Abstract:
:From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 1, 3, 10, 11, and 12 showed inhibitory activities more potent (IC50, 13.8-26.1 microg/ml) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC50, 27.4 microg/ml).
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Awale S,Kawakami T,Tezuka Y,Ueda JY,Tanaka K,Kadota Sdoi
10.1248/cpb.53.710subject
Has Abstractpub_date
2005-06-01 00:00:00pages
710-3issue
6eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/53.710journal_volume
53pub_type
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