Evaluation of chemosensitivity testing with highly purified tumor cells in 435 patients with gastric carcinoma using an MTT assay.

abstract：BACKGROUND:Recently, it has become obvious that the HMGB1 protein can act as a proinflammatory and proangiogenic mediator when actively secreted by macrophages or passively released from necrotic cells playing an important role in the pathogenesis of several diseases including cancer. MATERIALS AND METHODS:The absolut...

journal_title：Anticancer research

authors： Winter N,Meyer A,Richter A,Krisponeit D,Bullerdiek J

更新日期：2009-12-01 00:00:00

abstract：:Bisphosphonates are strong inhibitors of osteoclastic bone resorption in both benign and malignant bone diseases. The nitrogen-containing bisphosphonates (N-BPs) have strong cytotoxicity via inhibition of protein prenylation in the mevalonate pathway, and also demonstrate direct cytostatic and proapoptotic effects on ...

journal_title：Anticancer research

authors： Tanaka T,Kawashima H,Ohnishi K,Matsumura K,Yoshimura R,Matsuyama M,Kuratsukuri K,Nakatani T

更新日期：2009-04-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Certain viruses, notably human papillomavirus (HPV), cytomegalovirus (CMV), herpes simplex virus (HSV) and Epstein-Barr virus (EBV), are known to produce tumors in animals and cell transformation in vitro and they have been implicated in the pathogenesis of human cancers. All these viruses are also known to ...

journal_title：Anticancer research

authors： Chang F,Syrjänen S,Shen Q,Cintorino M,Santopietro R,Tosi P,Syrjänen K

更新日期：2000-09-01 00:00:00

abstract：AIM:The purpose of this prospective evaluation was to assess the late neurologic adverse events and Karnofsky performance status (KPS) in patients with at least two brain metastases from non-small cell lung cancer treated with whole-brain radiotherapy (WBRT) with or without sequential systemic chemotherapy. PATIENTS A...

journal_title：Anticancer research

authors： Nieder C,Astner ST,Grosu AL,Molls M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND/AIM:Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this ...

journal_title：Anticancer research

authors： Ploskonos MV,Syatkin SP,Neborak EV,Hilal A,Sungrapova KY,Sokuyev RI,Blagonravov ML,Korshunova AY,Terentyev AA

更新日期：2020-03-01 00:00:00

abstract：:Mammography, and in special cases MRT, allow the detection of DCIS and microcarcinomas. Breast preserving surgery needs intraoperative care for tumor free margins. Decision making under favourable and unfavourable conditions is discussed. Tumor grading is important with respect to locoregional recurrences. Improvement...

journal_title：Anticancer research

authors： Schauer A,Marx D,Schauer M,Binder C,Kuhn W,Meden H

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have attracted great interest in cancer therapy since the discovery of their tumor tropism. This study was performed to investigate the effects of TNF-related apoptosis-inducing ligand (TRAIL)-engineered MSCs on hepatocellular carcinoma (HCC) cells (HepG2) under different cultur...

journal_title：Anticancer research

authors： Sun XY,Nong J,Qin K,Lu H,Moniri MR,Dai LJ,Warnock GL

更新日期：2011-11-01 00:00:00

abstract：:UGP (Urinary gonadotropin peptide) also know as urinary gonadotropin fragment (UGF) or the beta-core of hCG (c beta hCG), was identified as a peptide with a molecular weight of 10.5 kD, having the same amino acid sequence as the core section of the beta-subunit of human chorionic gonadotropin. UGP has been found in no...

journal_title：Anticancer research

authors： el-Ahmady O,Halim AB,Gad M,Walker R

更新日期：1996-07-01 00:00:00

abstract：UNLABELLED:Adenomatous polyps are precursor lesions for colorectal carcinoma. The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas. The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investig...

