Bayesian non-response models for categorical data from small areas: an application to BMD and age.

Abstract:

:We provide a Bayesian analysis of data categorized into two levels of age (younger than 50 years, at least 50 years) and three levels of bone mineral density (normal, osteopenia, osteoporosis) for white females at least 20 years old in the third National Health and Nutrition Examination Survey. For the sample, the age of each individual is known, but some individuals did not have their BMD measured. We use two types of models: In the ignorable non-response models the propensity to respond does not depend on BMD and age of an individual, while in the non-ignorable non-response models it does. These are the baseline models which are used to derive all models for testing. Our non-ignorable non-response models are 'close' to the ignorable non-response models, thereby reducing the effects of the assumptions about non-respondents that cannot be tested in non-response models. We have data from 35 counties, small areas, and therefore our models are hierarchical, a feature that allows a 'borrowing of strength' across the counties, and they provide a substantial reduction in variation. The non-ignorable non-response models are generalizations of the ignorable non-response models, and therefore, the non-ignorable non-response models allow broader inference. The joint posterior density of the parameters for each model is complex, and therefore, we fit each model using Markov chain Monte Carlo methods to obtain samples which are used to make inference about BMD and age. For each county we can estimate the proportion of individuals in each BMD and age cell of the categorical table, and we can assess the relation between BMD and age using the Bayes factor. A sensitivity analysis shows that there are differences (typically small) in inference that permits different levels of association between BMD and age. A simulation study shows that there is not much difference between the baseline ignorable and non-ignorable non-response models.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Nandram B,Liu N,Choi JW,Cox L

doi

10.1002/sim.1985

subject

Has Abstract

pub_date

2005-04-15 00:00:00

pages

1047-74

issue

7

eissn

0277-6715

issn

1097-0258

journal_volume

24

pub_type

杂志文章
  • Outcome-adaptive randomization for a delayed outcome with a short-term predictor: imputation-based designs.

    abstract::Delay in the outcome variable is challenging for outcome-adaptive randomization, as it creates a lag between the number of subjects accrued and the information known at the time of the analysis. Motivated by a real-life pediatric ulcerative colitis trial, we consider a case where a short-term predictor is available fo...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6222

    authors: Kim MO,Liu C,Hu F,Lee JJ

    更新日期:2014-10-15 00:00:00

  • An analysis of disease surveillance data that uses the geographic locations of the reporting units.

    abstract::The primary purpose of a disease surveillance system is to provide data for the detection of changes in the incidence of the disease. Methods for the analysis of data from surveillance systems are reviewed. A new procedure is proposed for use when the system includes geographically dispersed reporting units, such as h...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780080306

    authors: Raubertas RF

    更新日期:1989-03-01 00:00:00

  • Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables.

    abstract::Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic mar...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3843

    authors: Burgess S,Thompson SG,CRP CHD Genetics Collaboration.,Burgess S,Thompson SG,Andrews G,Samani NJ,Hall A,Whincup P,Morris R,Lawlor DA,Davey Smith G,Timpson N,Ebrahim S,Ben-Shlomo Y,Davey Smith G,Timpson N,Brown M,Ricket

    更新日期:2010-05-30 00:00:00

  • A new proposal to adjust Moran's I for population density.

    abstract::We analyse the effect of using prevalence rates based on populations with different sizes in the power of spatial independence tests. We compare the well known spatial correlation Moran's index to three indexes obtained after adjusting for population density, one proposed by Oden, another proposed by Waldhör, and a th...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0258(19990830)18:16<2147::aid-s

    authors: Assunção RM,Reis EA

    更新日期:1999-08-30 00:00:00

  • Assessment of postpartum time-dependent disease risk in case-control studies: an application for examining age-specific effect estimates.

    abstract::Among subjects who have experienced a biological event, such as menarche, menopause or a delivery, one cannot distinguish the effects of time since the event from age at the event due to the linear dependency among these time variables and age at study ('current age'). This is a well-known problem that also exists in ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0258(19960730)15:14<1545::AID-S

    authors: Hsieh CC,Lan SJ

    更新日期:1996-07-30 00:00:00

  • REML and ML estimation for clustered grouped survival data.

    abstract::Clustered grouped survival data arise naturally in clinical medicine and biological research. For example, in a randomized clinical trial, the variable of interest is the time to occurrence of a certain event with or without a new treatment and the data are collected from possibly correlated subjects from independent ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1323

    authors: Lam KF,Ip D

    更新日期:2003-06-30 00:00:00

  • Model-based multiplicity estimation of population size.

    abstract::A survey is conducted at w of K selection units or lists, e.g. health care institutions or weeks in a year, to estimate N, the total number of individuals with particular characteristics. Our estimator utilizes two items determined for each survey participant: the number, u, among the w lists in S and the number, j, a...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3614

    authors: Laska EM,Meisner M,Wanderling J

    更新日期:2009-07-30 00:00:00

  • A small sample study of the STEPP approach to assessing treatment-covariate interactions in survival data.

