Attitudes and beliefs concerning prostate cancer genetic screening.

Abstract:

:This quantitative study determines the values, beliefs, and attitudes influencing the intention of men to undergo or defer genetic testing for prostate cancer risk using a model based on components of the Theory of Reasoned Action and Health Belief Model. Telephone interviews of a community sample of 400 men in a large, East Coast metropolitan area of diverse educational, ethnic, and age backgrounds were conducted to rank key values and beliefs about genetic testing for prostate cancer risk in anticipation of its future availability. Descriptive statistics, univariate analyses, and logistic regression were used in data analysis. The factors of values attached to consequences, motivation from self, beliefs in benefits, and a motivation to comply with others (borderline) were statistically significant for testing intention. Of all demographics, only increased education was associated with diminished interest in testing. Desire to be tested varied widely across groups of men. Based on these identified values, health professionals can better understand men's values and beliefs on the risks and benefits of testing. The relationship of men to others, family and society, require further investigation in this and other aspects of genetic testing.

journal_name

Clin Genet

journal_title

Clinical genetics

authors

Doukas DJ,Localio AR,Li Y

doi

10.1111/j.1399-0004.2004.00305.x

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

445-51

issue

5

eissn

0009-9163

issn

1399-0004

pii

CGE305

journal_volume

66

pub_type

杂志文章
  • Mental retardation, short stature, minor skeletal anomalies, craniofacial dysmorphism and macrodontia in two sisters and their mother. Another variant example of the KBG syndrome?

    abstract::Mental retardation associated with short stature, craniofacial dysmorphism, macrodontia and minor skeletal anomalies is reported in two sisters and their mother. The similarity with and the relationship to the KBG syndrome is discussed and the importance of clinical syndrome identification in familial mental retardati...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1984.tb00792.x

    authors: Fryns JP,Haspeslagh M

    更新日期:1984-07-01 00:00:00

  • Early childhood development of four boys with 47, XXY karyotype.

    abstract::In an epidemiological study, infants identified at birth as having sex chromosome anomalies are enrolled in a voluntary, long term evaluations program. Case histories are presented of the first four boys in the series to have a 47,XXY karyotype. They have been followed from birth for 6 to 9 years, with physical and ps...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1975.tb00357.x

    authors: Puck M,Tennes K,Frankenburg W,Bryant K,Robinson A

    更新日期:1975-01-01 00:00:00

  • Severe congenital encephalopathy caused by MECP2 null mutations in males: central hypoxia and reduced neuronal dendritic structure.

    abstract::Non-mosaic males with a 46,XY karyotype and a MECP2 null mutation display a phenotype of severe neonatal-onset encephalopathy that is distinctly different from Rett syndrome (RTT). To increase awareness of this rare disorder, we are reporting novel findings in a sporadic case, compare them to 16 previously reported ca...

    journal_title:Clinical genetics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0004.2008.01005.x

    authors: Schüle B,Armstrong DD,Vogel H,Oviedo A,Francke U

    更新日期:2008-08-01 00:00:00

  • Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia.

    abstract::Lee S-C, Guo J-Y, Lim R, Soo R, Koay E, Salto-Tellez M, Leong A, Goh B-C. Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. Hereditary non-polyposis colorectal cancer (HNPCC), predominantly due to germline MLH1/MSH2 mutations, is the commonest form of here...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2005.00469.x

    authors: Lee SC,Guo JY,Lim R,Soo R,Koay E,Salto-Tellez M,Leong A,Goh BC

    更新日期:2005-08-01 00:00:00

  • Development and disease of the photoreceptor cilium.

    abstract::Primary cilia are microtubule-rich hair-like extensions protruding from the surface of most post-mitotic cells. They act as sensory organelles that help interpret various environmental cues. Mutations in genes encoding proteins involved in ciliogenesis or protein transport to the primary cilia lead to a wide variety o...

    journal_title:Clinical genetics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0004.2009.01240.x

    authors: Ramamurthy V,Cayouette M

    更新日期:2009-08-01 00:00:00

  • Deletions, duplications and novel restriction fragment length polymorphism in Duchenne and Becker muscular dystrophies.

    abstract::To determine the mutations of Southern Chinese with Duchenne and Becker muscular dystrophies (DMD, BMD), we analysed 28 DMD and BMD patients in 24 unrelated families for intragenic deletions and duplications by using cDNA probes covering the entire 14 kb of the dystrophin gene. Deletions were detected in nine unrelate...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1992.tb03676.x

    authors: Lau YL,Srivastava G,Wong V,Liu YT,Ho FC,Yeung CY

    更新日期:1992-05-01 00:00:00

  • Little phenotypic variability in three CF sibs compound heterozygous for the 621 + 1G-->T and the 711 + 1G-->T mutations.

