The ketogenic diet does not alter brain expression of orexigenic neuropeptides.

Abstract:

:Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD.

journal_name

Epilepsy Res

journal_title

Epilepsy research

authors

Tabb K,Szot P,White SS,Liles LC,Weinshenker D

doi

10.1016/j.eplepsyres.2004.08.002

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

35-9

issue

1

eissn

0920-1211

issn

1872-6844

pii

S0920-1211(04)00151-2

journal_volume

62

pub_type

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