Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.

abstract：:Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...

journal_title：Developmental biology

authors： Gaboriau D,Howes EA,Clark J,Jones R

更新日期：2007-06-15 00:00:00

abstract：:Urodeles begin gastrulation with much of their presumptive mesoderm in the superficial cell layer, all of which must move into the deep layers during development. We studied the morphogenesis of superficial mesoderm in the urodeles Ambystoma maculatum, Ambystoma mexicanum, and Taricha granulosa. In all three species, ...

journal_title：Developmental biology

authors： Shook DR,Majer C,Keller R

更新日期：2002-08-15 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:The ciliated band of the Strongylocentrotus purpuratus embryo consists of a columnar epithelium, 3-5 cells wide, which gives rise to a small number of neuroblasts. It arises late in development, as a border separating the squamous epithelial cells of the oral and aboral ectoderm. To determine the lineage origins of th...

journal_title：Developmental biology

authors： Cameron RA,Britten RJ,Davidson EH

更新日期：1993-12-01 00:00:00

abstract：:We describe the identification, biochemical characterisation, and mutation of a novel mouse gene: Sp5. Sp5 encodes a protein having a C-terminal C(2)H(2) zinc finger domain closely related to that of the transcription factor Sp1. In vitro, DNA binding studies show that it binds to the GC box, a DNA motif present in th...

journal_title：Developmental biology

authors： Harrison SM,Houzelstein D,Dunwoodie SL,Beddington RS

更新日期：2000-11-15 00:00:00

abstract：:A cDNA library was used to measure changes in many individual mRNAs during muscle differentiation in culture. A library of 1000 clones was constructed from total myofiber poly(A) RNA. About 23% of these clones gave a detectable colony hybridization signal using end-labeled myofiber mRNA, the remainder containing muscl...

journal_title：Developmental biology

authors： Devlin RB,Haskell SG

更新日期：1983-02-01 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:In many organisms, like Caenorhabditis elegans and Drosophila melanogaster, establishment of spatial patterns and definition of cell fate are driven by the segregation of determinants in response to spatial cues, as early as oogenesis or fertilization. In these organisms, a family of conserved proteins, the PAR protei...

journal_title：Developmental biology

authors： Vinot S,Le T,Ohno S,Pawson T,Maro B,Louvet-Vallée S

更新日期：2005-06-15 00:00:00

abstract：:Human MusTRD1alpha1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (TnIslow USE) and was predicted to be a regulator of slow fiber-specific genes. To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1alpha1 in skeletal muscle....

journal_title：Developmental biology

authors： Issa LL,Palmer SJ,Guven KL,Santucci N,Hodgson VR,Popovic K,Joya JE,Hardeman EC

更新日期：2006-05-01 00:00:00

abstract：:Pronuclear migration and formation of the first mitotic spindle depend upon assembly of a functional zygotic centrosome. For most animals, this involves both paternal and maternal contributions as sperm basal bodies are converted into centrosomes competent for microtubule nucleation through recruitment of egg proteins...

journal_title：Developmental biology

authors： Twomey C,Wattam SL,Pillai MR,Rapley J,Baxter JE,Fry AM

更新日期：2004-01-15 00:00:00

abstract：:In amphibians, the composition and pattern of expression of the myosin heavy chain (myHC) gene family are mostly unknown. To understand better the regulation of this complex family, we screened cDNA libraries from swimming tadpole and adult leg muscle RNA and have isolated and partially sequenced clones for several my...

journal_title：Developmental biology

authors： Radice GP,Malacinski GM

更新日期：1989-06-01 00:00:00

abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

journal_title：Developmental biology

authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

更新日期：2014-06-15 00:00:00

abstract：:Lens growth involves the proliferation of epithelial cells, followed by their migration to the equator region and differentiation into secondary fiber cells. It is widely accepted that fibroblast growth factor (FGF) signaling is required for the differentiation of lens epithelial cells into crystallin-rich fibers, but...

journal_title：Developmental biology

authors： Song X,Sato Y,Felemban A,Ito A,Hossain M,Ochiai H,Yamamoto T,Sekiguchi K,Tanaka H,Ohta K

更新日期：2012-08-01 00:00:00

abstract：:The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories. Unlike measurement of a continuous variable, categorical data cannot be analyzed with methods such as the Student's t-test. Thus, these data require a different method of ...

journal_title：Developmental biology

authors： Xu B,Feng X,Burdine RD

更新日期：2010-12-01 00:00:00

abstract：:Activation of progenitor cells is crucial to promote tissue repair following injury in adult animals. In the context of successful limb regeneration following amputation, progenitor cells residing within the stump must re-enter the cell cycle to promote regrowth of the missing limb. We demonstrate that in axolotls, am...

journal_title：Developmental biology

authors： Johnson K,Bateman J,DiTommaso T,Wong AY,Whited JL

更新日期：2018-01-15 00:00:00

abstract：:The development of supernumerary bristle precursors induced by the mutation shaggy (sgg; also known as zeste-white 3) was examined in the developing wing blade of imaginal and pupal Drosophila. sgg clones were induced by mitotic recombination; clones were marked using enhancer-trap flies which express beta-galactosida...