    abstract::A new, intuitive method has recently been proposed to explore treatment-covariate interactions in survival data arising from two treatment arms of a clinical trial. The method is based on constructing overlapping subpopulations of patients with respect to one (or more) covariates of interest and in observing the patte...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3524

    authors: Bonetti M,Zahrieh D,Cole BF,Gelber RD

    更新日期:2009-04-15 00:00:00

  • Non-parametric methods for recurrent event data with informative and non-informative censorings.

    abstract::Recurrent event data are commonly encountered in health-related longitudinal studies. In this paper time-to-events models for recurrent event data are studied with non-informative and informative censorings. In statistical literature, the risk set methods have been confirmed to serve as an appropriate and efficient ap...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1029

    authors: Wang MC,Chiang CT

    更新日期:2002-02-15 00:00:00

  • A new approach to training back-propagation artificial neural networks: empirical evaluation on ten data sets from clinical studies.

    abstract::We present a new approach to training back-propagation artificial neural nets (BP-ANN) based on regularization and cross-validation and on initialization by a logistic regression (LR) model. The new approach is expected to produce a BP-ANN predictor at least as good as the LR-based one. We have applied the approach to...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1107

    authors: Ciampi A,Zhang F

    更新日期:2002-05-15 00:00:00

  • Estimation of infection prevalence and sensitivity in a stratified two-stage sampling design employing highly specific diagnostic tests when there is no gold standard.

    abstract::In this work, we describe a two-stage sampling design to estimate the infection prevalence in a population. In the first stage, an imperfect diagnostic test was performed on a random sample of the population. In the second stage, a different imperfect test was performed in a stratified random sample of the first sampl...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6545

    authors: Miller E,Huppert A,Novikov I,Warburg A,Hailu A,Abbasi I,Freedman LS

    更新日期:2015-11-10 00:00:00

  • Discriminant analysis using a multivariate linear mixed model with a normal mixture in the random effects distribution.

    abstract::We have developed a method to longitudinally classify subjects into two or more prognostic groups using longitudinally observed values of markers related to the prognosis. We assume the availability of a training data set where the subjects' allocation into the prognostic group is known. The proposed method proceeds i...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3849

    authors: Komárek A,Hansen BE,Kuiper EM,van Buuren HR,Lesaffre E

    更新日期:2010-12-30 00:00:00

  • A simple correction for ties when censoring times depend on covariates.

    abstract::We point out that the conventional methods for ties correction may be seriously biased when censoring times depend on covariates. A simple modification to the Efron correction method is suggested which works remarkably well in simulation studies. The method corresponds closely to breaking ties by random ordering. The ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.2173

    authors: Samuelsen SO,Wisløff TF,Skrondal A

    更新日期:2005-10-30 00:00:00

  • Adaptive prior variance calibration in the Bayesian continual reassessment method.

    abstract::The use of the continual reassessment method (CRM) and other model-based approaches to design Phase I clinical trials has increased owing to the ability of the CRM to identify the maximum tolerated dose better than the 3 + 3 method. However, the CRM can be sensitive to the variance selected for the prior distribution ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.5621

    authors: Zhang J,Braun TM,Taylor JM

    更新日期:2013-06-15 00:00:00

  • A non-parametric approach to the design and analysis of two-dimensional dose-finding trials.

    abstract::This paper investigates the design and analysis of dose-finding trials with two agents. The set of doses for each agent is fixed in advance. The goal of the trial is to find the set of dose combinations with probability of toxicity closest to a pre-specified value. For each of the two agents we assume that the probabi...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1796

    authors: Ivanova A,Wang K

    更新日期:2004-06-30 00:00:00

  • Performance assessment for radiologists interpreting screening mammography.

    abstract::When interpreting screening mammograms radiologists decide whether suspicious abnormalities exist that warrant the recall of the patient for further testing. Previous work has found significant differences in interpretation among radiologists; their false-positive and false-negative rates have been shown to vary widel...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.2633

    authors: Woodard DB,Gelfand AE,Barlow WE,Elmore JG

    更新日期:2007-03-30 00:00:00

  • Estimation of gene-environment interaction by pooling biospecimens.

    abstract::Case-control studies are prone to low power for testing gene-environment interactions (GXE) given the need for a sufficient number of individuals on each strata of disease, gene, and environment. We propose a new study design to increase power by strategically pooling biospecimens. Pooling biospecimens allows us to in...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.5357

    authors: Danaher MR,Schisterman EF,Roy A,Albert PS

    更新日期:2012-11-20 00:00:00

  • Analyzing longitudinal data to characterize the accuracy of markers used to select treatment.

    abstract::With the increasing availability of detailed clinical information, there is optimism that treatment choices can be selectively directed to those individuals most likely to benefit. While standard clinical trials can establish whether a treatment appears to be effective on average, subsequent work is needed to determin...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.6138

    authors: Sitlani CM,Heagerty PJ

    更新日期:2014-07-30 00:00:00

  • Current development in clinical trials: issues old and new.

    abstract::Clinical trials, especially the randomized clinical trial, have been and will remain the gold standard for the evaluation of new interventions, including pharmaceuticals, biologics, medical devices, procedures, or behavioral modifications. Despite more than five decades of experience, there are still challenges in the...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.5405

    authors: DeMets DL

    更新日期:2012-11-10 00:00:00

  • Sequential designs for phase III clinical trials incorporating treatment selection.

