Effect of Lomodex-MgSO(4) in the prevention of reperfusion injury following unilateral testicular torsion: an experimental study in rats.

Abstract:

:Fertility in patients treated for unilateral testicular torsion has been shown to be significantly reduced in all the reported series to date, implying that the present-day treatment requires further refinement in the form of adjunct pharmacotherapeutic intervention (Lomodex and MgSO(4)) in addition to scrotal exploration. Prepubertal Holtzman strain rats (35 days old) were used for our study. Two sets were formed with six groups of rats in each set. Rats were treated as follows: group 1, sham-operated group; group 2, torsion (4 h); group 3, torsion + detorsion (1 h); group 4, torsion + ATP-MgCl(2) + detorsion; group 5, torsion + Lomodex-MgSO(4) + detorsion; group 6, torsion + normal saline + detorsion. Whereas the first set of animals was sacrificed immediately at the end of experiment, animals in set 2 were sacrificed 8 weeks after the end of the experiment to look for the development of antisperm antibodies. Parameters studied were thiobarbituric acid reductase (TBAR) assay, histology of testicular tissue, and sperm agglutination test. Student's t-test was used for significance. With detorsion (149.95+/-30.68) there was a significant rise in the TBAR values (P<0.05) compared with torsion (57.39+/-14.47). Treatment with both Lomodex-MgSO(4) (40.74+/-6.39) and ATP-MgCl(2) (48.30+/-18.35) yielded TBAR levels comparable to those in the sham group (31.35+/-11.96). Similar injury was also seen on the contralateral testis, with detorsion (114.28+/-10.68) much more detrimental than torsion (40.59+/-15.02) and rescue seen following treatment with Lomodex-MgSO(4) (27.55+/-8.64) as well as ATP-MgCl(2) (38.61+/-12.23). Regarding th histology, with detorsion there was evidence of severe distortion of tubules, with almost all the tubules showing maturation arrest and a few tubules completely devoid of any germinal cells. Treatment with Lomodex-MgSO(4) as well as ATP-MgCl(2) showed preservation of tubular morphology. Our study failed to document the presence of agglutinating antibodies (antisperm antibodies) in any of the groups. Unilateral testicular torsion has bilateral effects and is a form of ischemia-reperfusion injury. Treatment of torsion by detorsion alone does not prevent testicular damage. The results of the present study show that administration of Lomodex + MgSO(4) prior to detorsion results in prolonged testicular salvage with a potential of subsequent improvement in semen quality and fertility and reduction in long-term morbidity. The presence of agglutinating antibodies could not be detected in the present study.

journal_name

Pediatr Surg Int

authors

Adivarekar PK,Bhagwat SS,Raghavan V,Bandivdekar AH

doi

10.1007/s00383-004-1317-1

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

184-90

issue

3

eissn

0179-0358

issn

1437-9813

journal_volume

21

pub_type

杂志文章
  • Semen analysis in post-pubertal patients with posterior urethral valves: a pilot study.

    abstract::The issues of sexual function and fertility are becoming relevant in patients with posterior urethral valves (PUV), as more of them reach adulthood. To evaluate the semen of post-pubertal patients with PUV as a determinant of future fertility, all such patients (age >16 years) attending the follow-up urology clinic of...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830100679

    authors: Puri A,Gaur KK,Kumar A,Bhatnagar V

    更新日期:2002-03-01 00:00:00

  • Feasibility of complex minimally invasive surgery in neonates.

    abstract::The aim of this study was to assess the feasibility of complex minimally invasive surgery in neonates (and infants <5 kg). A systematic search of databases was performed. Inguinal herniotomy and pyloromyotomy were specifically excluded. Various operations were assessed for operative times, conversion rates, complicati...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-008-2318-2

    authors: Sinha CK,Paramalingam S,Patel S,Davenport M,Ade-Ajayi N

    更新日期:2009-03-01 00:00:00

  • Stroma-predominant Wilms tumor with teratoid features: report of a rare case and review of the literature.

    abstract::We describe the case of a 4-year-old boy with a unilateral right-sided Wilms tumor with stromal predominance and teratoid features, which was localized to the kidney and hence, was completely resected. The pediatric surgeon and pathologist, both should be aware of this rare appearance of nephroblastoma so as to avoid ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-009-2333-y

    authors: Gupta R,Sharma A,Arora R,Dinda AK

    更新日期:2009-03-01 00:00:00

  • Open versus laparoscopic approach for intestinal malrotation in infants and children: a systematic review and meta-analysis.

