Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients.

abstract：BACKGROUND:Anti-TNF agents are now widely used in Crohn's disease (CD), and in ulcerative colitis (UC). AIM:To review the safety profile of anti-TNF agents in all patients treated with infliximab in Edinburgh from 1999 to 2007. METHODS:Complete data were available on 202/207 patients comprising 157 CD, 42 UC and thre...

journal_title：Alimentary pharmacology & therapeutics

authors： Lees CW,Ali AI,Thompson AI,Ho GT,Forsythe RO,Marquez L,Cochrane CJ,Aitken S,Fennell J,Rogers P,Shand AG,Penman ID,Palmer KR,Wilson DC,Arnott ID,Satsangi J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Cannabinoid (CB) receptors have been located in brain areas involved in the triggering of TLESRs as well as in the nodose ganglion from which vagal afferents emanate. The distribution of CB(1) receptors has been investigated in the human gastrointestinal mucosa, as expression of inflammatory process. AIM:To...

journal_title：Alimentary pharmacology & therapeutics

authors： Calabrese C,Spisni E,Liguori G,Lazzarini G,Valerii MC,Strillacci A,Gionchetti P,Pagotto U,Campieri M,Rizzello F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The presence of antibodies towards infliximab (ATI) is associated with lower infliximab (IFX) trough concentrations and loss of response. IFX treatment intensification is effective for restoring response in most, but not all patients with Crohn's disease (CD). AIM:To compare outcome, pharmacokinetics and im...

journal_title：Alimentary pharmacology & therapeutics

authors： Dreesen E,Van Stappen T,Ballet V,Peeters M,Compernolle G,Tops S,Van Steen K,Van Assche G,Ferrante M,Vermeire S,Gils A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:While empiric acid-suppressive therapy for uninvestigated dyspepsia patients with symptoms of epigastric pain or burning is standard practice, it is unknown whether an early response to therapy predicts outcome. AIM:To evaluate whether a 1-w acid suppression trial is effective for predicting 8-w response in...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zanten SV,Flook N,Talley NJ,Vakil N,Lauritsen K,Bolling-Sternevald E,Persson T,Björck E,Svedberg LE,STARS II Study Group.

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Laparoscopic cholecystectomy (LC) is recommended for patients with choledocholithiasis after ERCP with sphincterotomy (ES) and stone extraction. AIM:We designed a decision model to address whether ES alone versus ES followed by LC (ES + LC) is the optimal treatment in high-risk patients with choledocholithi...

journal_title：Alimentary pharmacology & therapeutics

authors： Siddiqui AA,Mitroo P,Kowalski T,Loren D

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Few outcome studies directly compare Helicobacter pylori eradication therapy with maintenance H2-antagonist therapy in duodenal ulcer disease. AIM:To examine prospectively the efficacy of H. pylori eradication therapy with ranitidine maintenance therapy over 1 year in patients with confirmed chronic duodena...

journal_title：Alimentary pharmacology & therapeutics

authors： Prach AT,Malek M,Tavakoli M,Hopwood D,Senior BW,Murray FE

更新日期：1998-09-01 00:00:00

abstract：:Despite the fact that non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs in medicine today, 2-10% of patients must discontinue their use primarily due to gastrointestinal (GI) side-effects. While the development of non-aspirin NSAIDs (NA-NSAIDs) has significantly reduced GI side-effect...

journal_title：Alimentary pharmacology & therapeutics

authors： Butt JH,Barthel JS,Hosokawa MC,Moore RA

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

journal_title：Alimentary pharmacology & therapeutics

authors： Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

更新日期：1998-10-01 00:00:00

abstract：:Methotrexate has a place in the treatment of an increasing number of diseases. Its emerging role in the treatment of primary biliary cirrhosis and inflammatory bowel disease still requires further evaluation. Its toxicity profile is wide and is affected by a variety of factors. Hepatotoxicity from long-term use in pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Tang H,Neuberger J

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Approximately one third of patients with acute severe ulcerative colitis (ASUC) fail response to steroids. Ciclosporin and anti-TNFα are proven second-line therapies, but evidence of their efficacy has come mainly from tertiary centres and/or selective clinical trial recruitment. AIM:To assess ASUC outcomes...

