Combined intercostal and diaphragm pacing to provide artificial ventilation in patients with tetraplegia.

Abstract:

OBJECTIVE:To evaluate the usefulness of combined intercostal and diaphragm pacing to maintain independence from mechanical ventilation. DESIGN:A prospective trial. SETTING:Clinical research center at a large tertiary hospital. PARTICIPANTS:Four ventilator-dependent subjects with spinal cord injury with only unilateral phrenic nerve function. INTERVENTION:During an initial surgical procedure, a multipolar epidural disk electrode was positioned on the ventral surface of the upper-thoracic spinal cord via a hemilaminectomy to activate the inspiratory intercostal muscles. A phrenic nerve electrode was implanted unilaterally via the thoracic approach. MAIN OUTCOME MEASURES:Inspired volume production and duration that subjects could be comfortably maintained when off mechanical ventilatory support. RESULTS:Initial maximum inspired volumes from combined intercostal and diaphragm stimulation ranged between .23 and .93L and significantly increased over the course of reconditioning period to between 0.55 and 1.31L; subjects could be maintained off mechanical ventilation between 16 and 24 hours a day. CONCLUSIONS:Combined intercostal and unilateral diaphragm pacing may be a useful therapeutic modality capable of maintaining long-term ventilatory support in patients with only unilateral phrenic nerve function.

journal_name

Arch Phys Med Rehabil

authors

DiMarco AF,Takaoka Y,Kowalski KE

doi

10.1016/j.apmr.2004.11.027

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1200-7

issue

6

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(05)00077-8

journal_volume

86

pub_type

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