    abstract:PURPOSE:Although the principles of the Ladd's procedure for intestinal malrotation in children have remained unchanged since its first description, in the era of minimally invasive surgery it is controversial whether laparoscopy is advantageous over open surgery. The aim of our study was to determine whether the surgic...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00383-016-3974-2

    authors: Catania VD,Lauriti G,Pierro A,Zani A

    更新日期:2016-12-01 00:00:00

  • Factors responsible for successful primary closure in bladder exstrophy.

    abstract::To assess the important factors for successful primary closure in staged reconstruction of bladder exstrophy, 25 patients (18 males, 7 females) underwent primary bladder closure during the years 1993-1997. Twenty-one were more than 72 h old; all of these underwent bilateral posterior iliac osteotomies followed by prim...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050721

    authors: Kasat LS,Borwankar SS

    更新日期:2000-01-01 00:00:00

  • Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung's disease.

    abstract::Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the in...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-007-2044-1

    authors: O' Donnell AM,Puri P

    更新日期:2008-01-01 00:00:00

  • Surgical intervention for congenital diaphragmatic hernia: open versus thoracoscopic surgery.

    abstract:PURPOSE:To compare open repair (OR) with thoracoscopic repair (TR) for congenital diaphragmatic hernia (CDH) in neonates. METHODS:Twenty-four neonatal CDH cases diagnosed prenatally or within 6 h of birth at our institute from 2002 to 2012 with mild pulmonary hypertension managed without inhaled nitric oxide, were stu...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-013-3382-9

    authors: Tanaka T,Okazaki T,Fukatsu Y,Okawada M,Koga H,Miyano G,Ogasawara Y,Lane GJ,Yamataka A

    更新日期:2013-11-01 00:00:00

  • Cholelithiasis in early infancy.

    abstract::This report describes three children, age range 7 weeks to 5 months, who presented with obstructive jaundice secondary to gallstones. Previous Escherichia coli septicaemia and frusemide therapy were predisposing risk factors in two of the patients. All three were successfully treated with cholecystectomy and explorati...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:

    authors: Wilcox DT,Casson D,Bowen J,Thomas A,Bruce J

    更新日期:1997-02-01 00:00:00

  • Effect of leflunomide on liver regeneration after partial hepatectomy in rats.

    abstract:PURPOSE:Partial hepatectomy (PH) can be an inevitable surgical therapy in some conditions, such as hepatic malignancies, trauma or partial liver transplantation. Its capacity for regeneration distinguishes the liver from other essential organs. Regeneration is a complex process involving growth factors, cytokines, tran...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-009-2529-1

    authors: Karaman A,Kirimlioglu H,Tas E,Karadag N,Gülsul C,Fadillioglu E,Demircan M

    更新日期:2010-02-01 00:00:00

  • Ovarian and multiple lymph nodes recurrence of acute lymphoblastic leukemia: a case report and review of literature.

    abstract::Ovarian involvement of acute lymphoblastic leukemia (ALL) without relapse in the bone marrow or other extramedullary site is rare. We report a case of ovarian relapse in a 13-year-old girl who was diagnosed with ALL at the age of 11. A complete remission was induced with the Children Cancer Group 1882 protocol for hig...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章,评审

    doi:10.1007/s00383-008-2253-2

    authors: Kim JW,Cho MK,Kim CH,Kang WD,Kook H,Kim YH,Choi HS,Kim SM

    更新日期:2008-11-01 00:00:00

  • Delayed diagnosis of imperforate anus: an unacceptable morbidity.

    abstract:PURPOSE:Diagnosis of imperforate anus is usually made shortly after birth with physical examination. Nonetheless, a significant number of patients have presented beyond the neonatal period without recognition of anorectal malformation. We reviewed our experience of anorectal malformations, with particular emphasis on t...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-010-2691-5

    authors: Turowski C,Dingemann J,Gillick J

    更新日期:2010-11-01 00:00:00

  • Long-term outcome of surgically managed necrotizing enterocolitis in a developing country.

    abstract:UNLABELLED:Necrotizing enterocolitis (NEC) is a serious condition with a high morbidity and mortality commonly affecting premature babies. Data for the impact of the long-term disease burden in developing countries are limited although poor long-term outcome of surgically managed patients has been shown in terms of inc...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-010-2583-8

    authors: Arnold M,Moore SW,Sidler D,Kirsten GF

    更新日期:2010-04-01 00:00:00

  • Long-term functional results following resection of neonatal sacrococcygeal teratoma.

    abstract:PURPOSE:Sacrococcygeal teratoma (SCT) is the most common congenital neoplasm in neonates. We wished to assess the long-term functional outcome of children undergoing SCT resection. METHODS:Records of neonates diagnosed with SCT from two surgeons' practices, and operated on between 1970 and 2006, were retrospectively r...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-009-2322-1

    authors: Draper H,Chitayat D,Ein SH,Langer JC

    更新日期:2009-03-01 00:00:00

  • T-cryptantigen (TCA) activation in surgical neonates: a hidden problem.