journal_title：Alimentary pharmacology & therapeutics

authors： Lynch RW,Lowe D,Protheroe A,Driscoll R,Rhodes JM,Arnott ID

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a calcineurin inhibitor commonly used for prophylaxis of rejection in renal and liver transplantation. There are limited but favourable data regarding its possible use in patients with inflammatory bowel disease (IBD). AIMS:To evaluate the efficacy and safety of tacrolimus in patients with IBD...

journal_title：Alimentary pharmacology & therapeutics

authors： Rodríguez-Lago I,Castro-Poceiro J,Fernández-Clotet A,Mesonero F,López-Sanromán A,López-García A,Márquez L,Clos-Parals A,Cañete F,Vicuña M,Nantes Ó,Merino O,Matallana V,Gordillo J,Elorza A,Vicente R,Casanova MJ,Ferreiro-

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Triple therapy based upon omeprazole, amoxycillin and clarithromycin for 7 days is the reference treatment used in France for the eradication of Helicobacter pylori. However, optimal dosages of omeprazole and clarithromycin have not been determined. AIMS:To compare four eradication regimens using this treat...

journal_title：Alimentary pharmacology & therapeutics

authors： Bigard MA,Delchier JC,Riachi G,Thibault P,Barthelemy P

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Cisapride has been reported to improve symptoms in patients with constipation-predominant irritable bowel syndrome. AIM:To compare the effects of a 24-h oral dose regimen of cisapride on interdigestive and post-prandial small bowel motor activity in irritable bowel syndrome patients with predominant constip...

journal_title：Alimentary pharmacology & therapeutics

authors： Evans PR,Bak YT,Kellow JE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:A high proportion of patients with inflammatory bowel disease (IBD) do not achieve clinical remission with the current therapies including mesalazine (mesalamine), immunossupresants (IMS) and antibodies against tumour necrosis factor (anti-TNF). Moreover, IMS and anti-TNF involve a nonnegligible risk for inf...

journal_title：Alimentary pharmacology & therapeutics

authors： Lobatón T,Vermeire S,Van Assche G,Rutgeerts P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well recognised. However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of se...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Guzman-Perez R,Gainer V,Cai T,Churchill S,Kohane I,Plenge RM,Murphy S

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Comparative long-term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) for prevention of disease progression to hepatocellular carcinoma (HCC) among high-risk patients with chronic hepatitis B (CHB)-related compensated cirrhosis is controversial. AIMS:To compare the long-term efficacy of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu TH,Yueh-Hsia Chiu S,Tseng PL,Chen CH,Lu SN,Wang JH,Hung CH,Kee KM,Lin MT,Chang KC,Lin MC,Chien RN

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Surgical resection of Crohn's disease is followed by early recurrence in a high percentage of patients. Mesalazine has been shown to be effective in the prevention of post-operative recurrence, but some 50% of patients under treatment recur at 3 years of follow-up. AIM:To establish whether the mucosal conce...

journal_title：Alimentary pharmacology & therapeutics

authors： Frieri G,Pimpo MT,Andreoli A,Annese V,Comberlato M,Corrao G,Palumbo G,Sturniolo GC,Tonelli F,Caprilli R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

journal_title：Alimentary pharmacology & therapeutics

authors： Mönkemüller KE,Hirschowitz BI

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The incidence of Barrett's oesophageal adenocarcinoma is increasing more rapidly than any other malignancy in industrialized countries. Cyclo-oxygenase-2 appears to play an important role in gastrointestinal carcinogenesis. Previous studies on cyclo-oxygenase-2 expression in Barrett's oesophageal carcinogene...

journal_title：Alimentary pharmacology & therapeutics

authors： Cheong E,Igali L,Harvey I,Mole M,Lund E,Johnson IT,Rhodes M

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Response to proton pump inhibitor (PPI) treatment in dyspepsia is unpredictable. AIM:To identify symptoms associated with response to esomeprazole in order to target patients for empirical treatment. METHODS:Eight hundred and five uninvestigated, primary care patients with upper GI symptoms that were consi...

