D-penicillamine and immune complex deposition.

abstract：BACKGROUND:Vascular damage is a key pathological process in systemic sclerosis (SSc) and accounts for significant disease-related morbidity. To determine the clinical burden of severe digital vasculopathy (SDV), we have reviewed hospital-based treatment for this important complication of SSc in a large single centre co...

journal_title：Annals of the rheumatic diseases

authors： Nihtyanova SI,Brough GM,Black CM,Denton CP

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea. METHODS:Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and ...

journal_title：Annals of the rheumatic diseases

authors： Lee YJ,Shin KS,Kang SW,Lee CK,Yoo B,Cha HS,Koh EM,Yoon SJ,Lee J

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term effects of induction therapy with adalimumab (ADA) plus methotrexate (MTX) in comparison with placebo (PBO) plus MTX in DMARD-naïve patients with active early rheumatoid arthritis (RA). METHODS:Patients with active early RA (disease duration of ≤12 months) were randomly assigned ...

journal_title：Annals of the rheumatic diseases

authors： Detert J,Bastian H,Listing J,Weiß A,Wassenberg S,Liebhaber A,Rockwitz K,Alten R,Krüger K,Rau R,Simon C,Gremmelsbacher E,Braun T,Marsmann B,Höhne-Zimmer V,Egerer K,Buttgereit F,Burmester GR

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms. OBJECTIVE:To investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the exp...

journal_title：Annals of the rheumatic diseases

authors： Yatabe T,Mochizuki S,Takizawa M,Chijiiwa M,Okada A,Kimura T,Fujita Y,Matsumoto H,Toyama Y,Okada Y

更新日期：2009-06-01 00:00:00

abstract：:Polyclonal anticardiolipin antibodies purified from pooled serum samples of patients with systemic lupus erythematosus were shown to have inhibitory effects on cultured normal rat brain astrocytes (RBA-1 cells). Anticardiolipin antibodies at concentrations from 50 to 200 micrograms/ml inhibited the [3H]thymidine incor...

journal_title：Annals of the rheumatic diseases

authors： Sun KH,Liu WT,Tsai CY,Liao TS,Lin WM,Yu CL

更新日期：1992-06-01 00:00:00

abstract：:The effect of the intra-articular injection of radioactive erbium 169 and yttrium 90 on the growth of the leg in rabbits has been studied. I colloid state these isotopes are used clinically for synovial ablation. These beta emitters slow down bone growth in proportion to the amount of radioactivity injected. If the jo...

journal_title：Annals of the rheumatic diseases

authors： Rebut-Bonneton C,Roucayrol JC,Delbarre F

更新日期：1975-12-01 00:00:00

abstract：:The recent approval of belimumab for the treatment of systemic lupus erythematosus (SLE) ended a decade in which there was mounting optimism about the prospect for developing biologically based therapies for SLE. During this same period, steady progress had been made in understanding and applying conventional therapie...

journal_title：Annals of the rheumatic diseases

authors： Wofsy D

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental arthritis in mouse knee joints. METHODS:To characterise IGF-1 nonresponsiveness during arthritis, we measured chondrocyte...

journal_title：Annals of the rheumatic diseases

authors： Verschure PJ,Joosten LA,Van de Loo FA,Van den Berg WB

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:To study the ability of technetium-99m hexamethyl propylene amineoxime (HMPAO) labelled lymphocyte scintigraphy to quantify synovial inflammation, and to analyse the kinetics of lymphocyte retention in the joints of patients with rheumatoid arthritis (RA). METHODS:After isolation of the lymphocytes, the cel...

journal_title：Annals of the rheumatic diseases

authors： Jorgensen C,Couret I,Bologna C,Rossi M,Sany J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:A recent study from our laboratory showed that induction of the multidrug resistance related drug efflux pump ABCG2 contributed to acquired resistance of human T cells to the disease modifying antirheumatic drug (DMARD) sulfasalazine (SSZ). OBJECTIVES:To investigate the duration of SSZ resistance and ABCG2 ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijden J,de Jong MC,Dijkmans BA,Lems WF,Oerlemans R,Kathmann I,Scheffer GL,Scheper RJ,Assaraf YG,Jansen G

更新日期：2004-02-01 00:00:00

abstract：:A previous infection of C3H mice with viable Mycoplasma pulmonis organisms protected them from arthritis induced by intravenous inoculation of these organisms, whether or not their initial arthritis had resolved at the time of challenge. Although spleen cells obtained from such animals conferred resistance to acute ar...

journal_title：Annals of the rheumatic diseases

authors： Taylor G,Taylor-Robinson D

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment of psoriatic arthritis (PsA). We evaluated upadacitinib in patients with PsA and prior inadequate response or intolerance to at least one biologic disease-modifying antirheumatic drug (DMARD). METHODS:In this 24-week randomised, pla...

journal_title：Annals of the rheumatic diseases

authors： Mease PJ,Lertratanakul A,Anderson JK,Papp K,Van den Bosch F,Tsuji S,Dokoupilova E,Keiserman M,Wang X,Zhong S,McCaskill RM,Zueger P,Pangan AL,Tillett W

更新日期：2020-12-03 00:00:00

abstract：:The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose...

journal_title：Annals of the rheumatic diseases

authors： Godfrey DG,Stimson WH,Watson J,Belch JF,Sturrock RD

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVES:Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether statin use was associated with an increased risk of dev...

journal_title：Annals of the rheumatic diseases

authors： de Jong HJ,Klungel OH,van Dijk L,Vandebriel RJ,Leufkens HG,van der Laan JW,Cohen Tervaert JW,van Loveren H

