Abstract:
BACKGROUND:Cutaneous leishmaniasis is a common disease in Iran, especially in the north-east, central and southern parts of the country. Many treatments have been suggested for this disease but none is completely effective and without side-effects such as pain, arthralgia and renal or cardiac complications. Lasers have been used for treatment of several skin diseases since 1970, and CO(2) lasers are now being used for treatment of leishmaniasis. In this study, a CO(2) laser (Sonic 500 machine) was used as a source of a continuous CO(2) laser wave. METHODS:A total of 123 patients (68 female and 55 male) with 183 lesions were treated with the CO(2) laser. The maximum power was 100 W and the pulse width was 0.5-5 s. For the control group, 110 patients (with 250 lesions) were treated with glucantime 50 mg/kg/day for 15 days and, after 15 days of rest, this treatment was repeated (Glucantime Amps, 1.5 g in a 50-mL solution, was used). For follow-up, the patients were visited 1, 3, 4, 8, 12 and 24 weeks after treatment and any complications, recurrences or other wound characteristics were recorded. In the second group, Finally, all collected data were analyzed statistically. RESULTS:Statistical analysis with the chi(2) test showed that treatment with the CO(2) laser was more effective than treatment with glucantime (P = 0.0007). Complications were also seen less often with the laser treatment than with glucantime and were limited to the ulcer site. The CO(2) laser was more effective in treating cutaneous leishmaniasis than glucantime (1.12 times), had fewer side-effects (4.5% vs. 24%) and resulted in a shorter healing time (1 month vs. 3 months), and treatment could be applied in a single session. CONCLUSIONS:The results of this and previous studies suggest that cutaneous leishmaniasis can be treated effectively with CO(2) laser if those providing the treatment are sufficiently experienced. Laser treatment is more cost-effective than other treatments and can be used as first-line therapy for cutaneous leishmaniasis (wet and dry types).
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Asilian A,Sharif A,Faghihi G,Enshaeieh Sh,Shariati F,Siadat AHdoi
10.1111/j.1365-4632.2004.02349.xsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
736-8issue
10eissn
0011-9059issn
1365-4632pii
IJD2349journal_volume
43pub_type
临床试验,杂志文章abstract:BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05408.x
更新日期:2013-06-01 00:00:00
abstract::Three proven cases of bullous pemphigoid in childhood which responded to dapsone are reported. The clinical and immunological criteria for diagnosis were similar to those in the aged. This report emphasizes that the condition is a distinctive clinical entity and entirely different from dermatitis herpetiformis and ben...
journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1977.tb01841.x
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abstract::Based on a study of 400 patients (272 patients with herpes zoster and 128 with postzoster neuralgia), the subcutaneous injection of triamcinolone in saline is concluded to be a safe and effective measure for reducing pain. The acute eruption and symptoms of herpes zoster cleared in an average of less than four days. P...
journal_title:International journal of dermatology
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更新日期:1981-01-01 00:00:00
abstract:BACKGROUND AND DESIGN:The clinical, histologic, and direct (DIF) and indirect (IIF) immunofluorescence findings are used in a critical, although arbitrary, manner in the routine diagnostic process of bullous pemphigoid (BP). Our purpose was to estimate their relative value. In the present retrospective study, a follow-...
journal_title:International journal of dermatology
pub_type: 杂志文章
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abstract:BACKGROUND:Vitiligo is a common idiopathic skin disorder. The etiology is unknown, although various hypotheses have been advanced. These include the neuronal hypothesis, where neuronal factors are thought to play a role in the pathogenesis of this disease. METHODS:Skin biopsies were taken from marginal and central par...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04417.x
更新日期:1995-12-01 00:00:00
abstract::Several economic factors are forcing changes in the American health care system. Many of these future changes will be implemented by the government. If left unguided, the governmental agencies could regulate doctors' practices, duties, and fees and place them in a bureaucratic maze. The cost of these changes to societ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1985.tb05763.x
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abstract:BACKGROUND:Mycosis fungoides (MF) is an indolent, most common type of cutaneous T-cell lymphoma (CTCL) with an average estimated incidence of 0.5 cases per 100,000 persons per year in the western world. Although various clinical and epidemiological features are well delineated in the western population, the data is sca...
journal_title:International journal of dermatology
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doi:10.1111/j.1365-4632.2010.04567.x
更新日期:2010-12-01 00:00:00
abstract::Pregnancy causes some physiological skin changes, such as hyperpigmentation and striae gravidarum. Thickening of scalp hair and a prolonged anagen phase are also known to occur during pregnancy. However, a limited number of studies have been conducted on the effect of pregnancy on the nails. We aimed to investigate th...
journal_title:International journal of dermatology
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abstract::The antimicrobial activity of gentian violet and brilliant green was tested against various strains of potential skin pathogens, by means of agar diffusion assay. The activity of both compounds was affected by pH. Gentian violet was found to be more active than brilliant green at pH 7.4, particularly against Pseudomon...
journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1992.tb03939.x
更新日期:1992-03-01 00:00:00
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journal_title:International journal of dermatology
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abstract::Aquatic dermatoses encompass a broad spectrum of cutaneous injuries. These injuries may present through contact with invertebrate organisms such as jellyfish, sea urchins, corals, and molluscs. Each organism is equipped with a unique method of causing harm to man, therefore a myriad of presenting signs and symptoms sh...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02919.x
更新日期:2006-12-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02109.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To report three cases of mycosis fungoides with milia formation in the regressing lesions. PATIENTS AND SETTING:Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (sta...
journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02423.x
更新日期:1988-11-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-12-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
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更新日期:1994-08-01 00:00:00
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