journal_title：Alimentary pharmacology & therapeutics

authors： Meineche-Schmidt V,Christensen E,Bytzer P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:No definitive method for quantitative evaluation of hepatic function has as yet been established. AIM:To investigate whether the (13)C-phenylalanine breath test would be useful for the evaluation of hepatic function in patients with liver cirrhosis and acute hepatitis. METHODS:L-[1-(13)C]-phenylalanine was...

journal_title：Alimentary pharmacology & therapeutics

authors： Koeda N,Iwai M,Kato A,Suzuki K

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Adalimumab is effective in inducing remission in patients with active Crohn's disease who had secondary failure to infliximab therapy. AIM:To evaluate the efficacy and safety of adalimumab maintenance therapy in Crohn's disease patients who previously responded to infliximab and then lost response or became...

journal_title：Alimentary pharmacology & therapeutics

authors： Peyrin-Biroulet L,Laclotte C,Bigard MA

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Bacteria have been implicated in the pathogenesis of inflammatory bowel disease. Helicobacter species have been shown to cause colitis in animal models and have been identified in human diarrhoeal illness and Crohn's disease. AIM:To determine whether Helicobacter species are present in human inflammatory bo...

journal_title：Alimentary pharmacology & therapeutics

authors： Bell SJ,Chisholm SA,Owen RJ,Borriello SP,Kamm MA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Uninvestigated dyspepsia is common in family practice. The prevalence of clinically significant upper gastrointestinal findings (CSFs) in adult uninvestigated dyspepsia patients, and their predictability based on history, is unknown. METHODS:Prompt endoscopy was performed within 10 days of referral, in 1040...

journal_title：Alimentary pharmacology & therapeutics

authors： Thomson AB,Barkun AN,Armstrong D,Chiba N,White RJ,Daniels S,Escobedo S,Chakraborty B,Sinclair P,Van Zanten SJ

更新日期：2003-06-15 00:00:00

abstract：BACKGROUND:Endothelins have been implicated in gastric mucosal damage in a variety of animal models. Exogenous ET-1 and ET-3 are causally associated with experimental gastric ulcers. Furthermore, clinical reports also show elevated plasma and gastric mucosal endothelin-1 levels in patients suffering from peptic ulcers....

journal_title：Alimentary pharmacology & therapeutics

authors： Padol I,Huang JQ,Hunt RH

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor (TNF)-antagonists have an established role in the treatment of inflammatory bowel diseases (IBDs), however, subtherapeutic drug levels and the formation of anti-drug antibodies (ADAs) may decrease their efficacy. AIM:The evidence supporting the use of therapeutic drug monitoring (TDM)...

journal_title：Alimentary pharmacology & therapeutics

authors： Khanna R,Sattin BD,Afif W,Benchimol EI,Bernard EJ,Bitton A,Bressler B,Fedorak RN,Ghosh S,Greenberg GR,Marshall JK,Panaccione R,Seidman EG,Silverberg MS,Steinhart AH,Sy R,Van Assche G,Walters TD,Sandborn WJ,Feagan BG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Unable to resolve a medical problem, gastroenterologists occasionally choose an ineffectual intervention instead. The elusive path to effectual management becomes substituted with an ineffectual but readily available medical ritual. The term 'ritual' refers to the utilization of an ineffectual intervention w...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The gamma-aminobutyric acid receptor type B agonist, baclofen, inhibits transient lower oesophageal sphincter relaxations by influencing a vagal pathway. Although post-prandial proximal gastric function, which is vagally mediated, is important in the occurrence of transient lower oesophageal sphincter relaxa...

journal_title：Alimentary pharmacology & therapeutics

authors： Lee KJ,Vos R,Janssens J,Tack J

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM:To investigate trends ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lophaven SN,Lynge E,Burisch J

更新日期：2017-04-01 00:00:00

abstract：:Six asymptomatic, non-smoking men with endoscopically proven duodenal ulcer disease received single nocturnal doses of placebo, 40 mg famotidine and 300 mg ranitidine each for 1 week prior to serial measurement of pH, peptic activity and serum gastrin concentrations over 24 h and of acid output. The intragastric pH fl...

journal_title：Alimentary pharmacology & therapeutics

authors： Thomson AB,Pinchbeck BR,Kirdeikis J,Zuk L,Marriage B,Prat A

更新日期：1989-04-01 00:00:00