    abstract::The Thomsen-Friedenreich cryptantigen (TCA) is located on the surface of all red cells, but is concealed by a layer of neuraminic acid. When bacteria that produce neuraminidase disrupt this coating, the TCA can be exposed and activated. If blood products containing antibody to the TCA are subsequently administered, ha...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050488

    authors: Grant HW,Hadley GP,Adhikari M,Fernandes-Costa F

    更新日期:1998-12-01 00:00:00

  • Ductoplasty for an aberrant hepatic duct in a choledochal cyst.

    abstract::The confluence of the right and left hepatic ducts at the hepatic hilum frequently shows normal anatomic variations. Choledochal cysts (CC) are also accompanied by similar variations, and devices for free drainage of bile are occasionally required in biliary reconstruction. We present a CC that had an aberrant posteri...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/BF01371914

    authors: Todani T,Watanabe Y,Toki A,Sato Y,Ogura K,Yamamoto S,Furuta Y

    更新日期:1997-01-01 00:00:00

  • Pediatric living donor liver transplantation for biliary atresia with hepatopulmonary syndrome: the gift of a second wind.

    abstract:PURPOSE:Hepatopulmonary syndrome (HPS) is a progressive, deteriorating complication of end-stage liver disease (ESLD) that occurs in 13-47% of liver transplant candidates. Although LT is the only therapeutic option for HPS, it has a high morbidity and mortality, especially in patients with severe hypoxemia before trans...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-011-2866-8

    authors: Urahashi T,Mizuta K,Sanada Y,Umehara M,Wakiya T,Hishikawa S,Hyodo M,Sakuma Y,Fujiwara T,Yasuda Y,Kawarasaki H

    更新日期:2011-08-01 00:00:00

  • Conservative management of splenic trauma: history and current trends.

    abstract::Evolution of the present-day policy of conservative management of ruptured spleen has been hailed as one of the most notable advances in pediatric surgery. Until 1971, routine splenectomy used to be the sacrosanct treatment for splenic trauma. It was universally believed that non-operative management carried a high mo...

    journal_title:Pediatric surgery international

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s00383-003-0972-y

    authors: Upadhyaya P

    更新日期:2003-11-01 00:00:00

  • Postoperative abdominal evisceration in children: possible risk factors.

    abstract::Postoperative abdominal evisceration may lead to high morbidity and mortality. The purpose of the present study was to determine possible risk factors, morbidity and mortality associated with abdominal evisceration in children. A total of 3,591 children underwent abdominal exploration in our clinic between 1983 and 20...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-006-1722-8

    authors: Ciğdem MK,Onen A,Otçu S,Duran H

    更新日期:2006-08-01 00:00:00

  • Laparoscopic surgery for acute neonatal appendicitis.

    abstract::We present the first two cases of acute neonatal appendicitis operated on through the laparoscopic approach. Acute neonatal appendicitis is uncommon and rarely considered by clinicians when assessing the neonatal acute abdomen. Our two cases demonstrate the potential value of diagnostic laparoscopy in the acute neonat...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-011-2972-7

    authors: Malakounides G,John M,Rex D,Mulhall J,Nandi B,Mukhtar Z

    更新日期:2011-11-01 00:00:00

  • Surgical reconstruction and endoscopic pancreatic stent for traumatic pancreatic duct disruption.

    abstract::Nonoperative management is acceptable treatment for minor pancreatic injuries. However, management of major pancreatic duct injury in children remains controversial. We present our experience in treating isolated pancreatic duct injury. We describe the cases of three male patients treated for complete pancreatic duct ...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-014-3570-2

    authors: Kawahara I,Maeda K,Ono S,Kawashima H,Deie R,Yanagisawa S,Baba K,Usui Y,Tsuji Y,Fukuta A,Sekine S

    更新日期:2014-09-01 00:00:00

  • Post-chemotherapy microscopic residual prostate rhabdomyosarcoma: long-term conservative follow-up.

    abstract::In spite of advances in the treatment of childhood bladder and prostate rhabdomyosarcoma (RMS), the ability to detect minimal residual disease correlates imperfectly with the ultimate outcome. We report the long-term follow-up of a child with microscopic residual RMS after chemotherapy. The correct interpretation of t...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830200017

    authors: Chertin B,Reinus C,Koulikov D,Rosenmann E,Farkas A,Chertin B

    更新日期:2002-01-01 00:00:00

  • The area and attachment abnormalities of the gubernaculum in patients with undescended testes in comparison with those with retractile testes.

