Radial leaves of the maize mutant ragged seedling2 retain dorsiventral anatomy.


:ragged seedling2 (rgd2) is a novel, recessive mutation affecting lateral organ development in maize. The mutant phenotype of homozygous rgd2-R leaves is variable. Mild leaf phenotypes have a reduced midrib and may be moderately narrow and furcated; severe Rgd2-R(-) leaves are filamentous or even radial. Despite their radial morphology, severe Rgd2-R(-) mutant leaves develop distinct adaxial and abaxial anatomical features. Although Rgd2-R(-) mutants exhibit no reduction in adaxial or abaxial cell types, areas of epidermal cell swapping may occur that are associated with misaligned vascular bundles and outgrowths of ectopic margins. Scanning electron microscopy of young primordia and analyses of leaf developmental-marker gene expression in mutant apices reveal that RGD2 functions during recruitment of leaf founder cells and during expansive growth of leaf primordia. Overall, these phenotypes suggest that development is uncoordinated in Rgd2-R(-) mutant leaves, so that leaf components and tissues may develop quasi-independently. Models whereby RGD2 is required for developmental signaling during the initiation, anatomical patterning, and lateral expansion of maize leaves are discussed.


Dev Biol


Developmental biology


Henderson DC,Muehlbauer GJ,Scanlon MJ




Has Abstract


2005-06-15 00:00:00














  • Immunolocalization of basement membrane components and beta 1 integrin in the chick wing bud identifies specialized properties of the apical ectodermal ridge.

    abstract::To examine whether the extracellular matrix (ECM) plays a role in mediating interactions between the apical ectodermal ridge (AER) and the subjacent mesoderm in the chick wing bud, we used immunohistochemistry to locate the following tissue components during wing morphogenesis: types I and IV collagens, fibronectin, t...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Critchlow MA,Hinchliffe JR

    更新日期:1994-05-01 00:00:00

  • Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing.

    abstract::Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: O'Keefe DD,Prober DA,Moyle PS,Rickoll WL,Edgar BA

    更新日期:2007-11-01 00:00:00

  • A dual epimorphic and compensatory mode of heart regeneration in zebrafish.

    abstract::Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohis...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sallin P,de Preux Charles AS,Duruz V,Pfefferli C,Jaźwińska A

    更新日期:2015-03-01 00:00:00

  • Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation.

    abstract::During endochondral bone formation, vascular invasion initiates the replacement of avascular cartilage by bone. We demonstrate herein that the cartilage-specific overexpression of VEGF-A(164) in mice results in the hypervascularization of soft connective tissues away from cartilage. Unexpectedly, perichondrial tissue ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Takimoto A,Nishizaki Y,Hiraki Y,Shukunami C

    更新日期:2009-08-15 00:00:00

  • Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.

    abstract::The transcription factor Pax6 plays a pivotal role in eye development, as eye morphogenesis is arrested at a primitive optic vesicle stage in homozygous Pax6 mutant mouse embryos. The arrested optic vesicle development has led to the assumption that cellular differentiation programs are unable to initiate. Contrary to...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Philips GT,Stair CN,Young Lee H,Wroblewski E,Berberoglu MA,Brown NL,Mastick GS

    更新日期:2005-03-15 00:00:00

  • Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms.

    abstract::During early vertebrate development, members of the transforming growth factor beta (TGFbeta) family play important roles in a variety of processes, including germ layer specification, patterning, cell differentiation, migration, and organogenesis. The activities of TGFbetas need to be tightly controlled to ensure the...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Chang C,Eggen BJ,Weinstein DC,Brivanlou AH

    更新日期:2003-03-01 00:00:00

  • Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.

    abstract::Epigenetic gene control is involved in mechanisms of development. Little is known about the cooperation of nuclear and chromatin events in programmed differentiation from mouse embryonic stem cells (ESC). To address this, Oct3/4-positive ESC and differentiated progenies, Sox1-positive neural precursor cells (NPC) and ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Aoto T,Saitoh N,Ichimura T,Niwa H,Nakao M

    更新日期:2006-10-15 00:00:00

  • Auxology: when auxin meets plant evo-devo.

