Abstract：
:Hypericin is a naturally occurring substance found in the common St. John's Wort (Hypericum species) and can also be synthesized from the anthraquinone derivative emodin. As the main component of Hypericum perforatum, it has traditionally been used throughout the history of folk medicine. In the last three decades, hypericin has also become the subject of intensive biochemical research and is proving to be a multifunctional agent in drug and medicinal applications. Recent studies report antidepressive, antineoplastic, antitumor and antiviral (human immunodeficiency and hepatitis C virus) activities of hypericin; intriguing information even if confirmation of data is incomplete and mechanisms of these activities still remain largely unexplained. In other contemporary studies, screening hypericin for inhibitory effects on various pharmaceutically important enzymes such as MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450), has yielded results supporting therapeutic potential. Research of hypericin and its effect on GABA-activated (gamma amino butyric acid) currents and NMDA (N-methyl-D-aspartat) receptors also indicate the therapeutic potential of this substance whereby new insights in stroke research (apoplexy) are expected. Also in the relatively newly established fields of medical photochemistry and photobiology, intensive research reveals hypericin to be a promising novel therapeutic and diagnostic agent in treatment and detection of cancer (photodynamic activation of free radical production). Hypericin is not new to the research community, but it is achieving a new and promising status as an effective agent in medical diagnostic and therapeutic applications. New, although controversial data, over the recent years dictate further research, re-evaluation and discussion of this substance. Our up-to-date summary of hypericin, its activities and potentials, is aimed to contribute to this process.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Kubin A,Wierrani F,Burner U,Alth G,Grünberger Wdoi
10.2174/1381612053382287subject
Has Abstractpub_date
2005-01-01 00:00:00pages
233-53issue
2eissn
1381-6128issn
1873-4286journal_volume
11pub_type
杂志文章,评审abstract：:Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known t...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612811319180008
更新日期：2013-01-01 00:00:00
abstract：:During the last two decades, the studies on ubiquitination in regulating transcription factor NF-κB activation have elucidated the expanding role of ubiquitination in modulating cellular events by non-proteolytic mechanisms, as well as by proteasomal degradation. The significance of ubiquitination has also been recogn...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612811319180010
更新日期：2013-01-01 00:00:00
abstract：:In the stomach, pre-absorptive perception of food constituents is of particular importance in maintaining secretion and motility that matches the quantity and quality of nutrients. Products of food protein hydrolysis, free amino acids and short peptides, are the most potent chemical stimulants of the gastric phase of ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/13816128113199990581
更新日期：2014-01-01 00:00:00
abstract：:Aspirin is an antiplatelet drug, inhibiting the cyclooxygenase activity of platelet prostaglandin H synthase-1 and almost complete suppressing platelet capacity to generate the prothrombotic and proatherogenic thromboxane A2. Antiplatelet therapy with aspirin reduces the risk of serious vascular events by about a quar...
journal_title：Current pharmaceutical design
pub_type： 历史文章,杂志文章,评审
doi：10.2174/138161212803251943
更新日期：2012-01-01 00:00:00
abstract：:Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs)...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612825666191113104946
更新日期：2019-01-01 00:00:00
abstract：:Multiple Sclerosis (MS) is the most common autoimmune demyelinating disorder in Western countries and can lead to permanent disability. Over the past decades remarkable progress has been made in providing new therapeutic strategies to tackle the burden of the disease. Oral drugs and monoclonal antibodies are the main ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161211798157630
更新日期：2011-01-01 00:00:00
abstract：:Our clinical observations proved that the the duodenal ulcer in patients healed without any inhibition of gastric acid secretion (1965), and the healing rates of atropine vs cimetidine vs Carbenoxolone were equal and superior to that of placebo in randomized, prospective and multiclinical study of DU patients (1978). ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161211796197016
更新日期：2011-01-01 00:00:00
abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161208784705441
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666161208142617
更新日期：2017-01-01 00:00:00
abstract：:α-Synuclein aggregation is centrally implicated in Parkinson's disease (PD). It involves multi-step nucleated polymerization process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound viz., Curcumin-glucoside (Curc-gluc), a modified form of...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161212798919093
更新日期：2012-01-01 00:00:00
abstract：:Nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as a feeding-suppressing neuropeptide, acting at central (mainly, hypothalamic) levels in a leptin-independent manner. However, recent experimental evidence strongly suggests that, rather than being a simple anorectic hypothala...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161281939131127142531
更新日期：2013-01-01 00:00:00
abstract：:In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa's and that protonation states frequently change from unbound to bound states. These protonation ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612811319230004
更新日期：2013-01-01 00:00:00
abstract：:The phenomenon of blood serum atherogenicity was described as the ability of human serum to induce lipid accumulation in cultured cells. The results of recent two-year prospective study in asymptomatic men provided the evidence for association between the changes in serum atherogenicity and dynamics of carotid intima-...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/1381612820666140212194614
更新日期：2014-01-01 00:00:00
abstract：:We estimated the frequency of detection of different human papillomavirus (HPV) types in women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology in a population-based primary screening programme. 247 liquid-based cytology (LBC) samples with A...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:Cytokines are known to play a key role in regulation of gastric functions. Interferon-alpha (IFN-α) has been published to impair gastric motility. Aims of this study were to clarify effect of IFN-α on gastric acid secretion (GAS) and determine role of nitric oxide (NO) in the process. Both subcutaneous (1000, 10000, 1...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/13816128130104
更新日期：2013-01-01 00:00:00
abstract：:Cancer therapies through ionizing radiation or chemotherapeutic treatment may result in DNA double strand breaks (DSBs) in cell. DNA-PK has emerged as an attractive target for drug discovery efforts toward DSBs repair and in V(D)J recombination. Hence, the search for potent and selective DNA-PK inhibitors has received...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161209789649484
更新日期：2009-01-01 00:00:00
abstract：:Chronic pain is a widespread healthcare problem affecting not only the patient but in many ways all the society. Chronic pain is a disease itself that endures for a long period of time and it is resistant to the majority of medical treatments that provide modest improvements in pain and minimum improvements in physica...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612820666140314150634
更新日期：2014-01-01 00:00:00
abstract：:Oncology remains an increasingly important focus of therapeutic development yet there remain many scientific and operational bottlenecks to deliver optimum treatments efficiently. Radiopharmaceuticals constitute a group of methodologies able to support the many stages of drug development. Methods such as [(18)F]-FDG-P...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161209787581977
更新日期：2009-01-01 00:00:00
abstract：:Angiogenesis is regulated by stimulators and inhibitors and involve multiple biological processes including endothelial cell proliferation, migration, cell-cell and cell-matrix adhesion, assembly into tube structures as well as apoptosis. Designing and developing peptides for therapeutic application to inhibit angioge...