journal_title：Anticancer research

authors： Giuliani A,Caporale A,Corona M,Ricciardulli T,Di Bari M,Demoro M,Scarpini M,Angelico F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIM:Neuroendocrine neoplasms (NEN) of the female genital tract account for 2% of gynecological cancers. The aim of this study was to share our experience of 11 primary neuroendocrine neoplasms of the ovary. PATIENTS AND METHODS:All patients who presented and/or were treated at our Institution with histologi...

journal_title：Anticancer research

authors： Sehouli J,Woopen H,Pavel M,Richter R,Lauterbach LK,Taube E,Darb-Esfahani S,Fotopoulou C,Pietzner K

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND/AIM:Pre-neoplastic lesions and renal cell tumors of distinct pheno- and genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the role of KRT7 and KRT19 in this process, the expression of which was previously detected by Affymetrix GeneChip analysis. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Sarlos DP,Peterfi L,Szanto A,Kovacs G

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:Bladder cancer (BLCA, urothelial bladder cancer) is one of the most common malignancies with increasing incidence and mortality worldwide. Poor diagnosis and the limitation of treatment is still an unmet need in clinical practice. γδ T-Cells have been paid increasing attention because of their potent cyt...

journal_title：Anticancer research

authors： Pan Y,Chiu YH,Chiu SC,Cho DY,Lee LM,Wen YC,Whang-Peng J,Hsiao CH,Shih PH

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

journal_title：Anticancer research

authors： Mori S,Murakami-Mori K,Bonavida B

更新日期：1998-11-01 00:00:00

abstract：:The purpose of this study was to elucidate the behavior of signal transduction activity in rat and human carcinoma cells. Signal transduction activity was measured by the steady-state activity of the three enzymes involved in the conversion of 1-phosphatidylinositol (PI) to IP3, PI 4-kinase, PI 4-phosphate 5-kinase, a...

journal_title：Anticancer research

authors： Weber G,Shen F,Prajda N,Yeh YA,Yang H,Herenyiova M,Look KY

更新日期：1996-11-01 00:00:00

abstract：:The model of human malignant tumors, heterotransplanted and passaged into athymic nude mice, proved to be a valuable tool for nutritional oncology. It showed that several human tumors proliferate in distinct dependence on the available vitamin B6. A surplus of the vitamin causes enhancement of growth. Proliferation is...

journal_title：Anticancer research

authors： Fortmeyer HP,Timm C,Blum U,Wenisch HJ,Förster H

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND/AIM:The utility of nanoparticle albumin-bound paclitaxel (nab-PTX) monotherapy in patients with relapsed small-cell lung cancer (SCLC) has not been fully evaluated. We aimed to investigate the efficacy and safety of nab-PTX monotherapy in relapsed SCLC patients, including heavily treated patients. PATIENTS ...

journal_title：Anticancer research

authors： Nakao M,Fujita K,Suzuki Y,Arakawa S,Sakai Y,Sato H,Muramatsu H

更新日期：2020-03-01 00:00:00

abstract：:The aim of this study was to investigate whether multiple injections (daily for 5 days) of the hemorheological agent pentoxifylline (PTX) affected tumor physiological parameters (i.e., tumor pO2, tumor pH, and tumor interstitial fluid pressure) during the tumor growth of FSaII murine fibrosarcoma in C3H mice. The radi...

journal_title：Anticancer research

authors： Lee I,Biaglow JE,Lee J,Cho MJ

更新日期：2000-11-01 00:00:00

abstract：:The influence of human stromal fibroblasts cultured from normal, non-malignant and malignant breast tissues on in vivo growth of human breast tumour cells was studied. Earlier appearance and increased incidence were observed when low cell inocula of breast MDA-MB 231 tumour cells were coinjected with fibroblasts from ...