    abstract::Auxin is implicated throughout plant growth and development. Although the effects of this plant hormone have been recognized for more than a century, it is only in the past two decades that light has been shed on the molecular mechanisms that regulate auxin homeostasis, signaling, transport, crosstalk with other hormo...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Finet C,Jaillais Y

    更新日期:2012-09-01 00:00:00

  • Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.

    abstract::Wnt-4, a member of the Wnt family of secreted signaling molecules, is essential for nephrogenesis, but its expression in the presumptive medulla suggests additional developmental roles in kidney organogenesis. We demonstrate here that Wnt-4 signaling plays also a role in the determination of the fate of smooth muscle ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Itäranta P,Chi L,Seppänen T,Niku M,Tuukkanen J,Peltoketo H,Vainio S

    更新日期:2006-05-15 00:00:00

  • WNT5A-Ca2+-CaN-NFAT signalling plays a permissive role during cartilage differentiation in embryonic chick digit development.

    abstract::During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Farrera-Hernández A,Marín-Llera JC,Chimal-Monroy J

    更新日期:2021-01-01 00:00:00

  • Development of the central nervous system of the larva of the ascidian, Ciona intestinalis L. II. Neural plate morphogenesis and cell lineages during neurulation.

    abstract::We describe the lineage and morphogenesis of neural plate cells in the ascidian, Ciona intestinalis, from reconstructed cell maps of embryos at 12-min intervals during and after neurulation, between 31 and 61% of embryonic development. Neurulation commences in a posterior to anterior wave following in the wake of the ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Nicol D,Meinertzhagen IA

    更新日期:1988-12-01 00:00:00

  • Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.

    abstract::The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ozil JP,Banrezes B,Tóth S,Pan H,Schultz RM

    更新日期:2006-12-15 00:00:00

  • Confocal and video imaging of cytoskeleton dynamics in the leech zygote.

    abstract::Ooplasmic segregation in the late interphase zygote of the leech Theromyzon trizonare is accomplished by reorganization of an ectoplasmic cytoskeleton formed by polar rings and meridional bands. The dynamic properties of this cytoskeleton were explored by time-lapse confocal and video microscopy. Cytoskeleton assembly...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Fernández J,Toro J,Ubilla A

    更新日期:2004-07-01 00:00:00

  • WNT signaling in the control of hair growth and structure.

    abstract::Characterization of the molecular pathways controlling differentiation and proliferation in mammalian hair follicles is central to our understanding of the regulation of normal hair growth, the basis of hereditary hair loss diseases, and the origin of follicle-based tumors. We demonstrate that the proto-oncogene Wnt3,...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Millar SE,Willert K,Salinas PC,Roelink H,Nusse R,Sussman DJ,Barsh GS

    更新日期:1999-03-01 00:00:00

  • Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.

    abstract::Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lap...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Antonica F,Orietti LC,Mort RL,Zernicka-Goetz M

    更新日期:2019-06-15 00:00:00

  • Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum.

    abstract::Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Anjard C,Zeng C,Loomis WF,Nellen W

    更新日期:1998-01-15 00:00:00

  • Maturation of Xenopus oocytes is not accompanied by electrode-detectable calcium changes.

    abstract::Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Robinson KR

    更新日期:1985-06-01 00:00:00

  • Integrin signaling regulates blastocyst adhesion to fibronectin at implantation: intracellular calcium transients and vesicle trafficking in primary trophoblast cells.

    abstract::Accumulating evidence indicates that the endometrial extracellular matrix (ECM) modulates trophoblast adhesion during mouse blastocyst implantation. In previous studies of adhesion-competent mouse blastocysts, we have demonstrated that integrin-mediated fibronectin (FN)-binding activity on the apical surface of tropho...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wang J,Mayernik L,Armant DR

    更新日期:2002-05-15 00:00:00

  • Making sense of Dlx1 antisense RNA.

    abstract::Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

    更新日期:2013-04-15 00:00:00

  • Perturbation of cranial neural crest migration by the HNK-1 antibody.