    abstract:PURPOSE:In order to evaluate the gubernaculum (GN) abnormalities quantitatively in patients with undescended testes (UDT), the area and attachment site of the gubernaculum were evaluated. PATIENTS AND METHODS:Sixty-seven testes from 61 patients with an undescended testis treated in the past 11 years at our institution...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-014-3597-4

    authors: Kubota M,Nakaya K,Arai Y,Ohyama T,Yokota N,Nagai Y

    更新日期:2014-11-01 00:00:00

  • The impact of Down's syndrome on the immediate and long-term outcomes of children with Hirschsprung's disease.

    abstract::Hirschsprung's disease (HD) in Down's syndrome (DS) patients is stated to have a worse outcome than HD alone. In our study we reviewed the immediate and long-term outcomes of these children and questioned whether DS should influence the operative management. Data were collected on all children with HD (including total...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-005-1617-0

    authors: Morabito A,Lall A,Gull S,Mohee A,Bianchi A

    更新日期:2006-02-01 00:00:00

  • Congenital cystic mesoblastic nephroma.

    abstract::With widespread use of antenatal ultrasound, an increasing number of urinary-tract lesions are being detected, and the clinician is called upon to make management decisions. Parenchymal lesions of the kidney pose a special challenge because of the associated risk of the occurrence of malignancy. A case of an antenatal...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-002-0833-0

    authors: Murthi GV,Carachi R,Howatson A

    更新日期:2003-04-01 00:00:00

  • Outcomes and management of rectal injuries in children.

    abstract::In the pediatric population, rectal injuries usually occur as a result of motor vehicle collisions. There has been an increased interest in selective diversion of rectal injuries in adults and increased utilization of laparoscopy both as a diagnostic and therapeutic adjunct. The aim of the study was to review our inst...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-007-1996-5

    authors: Bonnard A,Zamakhshary M,Wales PW

    更新日期:2007-11-01 00:00:00

  • Neonatal surgery in low- vs. high-volume institutions: a KID inpatient database outcomes and cost study after repair of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis.

    abstract:BACKGROUND/PURPOSE:The volume-outcome relationship and optimal surgical volumes for repair of congenital anomalies in neonates is unknown. METHODS:A retrospective study of infants who underwent diaphragmatic hernia (CDH), gastroschisis (GS), and esophageal atresia/tracheoesophageal fistula (EA/TEF) repair at US hospit...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-019-04525-x

    authors: Sømme S,Shahi N,McLeod L,Torok M,McManus B,Ziegler MM

    更新日期:2019-11-01 00:00:00

  • The frequency, significance, and management of a right aortic arch in association with esophageal atresia.

    abstract::An unrecognised right aortic arch (RAA) found at thoracotomy may complicate the repair of oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF). This paper analyses the patient characteristics, peri-operative management, and outcome of 16 infants with a RAA, and proposes management guidelines. Between 1948 an...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s003830050505

    authors: Bowkett B,Beasley SW,Myers NA

    更新日期:1999-01-01 00:00:00

  • Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication?

    abstract:AIM:An experimental study was performed to investigate the efficacy of colchicine in the prevention of fibrosis in the alkaline burn of the esophagus in rats. METHOD:A standard esophageal alkaline burn was produced by the application of 37.5% NaOH for a period of 90 s to the distal esophagus followed by a water rinse....

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-006-1644-5

    authors: Yukselen V,Vardar E,Yukselen O,Karaoglu AO,Yenisey C,Ozutemiz O

    更新日期:2006-04-01 00:00:00

  • Antegrade balloon dilation of postoperative ureterovesical junction obstruction in children.

    abstract::Obstruction of the ureterovesical junction is an uncommon but well-recognized complication of ureteral reimplantation that traditionally has been treated by surgical correction [1, 5-9]. We report our experience with antegrade balloon dilation (ABD) of these strictures in two children. Obstruction was confirmed by diu...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/BF00626067

    authors: Angel CA,Kocurek JN,Walser EM,Wittich GR,Warren MM,Swischuk LE

    更新日期:1996-10-01 00:00:00

  • Surgical intervention in vascular trauma in children.

    abstract:UNLABELLED:Vascular trauma is uncommon in children but may be complex. Arterial injury in children presents a challenge to the surgeon and may have long-term implications. Children have major advantage of a rich-collateral circulation but are still growing and developing. Decisions about when to operate remain an issue...

    journal_title:Pediatric surgery international

    pub_type: 杂志文章

    doi:10.1007/s00383-011-3033-y

    authors: Tshifularo N,Moore SW

    更新日期:2012-04-01 00:00:00