journal_title：Anticancer research

authors： Brouty-Boye D,Raux H

更新日期：1993-07-01 00:00:00

abstract：SPECIFIC OBJECTIVE:The Epidermal Growth Factor Receptor (EGFR) is a specific cell membrane receptor that shows homology to the product of the oncogene c-erbB2 in human breast cancer. Growth factors bound to the EGFR are able to stimulate the growth of tumor cells in an autocrine or paracrine manner. Our objective was t...

journal_title：Anticancer research

authors： Oehler MK,Rehn M,Kristen P,Sütterlin M,Caffier H

更新日期：1997-07-01 00:00:00

abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...

journal_title：Anticancer research

authors： Shultz TD,Chew BP,Seaman WR

更新日期：1992-11-01 00:00:00

abstract：AIM:To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Twenty-one NSCLC patients who underwent sur...

journal_title：Anticancer research

authors： Takamori S,Toyokawa G,Okamoto I,Takada K,Kozuma Y,Matsubara T,Haratake N,Akamine T,Katsura M,Mukae N,Shoji F,Okamoto T,Oda Y,Iwaki T,Iihara K,Nakanishi Y,Maehara Y

更新日期：2017-08-01 00:00:00

abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...

journal_title：Anticancer research

authors： Krizková L,Duracková Z,Sandula J,Slamenová D,Sasinková V,Sivonová M,Krajcovic J

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:In the last few years, several prognostic factors have been investigated in order to identify among patients with completely resected non-small cell lung cancer (NSCLC) subsets at high risk of recurrence. In this context, the actual role of serum tumour markers is still unclear. The aim of this study was to ...

journal_title：Anticancer research

authors： Foa P,Fornier M,Miceli R,Seregni E,Santambrogio L,Nosotti M,Cataldo I,Sala M,Caldiera S,Bombardieri E

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The antiemetic effects of serotonin receptor antagonists during chemoradiotherapy for solid tumors have never been reported. We have developed hyperthermo-chemo-radiotherapy (HCR) for esophageal cancer. However, with this treatment, the more potent the chemotherapy was, the more frequently emesis was experie...

journal_title：Anticancer research

authors： Morita M,Kuwano H,Ohno S,Kitamura K,Sugimachi K

更新日期：2000-09-01 00:00:00

abstract：:To identify retinoic acid (RA) signalling pathways involved in growth and differentiation in cells of the glial lineage, two human glioma ceh lines were studied. The three RA receptors (RARs) mRNAs were constitutively expressed, and of the three RXRs, RXR beta appeared predominant. Western blotting analysis confirmed ...

journal_title：Anticancer research

authors： Carpentier AF,Leonard N,Lacombe J,Zassadowski F,Padua RA,Degos L,Daumas-Duport C,Chomienne C

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Hypoxia represents an important tumor-specific target for cancer therapy. We have reported that hypoxic cytotoxins, such as TX-1102, tirapazamine (TPZ) and TX-402, selectively induced tumor cells to p53-independent apoptosis under hypoxic conditions and inhibited angiogenesis. MATERIALS AND METHODS:We inves...

journal_title：Anticancer research

authors： Nagasawa H,Mikamo N,Nakajima Y,Matsumoto H,Uto Y,Hori H

更新日期：2003-11-01 00:00:00

abstract：:Glutathione (GSH) concentration is high in most tumour cells and this may be an important factor in resistance to chemotherapy. Previous in-vitro and animal experiments have shown a differential response of tumour versus normal cells to various cysteine delivery systems. More specifically, an in-vitro assay showed tha...

journal_title：Anticancer research

authors： Kennedy RS,Konok GP,Bounous G,Baruchel S,Lee TD

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND/AIM:In the present article we review on the use of Volumetric Modulated Arc Therapy (VMAT) for a small lung nodule that was centrally located in close proximity to the mediastinal structures. CASE REPORT:An inoperable patient with central, clinical stage IA adenocarcinoma of the right lung was treated with ...

journal_title：Anticancer research

authors： Valakh V,Chan P,D'Adamo K,Micaily B

更新日期：2013-10-01 00:00:00