journal_title：Current pharmaceutical design
pub_type： 杂志文章
doi：10.2174/138161207781039715
更新日期：2007-01-01 00:00:00
abstract：:Aspirin is the cornerstone of treatment in patients with coronary artery disease. However, several studies investigating the in vitro response of platelets to the administration of aspirin showed this response to be variable, with some patients exhibiting non-responsiveness or resistance. Aspirin resistance may be cat...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161209787846964
更新日期：2009-01-01 00:00:00
abstract：:The introduction of highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus (HIV) infection has significantly improved the life expectancy of HIV positive patients. Hepatitis C virus (HCV) co-infection is common in HIV infected patients and is now a significant cause of morbidity and mortality. ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612043384286
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Cancer and its treatment therapies, such as chemotherapy and radiotherapy, have negative effects on taste and smell functions. It is easy to explain smell and taste dysfunctions when a cancer involves the peripheric end organs or neurologic pathways of smell and taste. However, it is difficult to understand ...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666160216150956
更新日期：2016-01-01 00:00:00
abstract：:In recent years, the simple paradigm of adipose tissue as merely a fat store is rapidly evolving into a complex paradigm of this tissue as multipotential secretory organ, partitioned into a few large depots, including visceral and subcutaneous location, and many small depots, associated with a variety of organs in the...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612033455152
更新日期：2003-01-01 00:00:00
abstract：:ABO-incompatible (ABO-I) liver transplantation (LT) has been limited due to the increased rate of complications, including severe cellular and antibody-mediated rejection, hepatic necrosis, hepatic artery thrombosis, and biliary complications. However, several strategies for reducing preformed anti-donor ABO antibodie...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612826666200506094539
更新日期：2020-01-01 00:00:00
abstract：:The vasoconstrictive and antidiuretic physiologic properties of vasopressin (antidiuretic hormone) have long been known. Until recently however, vasopressin was mostly used for diabetes insipidus and noctournal enuresis. This review summarizes the growing body of evidence regarding the perioperative use of vasopressin...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161212803832326
更新日期：2012-01-01 00:00:00
abstract：:Dioxygen (O2) is an exogenously supplied gas with a number of properties that make it valuable as a biological source of energy and as a result much of life has become dependent on this molecule. Nitric oxide (NO), carbon dioxide (CO) and hydrogen sulfide (H2S) are small molecules that are sometimes in a gaseous state...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161207782110525
更新日期：2007-01-01 00:00:00
abstract：:In recent years, there has been an exciting focus of research attempting to understand neuropsychiatric disorders from a holistic perspective in order to determine the role of gut microbiota in the aetiology and pathogenesis of such disorders. Thus, the possible therapeutic benefits of targeting gut microbiota are bei...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612826666200122153541
更新日期：2020-01-01 00:00:00
abstract：:Despite the significant progresses made in antiretroviral therapy, current drugs still cannot cure or prevent HIV infection. And all drugs continue to select for drug-resistant HIV strains. Consequently, new antiretroviral drugs are constantly being developed. To ensure safety, these drugs are usually designed to inhi...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612043382422
更新日期：2004-01-01 00:00:00
abstract：:Separating emotions from cognition seems impossible in everyday experiences of a human being. Emotional processes have an impact on the ability of planning and solving problems, or decision-making skills. They are a valuable source of information about ourselves, our partners in interactions and the surrounding world....
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/1381612822666151230110738
更新日期：2016-01-01 00:00:00
abstract：:Supraventricular tachycardias (SVTs) are observed in 0,1-0,4% of the paediatric population and represent an important clinical problem with related significant health and social issues. Most tachycardias are paroxysmal, being associated with sudden onset and termination, and only a relatively small number of them is p...
journal_title：Current pharmaceutical design
pub_type： 杂志文章,评审
doi：10.2174/138161208784007761
更新日期：2008-01-01 00:00:00
