Abstract：
BACKGROUND:Age-adjusted morbidity and mortality rates from coronary heart disease (CHD) are higher in men than in women. Androgens are suspected to be responsible for the male disadvantage. The genomic effect of androgens is mediated by the androgen receptor (AR), which has a polymorphic CAG repeat in exon 1. The number of repeats is inversely related to the transcriptional activity of the AR on target genes. METHODS:We investigated the association of this CAG repeat polymorphism with CHD and myocardial infarction (MI) in 2 independent case-control studies involving 544 Caucasian men. RESULTS:The number of CAG repeats in the AR gene correlated significantly with HDL-cholesterol (HDL-C) in controls (r = 0.21; P = 0.015). This effect was independent of triglycerides, body mass index, alcohol intake, smoking, and age in a multiple regression model (R(2) = 50%). Despite decreased HDL-C, lower CAG repeat numbers were not associated with increased risk for CHD (odds ratio = 0.82; 95% confidence interval, 0.50-1.36; P = 0.44) or MI in carriers of AR genes with lower CAG repeat numbers (odds ratio = 0.72; 95% confidence interval, 0.37-1.39; P = 0.33). CONCLUSIONS:Shorter, more androgenic AR alleles with fewer CAG repeats are associated with lower HDL-C, but not with an increased risk for CHD or MI, which argues against a detrimental androgen effect on cardiovascular risk under physiologic conditions.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Hersberger M,Muntwyler J,Funke H,Marti-Jaun J,Schulte H,Assmann G,Lüscher TF,von Eckardstein Adoi
10.1373/clinchem.2005.049262subject
Has Abstractpub_date
2005-07-01 00:00:00pages
1110-5issue
7eissn
0009-9147issn
1530-8561pii
clinchem.2005.049262journal_volume
51pub_type
杂志文章,多中心研究abstract：:The Dutch Foundation for Quality Assessment in Clinical Chemistry (SKZL) is the professional organization that conducts external quality-assessment schemes in The Netherlands. However, such schemes in fact assess the performance of the internal quality-control systems of the participating laboratories. In this paper w...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
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abstract：BACKGROUND:In malignancy, gene mutations frequently occur in tumor suppressor genes such as p53 and are sporadically located. We describe a homogeneous method for amplification and mutation scanning, and apply the method to the p53 gene. METHODS:Using a series of overlapping fluorescein-labeled oligonucleotides comple...
journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:Distinguishing adenocarcinoma and squamous cell carcinoma subtypes of non-small cell lung cancers is critical to patient care. Preoperative minimally-invasive biopsy techniques, such as fine needle aspiration (FNA), are increasingly used for lung cancer diagnosis and subtyping. Yet, histologic distinction of...
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pub_type： 杂志文章
doi：10.1093/clinchem/hvaa207
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
pub_type： 杂志文章,评审
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
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pub_type： 杂志文章,meta分析
doi：10.1373/clinchem.2012.190322
更新日期：2012-11-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：10.1373/clinchem.2008.108845
更新日期：2008-12-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
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doi：10.1373/clinchem.2012.193060
更新日期：2013-01-01 00:00:00
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doi：10.1373/clinchem.2008.122572
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doi：
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journal_title：Clinical chemistry
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doi：
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doi：
更新日期：1998-06-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1998-07-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1985-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
更新日期：1991-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1979-07-01 00:00:00
