardiac muscle. Both of these agents increased contractile force of guinea pig papillary muscle preparations ...

journal_title：Circulation research

authors： Fujino K,Sperelakis N,Solaro RJ

更新日期：1988-11-01 00:00:00

abstract：:Structure/function analysis shows that the carboxyl terminal (CT) domain of connexin43 (Cx43) is essential for the chemical regulation of cell-cell communication. Of particular interest is the region between amino acids 260 and 300. Structural preservation of this region is essential for acidification-induced uncoupli...

journal_title：Circulation research

authors： Calero G,Kanemitsu M,Taffet SM,Lau AF,Delmar M

更新日期：1998-05-18 00:00:00

abstract：RATIONALE:Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endo...

journal_title：Circulation research

authors： Sen S,Roy S,Bandyopadhyay G,Scott B,Xiao D,Ramadoss S,Mahata SK,Chaudhuri G

更新日期：2016-08-19 00:00:00

abstract：:Proliferation of vascular smooth muscle cells (VSMC) is a primary cause of vascular disorders and is associated with major alterations in Ca2+ handling supported by loss of the sarco/endoplasmic reticulum calcium ATPase, SERCA2a. To determine the importance of SERCA2a in neointima formation, we have prevented loss of ...

journal_title：Circulation research

authors： Lipskaia L,del Monte F,Capiod T,Yacoubi S,Hadri L,Hours M,Hajjar RJ,Lompré AM

更新日期：2005-09-02 00:00:00

abstract：:The influence that the pressure-sensitive receptors in the cardiovascular system have on renal nerve activity and on heart rate was compared in normotensive rats (NTR) and spontaneously hypertensive rats (SHR). The cardiovascular receptors were stimulated by raising the blood pressure (BP) with intravenous phenylephri...

journal_title：Circulation research

authors： Coote JH,Sato Y

更新日期：1977-06-01 00:00:00

abstract：:The extracellular and intracellular potassium (K+) activities of isolated superfused rabbit atrial muscle were measured using K+-sensitive liquid ion exchanger microelectrodes. When the pH of the bathing medium was decreased from 7.5 to 6.8, intracellular K+ activity fell and extracellular K+ activity rose from a mean...

journal_title：Circulation research

authors： Skinner RB Jr,Kunze DL

更新日期：1976-11-01 00:00:00

abstract：:Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy. Myocytes isolated from the midmyocardium of 13 dogs with heart failure induced by 3 to 4 wee...

journal_title：Circulation research

authors： Kääb S,Nuss HB,Chiamvimonvat N,O'Rourke B,Pak PH,Kass DA,Marban E,Tomaselli GF

更新日期：1996-02-01 00:00:00