    abstract::Most statistical methodology for phase III clinical trials focuses on the comparison of a single experimental treatment with a control. An increasing desire to reduce the time before regulatory approval of a new drug is sought has led to development of two-stage or sequential designs for trials that combine the defini...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.1362

    authors: Stallard N,Todd S

    更新日期:2003-03-15 00:00:00

  • Robustness of the two independent samples t-test when applied to ordinal scaled data.

    abstract::One may encounter the application of the two independent samples t-test to ordinal scaled data (for example, data that assume only the values 0, 1, 2, 3) from small samples. This situation clearly violates the underlying normality assumption for the t-test and one cannot appeal to large sample theory for validity. In ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780060110

    authors: Heeren T,D'Agostino R

    更新日期:1987-01-01 00:00:00

  • The SAEM algorithm for group comparison tests in longitudinal data analysis based on non-linear mixed-effects model.

    abstract::Non-linear mixed-effects models (NLMEMs) are used to improve information gathering from longitudinal studies and are applied to treatment evaluation in disease-evolution studies, such as human immunodeficiency virus (HIV) infection. The estimation of parameters and the statistical tests are critical issues in NLMEMs s...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.2950

    authors: Samson A,Lavielle M,Mentré F

    更新日期:2007-11-30 00:00:00

  • Some considerations in the analysis of rates of change in longitudinal studies.

    abstract::This paper discusses and compares several estimators of mean rate of change in unbalanced longitudinal data based on a model with randomly distributed regression coefficients across individuals. The estimators are unweighted and weighted means of these coefficients. The paper also evaluates commonly used variance esti...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.4780060509

    authors: Palta M,Cook T

    更新日期:1987-07-01 00:00:00

  • Simultaneous modelling of operative mortality and long-term survival after coronary artery bypass surgery.

    abstract::Typical analyses of lifetime data treat the time to death or failure as the response variable and use a variety of modelling strategies such as proportional hazards or fully parametric, to investigate the relationship between the response and covariates. In certain circumstances it may be more natural to view the dist...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.822

    authors: Ghahramani M,Dean CB,Spinelli JJ

    更新日期:2001-07-15 00:00:00

  • Comparison of predictive values of two diagnostic tests from the same sample of subjects using weighted least squares.

    abstract::Screening and diagnostic tests are important in disease prevention or control. The predictive values of positive and negative (PPV and NPV) test results are two of four operational characteristics of a screening test. We review an existing method based on the generalized estimating equation (GEE) methodology for compa...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.2332

    authors: Wang W,Davis CS,Soong SJ

    更新日期:2006-07-15 00:00:00

  • Baseline risk as predictor of treatment benefit: three clinical meta-re-analyses.

    abstract::A relationship between baseline risk and treatment effect is increasingly investigated as a possible explanation of between-study heterogeneity in clinical trial meta-analysis. An approach that is still often applied in the medical literature is to plot the estimated treatment effects against the estimated measures of...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/1097-0258(20001230)19:24<3497::aid-sim830>

    authors: Arends LR,Hoes AW,Lubsen J,Grobbee DE,Stijnen T

    更新日期:2000-12-30 00:00:00

  • Estimation methods for marginal and association parameters for longitudinal binary data with nonignorable missing observations.

    abstract::In longitudinal studies, missing observations occur commonly. It has been well known that biased results could be produced if missingness is not properly handled in the analysis. Authors have developed many methods with the focus on either incomplete response or missing covariate observations, but rarely on both. The ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.5536

    authors: Li H,Yi GY

    更新日期:2013-02-28 00:00:00

  • Quantifying the bias due to observed individual confounders in causal treatment effect estimates.

    abstract::It is often of interest to use observational data to estimate the causal effect of a target exposure or treatment on an outcome. When estimating the treatment effect, it is essential to appropriately adjust for selection bias due to observed confounders using, for example, propensity score weighting. Selection bias du...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.8549

    authors: Parast L,Griffin BA

    更新日期:2020-08-15 00:00:00

  • Multilevel modeling versus cross-sectional analysis for assessing the longitudinal tracking of cardiovascular risk factors over time.

    abstract::Correlated data are obtained in longitudinal epidemiological studies, where repeated measurements are taken on individuals or groups over time. Such longitudinal data are ideally analyzed using multilevel modeling approaches, which appropriately account for the correlations in repeated responses in the same individual...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.5880

    authors: Xanthakis V,Sullivan LM,Vasan RS

    更新日期:2013-12-10 00:00:00

  • Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis.

    abstract::Genetic networks for gene expression data are often built by graphical models, which in turn are built from pair-wise correlations of gene expression levels. A key feature of building graphical models is the evaluation of conditional independence of two traits, given other traits. When conditional independence can be ...

    journal_title:Statistics in medicine

    pub_type: 杂志文章

    doi:10.1002/sim.3274

    authors: Yu Z,Wang L,Hildebrandt MA,Schaid DJ

    更新日期:2008-08-30 00:00:00