更新日期：2012-05-01 00:00:00

abstract：:Alefacept is a bioengineered fusion protein of soluble lymphocyte function antigen (LFA-3) with Fc fragments of IgG1. It is marketed in many countries for the treatment of moderate to severe psoriasis. This paper reviews the data supporting the use of alefacept in psoriasis and psoriatic arthritis. ...

journal_title：Annals of the rheumatic diseases

authors： Gottlieb AB

更新日期：2005-11-01 00:00:00

abstract：:Patients with Sjögren's syndrome alone (Ss), Sjögren's syndrome with rheumatoid arthritis (Ss-RA), and Sjögren's syndrome with Raynaud's phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patien...

journal_title：Annals of the rheumatic diseases

authors： Mann DL,Moutsopoulos HM

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibodies (ACPAs) are the hallmark of rheumatoid arthritis (RA). Protein citrullination is believed to drive autoantigen selection in RA. Nonetheless, several autoantigens in RA are targeted as native (unmodified) proteins. Here, the study of hnRNP A2/B1 (RA33) provides a framewor...

journal_title：Annals of the rheumatic diseases

authors： Konig MF,Giles JT,Nigrovic PA,Andrade F

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Osteoarthritis is the most frequent chronic joint disease causing pain and disability. Besides biomechanical mechanisms, the pathogenesis of osteoarthritis may involve inflammation, vascular alterations and dysregulation of lipid metabolism. As statins are able to modulate many of these processes, this study...

journal_title：Annals of the rheumatic diseases

authors： Clockaerts S,Van Osch GJ,Bastiaansen-Jenniskens YM,Verhaar JA,Van Glabbeek F,Van Meurs JB,Kerkhof HJ,Hofman A,Stricker BH,Bierma-Zeinstra SM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout r...

journal_title：Annals of the rheumatic diseases

authors： Matsuo H,Yamamoto K,Nakaoka H,Nakayama A,Sakiyama M,Chiba T,Takahashi A,Nakamura T,Nakashima H,Takada Y,Danjoh I,Shimizu S,Abe J,Kawamura Y,Terashige S,Ogata H,Tatsukawa S,Yin G,Okada R,Morita E,Naito M,Tokumasu

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the effect of infliximab on health related quality of life (HRQoL) and physical function in patients with active psoriatic arthritis (PsA) in the IMPACT 2 trial. METHODS:200 patients with PsA unresponsive to conventional treatment were randomised to intravenous infusions of infliximab 5 mg/kg or...

journal_title：Annals of the rheumatic diseases

authors： Kavanaugh A,Antoni C,Krueger GG,Yan S,Bala M,Dooley LT,Beutler A,Guzzo C,Gladman D

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To study the risk of a second malignant neoplasm (SMN) and mortality in patients with rheumatoid arthritis (RA) with a history of a primary cancer diagnosis and treated with biological disease-modifying antirheumatic drugs (bDMARD). METHODS:Among patients with RA (n=15 286) registered in the DANBIO Register ...

journal_title：Annals of the rheumatic diseases

authors： Dreyer L,Cordtz RL,Hansen IMJ,Kristensen LE,Hetland ML,Mellemkjaer L

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

journal_title：Annals of the rheumatic diseases

authors： Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To estimate the cost of illness in an incidence based cohort of patients with juvenile idiopathic arthritis. METHODS:Direct costs (healthcare and non-healthcare costs) and indirect costs (productivity loss due to sick leave and work disability) were measured in 215 JIA patients, assessed on an average of 17 ...

journal_title：Annals of the rheumatic diseases

authors： Minden K,Niewerth M,Listing J,Biedermann T,Schöntube M,Zink A

更新日期：2004-07-01 00:00:00

abstract：:A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in p...

journal_title：Annals of the rheumatic diseases

authors： Martin MF,Dieppe PA,Jones HE,Warren C,Whicher J,Kohn J

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVES:Assess golimumab's long-term efficacy/safety in psoriatic arthritis (PsA). METHODS:Adults with active PsA (≥3 swollen and tender joints, active psoriasis) were randomly assigned to subcutaneous placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks (q4wks) through wk20. All patients received golimumab ...

journal_title：Annals of the rheumatic diseases

authors： Kavanaugh A,McInnes IB,Mease P,Krueger GG,Gladman D,van der Heijde D,Zhou Y,Lu J,Leu JH,Goldstein N,Beutler A

更新日期：2014-09-01 00:00:00

abstract：:Mild iron deficiency induced by treatment with the iron chelator desferrioxamine reduced the incidence and severity of joint inflammation associated with adjuvant disease in rats but did not alter the local primary inflammatory response or the systemic sequelae. Both rats treated with desferrioxamine and control rats ...

journal_title：Annals of the rheumatic diseases

authors： Andrews FJ,Morris CJ,Kondratowicz G,Blake DR

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of a switch from oral methotrexate (MTX) to subcutaneous MTX (scMTX) or adding ciclosporin to oral MTX with a simultaneous reduction of the MTX dose, in case of adverse events (AE) or insufficient effect (IE) in rheumatoid arthritis (RA). METHODS:The tight control treatment arm of ...

journal_title：Annals of the rheumatic diseases

authors： Bakker MF,Jacobs JW,Welsing PM,van der Werf JH,Linn-Rasker SP,van der Veen MJ,Lafeber FP,Bijlsma JW,Utrecht Arthritis Cohort Study Group.

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular ...

journal_title：Annals of the rheumatic diseases

authors： Urano W,Taniguchi A,Anzai N,Inoue E,Kanai Y,Yamanaka M,Endou H,Kamatani N,Yamanaka H

更新日期：2010-06-01 00:00:00

abstract：:Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Taylor L,Baker RD,Jayson MI

更新日期：1988-07-01 00:00:00