journal_title：Developmental biology

authors： Blair SS

更新日期：1992-08-01 00:00:00

abstract：:An anterior-posterior concentration difference of fibronectin associated with the endoderm in early chick embryos has been implicated in the directional migration of precardiac mesoderm cells. We have examined the effect of increasing concentrations of an antibody to fibronectin (FN) to test the essentiality of FN to ...

journal_title：Developmental biology

authors： Linask KK,Lash JW

更新日期：1988-10-01 00:00:00

abstract：:The Drosophila homeobox gene tinman and its vertebrate homologs Nkx-2.5 and Nkx-2.3 are critical determinants of cardiac development. We report here the identification of a new tinman-related gene, nkx2.7, as well as orthologs of Nkx-2.5 and Nkx-2.3 in the zebrafish. Analysis of their expression in the developing zebr...

journal_title：Developmental biology

authors： Lee KH,Xu Q,Breitbart RE

更新日期：1996-12-15 00:00:00

abstract：:We have examined the presence of protein kinase C in oocytes of Chaetopterus pergamentaceus and its role in the initiation of germinal vesicle breakdown (GVBD). First, we demonstrated that the oocytes contain a phospholipid- and calcium-dependent protein kinase, protein kinase C (PKC). Since PKC is the primary intrace...

journal_title：Developmental biology

authors： Eckberg WR,Palazzo RE

更新日期：1992-02-01 00:00:00

abstract：:Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of...

journal_title：Developmental biology

authors： Donjacour AA,Thomson AA,Cunha GR

更新日期：2003-09-01 00:00:00

abstract：:The expression of heat shock genes is induced in all living cells by a series of proteotoxic treatments. Heat shock genes are also activated spontaneously during different phases of embryonic development. HSP89 alpha and HSC70 are expressed at a high level in the mouse blastocyst. A family of factors, called HSFs, are...

journal_title：Developmental biology

authors： Mezger V,Rallu M,Morimoto RI,Morange M,Renard JP

更新日期：1994-12-01 00:00:00

abstract：:The embryonic cell lineage of Caenorhabditis elegans has been traced from zygote to newly hatched larva, with the result that the entire cell lineage of this organism is now known. During embryogenesis 671 cells are generated; in the hermaphrodite 113 of these (in the male 111) undergo programmed death and the remaind...

journal_title：Developmental biology

authors： Sulston JE,Schierenberg E,White JG,Thomson JN

更新日期：1983-11-01 00:00:00

abstract：:Conserved from Cnidarians to vertebrates, the dorsoventral (DV) axis is patterned by the Chordin-BMP pathway. However, the functions of the pathway's components are very different in different phyla. By modeling it is shown that many observations can be integrated by the assumption that BMP, acting as an inhibitory co...

journal_title：Developmental biology

authors： Meinhardt H

更新日期：2015-09-01 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:A polarity in gap junctional permeability normally exists in 32-cell stage Xenopus embryos, in that dorsal cells are relatively more coupled than ventral cells, as measured by transfer of Lucifer yellow dye. The current study extends our analysis of whether gap junctional permeability at this stage can be modulated by...

journal_title：Developmental biology

authors： Olson DJ,Moon RT

更新日期：1992-05-01 00:00:00

abstract：:Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shield, a region of the embryo functionally analogous to the amphibian Spemann organizer. We report that the bozozok locus encodes the transcription factor nieuwkoid/dharma, a homeobox gene with non-cell-autonomous organize...

journal_title：Developmental biology

authors： Koos DS,Ho RK

更新日期：1999-11-15 00:00:00

abstract：:Although a large superfamily of G-protein-coupled receptors serves multiple functions, little is known about their functional activation during ontogeny. To examine the functional activation of the mu-opioid receptor (MOR) and the delta-opioid receptor (DOR) during development, sections of mouse embryos and fetuses fr...

journal_title：Developmental biology

authors： Nitsche JF,Pintar JE

更新日期：2003-01-01 00:00:00

abstract：:Embryonic kidney development begins with the outgrowth of the ureteric bud (UB) from the Wolffian duct (WD) into the adjacent metanephric mesenchyme (MM). Both a GDNF-dependent and GDNF-independent (Maeshima et al., 2007) pathway have been identified. In vivo and in vitro, the GDNF-dependent pathway is inhibited by BM...

journal_title：Developmental biology

authors： Tee JB,Choi Y,Shah MM,Dnyanmote A,Sweeney DE,Gallegos TF,Johkura K,Ito C,Bush KT,Nigam SK

更新日期：2010-11-15 00:00:00

abstract：:The fertilized ascidian egg is thought to be comprised of distinct regions of tissue-specific cytoplasmic determinants. This idea was tested by bisecting fertilized eggs into egg fragments and culturing them until the unoperated controls developed into larvae. Fertilized eggs were bisected using a microsurgical method...

journal_title：Developmental biology

authors： Bates WR

更新日期：1988-09-01 00:00:00

abstract：:The fate of bacteriophage lambda-DNA was examined after injection into the fertilized eggs of Xenopus laevis. Injection of a large amount of lambda-DNA (ca. 24 ng) into a fertilized Xenopus egg induced the formation around the injected DNA of a giant nucleus-like structure which was surrounded by an apparently normal ...

journal_title：Developmental biology

authors： Shiokawa K,Sameshima M,Tashiro K,Miura T,Nakakura N,Yamana K

更新日期：1986-08-01 00:00:00