    abstract::The HNK-1 antibody recognizes a carbohydrate moiety that is shared by a family of cell adhesion molecules and is also present on the surface of migrating neural crest cells. Here, the effects of the HNK-1 antibody on neural crest cells were examined in vitro and in vivo. When the HNK-1 antibody was added to neural tub...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bronner-Fraser M

    更新日期:1987-10-01 00:00:00

  • Redundancy and evolution of GATA factor requirements in development of the myocardium.

    abstract::The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Peterkin T,Gibson A,Patient R

    更新日期:2007-11-15 00:00:00

  • Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.

    abstract::Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse between organisms, the RNA binding protein Nanos is consistently required in the germ line in all species tested. How Nanos is selectively expressed in the germ line...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Oulhen N,Swartz SZ,Wang L,Wikramanayake A,Wessel GM

    更新日期:2019-08-01 00:00:00

  • Correct cell-type-specific expression of a fusion gene injected into sea urchin eggs.

    abstract::A fusion gene construct containing the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of CyIIIa actin gene regulatory sequences was injected into unfertilized eggs of the urchin Strongylocentrotus purpuratus, and early pluteus stage embryos that developed from these eggs were fixed and sectio...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Hough-Evans BR,Franks RR,Cameron RA,Britten RJ,Davidson EH

    更新日期:1987-06-01 00:00:00

  • Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development.

    abstract::Distinct groups of dopaminergic neurons develop at defined anatomical sites in the brain to modulate function of a large diversity of local and far-ranging circuits. However, the molecular identity as judged from transcription factor expression has not been determined for all dopaminergic groups. Here, we analyze regi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Filippi A,Jainok C,Driever W

    更新日期:2012-09-01 00:00:00

  • Changing distributions of extracellular matrix components during early wing morphogenesis in Drosophila.

    abstract::A new monoclonal antibody, specific to an epitope in the carboxyl terminus of the Drosophila collagen IV molecule (basement membrane collagen) was identified. The distributions of collagen IV, laminin, and an additional extracellular molecule, the 2G2 antigen (2G2-Ag), were followed immunocytochemically during early w...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Murray MA,Fessler LI,Palka J

    更新日期:1995-03-01 00:00:00

  • Cyclin A associates with the fusome during germline cyst formation in the Drosophila ovary.

    abstract::Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lilly MA,de Cuevas M,Spradling AC

    更新日期:2000-02-01 00:00:00

  • Regulation of Src kinase activity during Xenopus oocyte maturation.

    abstract::Expression of constitutively active Src protein tyrosine kinase in Xenopus oocytes has been shown to accelerate oocyte maturation suggesting that Src may be involved in meiotic progression. However, meiotic regulation of endogenous Src kinase in oocytes has not been investigated in detail. To address this problem, we ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tokmakov A,Iwasaki T,Itakura S,Sato K,Shirouzu M,Fukami Y,Yokoyama S

    更新日期:2005-02-15 00:00:00

  • The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube.

    abstract::Neural crest cells migrate along two pathways in the trunk: the ventral path, between the neural tube and somite, and the dorsolateral path, between the somite and overlying ectoderm. In avian embryos, ventral migration precedes dorsolateral migration by nearly 24 h, and the onset of dorsolateral migration coincides w...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Reedy MV,Faraco CD,Erickson CA

    更新日期:1998-08-15 00:00:00

  • Epithelial control of periotic mesenchyme chondrogenesis.

    abstract::Morphogenesis of the cartilaginous otic capsule is directed by interactions between the epithelial anlage of the membranous labyrinth (otocyst) and its associated periotic mesenchyme. Utilizing a developmental series of high-density (micromass) cultures of periotic mesenchyme to model capsule chondrogenesis, we have s...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Frenz DA,Van De Water TR

    更新日期:1991-03-01 00:00:00

  • Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus.

    abstract::While Wnt signaling is known to be involved in early steps of neural crest development, the mechanism remains unclear. Because Wnt signaling is able to posteriorize anterior neural tissues, neural crest induction by Wnts has been proposed to be an indirect consequence of posteriorization of neural tissues rather than ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wu J,Yang J,Klein PS

    更新日期:2005-03-01 00:00:00