    abstract::We describe a family in which three sibs are compound heterozygotes for two rather rare CFTR splice-site mutations, the 621 + 1G-->T and the 711 + 1G-->T mutations. Little phenotypic variation was observed between sibs, of whom two are deceased. Their disease is characterized by pancreatic insufficiency, a severe pulm...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1997.tb02456.x

    authors: De Braekeleer M,Simard F,Aubin G

    更新日期:1997-03-01 00:00:00

  • Mining for mitochondrial mechanisms: Linking known syndromes to mitochondrial function.

    abstract::Mitochondrial disorders (MDs) are caused by defects in 1 or multiple complexes of the oxidative phosphorylation (OXPHOS) machinery. MDs are associated with a broad range of clinical signs and symptoms, and have considerable clinical overlap with other neuromuscular syndromes. This overlap might be due to involvement o...

    journal_title:Clinical genetics

    pub_type: 杂志文章,评审

    doi:10.1111/cge.13094

    authors: Panneman DM,Smeitink JA,Rodenburg RJ

    更新日期:2018-05-01 00:00:00

  • Usefulness of a registry of congenital malformations for genetic counseling and prenatal diagnosis.

    abstract::During three years, 39,924 infants born consecutively in the area covered by our registry of congenital malformations were surveyed; 775 had major congenital malformations. Recurrence risks for the major malformation was estimated and classified as high (greater than 10%, 5.3% of the cases), low (1 to 10%, 85.3% of th...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1986.tb00813.x

    authors: Stoll C,Roth MP,Dott B,Bigel P

    更新日期:1986-03-01 00:00:00

  • Factors that affect hearing level in individuals with the mitochondrial 1555A.G mutation.

    abstract::The mitochondrial 1555A>G mutation is one of the most common mutations responsible for hearing loss in Asians. Although the association with aminoglycoside exposure is well known, there is great variation in the severity of hearing loss. We analyzed hearing levels in 221 Japanese individuals with this mutation and att...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2008.01138.x

    authors: Lu SY,Nishio S,Tsukada K,Oguchi T,Kobayashi K,Abe S,Usami S

    更新日期:2009-05-01 00:00:00

  • Parental origin of apparently balanced de novo complex chromosomal rearrangements investigated by microdissection, whole genome amplification, and microsatellite-mediated haplotype analysis.

    abstract::Complex chromosomal rearrangements (CCRs) are rare findings in clinical cytogenetics. As a result of the high risk of unbalanced segregation, familial cases are even rarer and maternal transmission occurs more frequently than paternal transmission. Analogous to Drosophila and mice, as well as to CCRs involving the Y c...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2010.01419.x

    authors: Grossmann V,Höckner M,Karmous-Benailly H,Liang D,Puttinger R,Quadrelli R,Röthlisberger B,Huber A,Wu L,Spreiz A,Fauth C,Erdel M,Zschocke J,Utermann G,Kotzot D

    更新日期:2010-12-01 00:00:00

  • Partial deletion of long arm of chromosome 11: del (11) (q23).

    abstract::The cytogenetic analysis of an infant with multiple congenital anomalies revealed a small deletion of the long arm of one No. 11 chromosome: 46,XX,del(11)(q23). The main clinical manifestations included: ocular colobomata, absent philtrum, severe congenital heart disease, contractures of the large joints and skin pigm...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1977.tb00950.x

    authors: Kaffe S,Hsu LY,Sachdev RK,Philips J,Hirschhorn K

    更新日期:1977-12-01 00:00:00

  • Cutis laxa: autosomal dominant inheritance in five generations.

    abstract::Cutis laxa is described in three cases: a 17-year-old man, his mother and his maternal grandmother. The onset of skin symptoms occurred from puberty to early adulthood. The skin was loose-hanging, wrinkled and without elasticity. X-ray examination showed numerous gastrointestinal diverticulae in the two older patients...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1991.tb03038.x

    authors: Damkier A,Brandrup F,Starklint H

    更新日期:1991-05-01 00:00:00

  • Cord blood immunoglobulin E in like-sexed monozygotic and dizygotic twins.

    abstract::Genetic and environmental factors have been implicated in the etiology of atopy and of serum IgE levels. In order to eliminate post-natal environmental influences we measured IgE in cord blood (CB-IgE) from a cohort of unselected, like-sexed twins. IgE determination was performed with a sensitive radioimmunoassay with...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1996.tb02384.x

    authors: Husby S,Holm NV,Christensen K,Skov R,Morling N,Petersen PH

    更新日期:1996-11-01 00:00:00

  • Multiple sequence variations in SLC5A1 gene are associated with glucose-galactose malabsorption in a large cohort of Old Order Amish.

    abstract::Glucose-galactose malabsorption (GGM) is an autosomal recessive disease with life-threatening newborn diarrhea caused by mutations in the Na(+) /glucose cotransporter gene SLC5A1. Because of its rarity, the clinical course of the disease has not been well studied. Here, we report 33 patients with GGM from a large Old ...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2010.01440.x

    authors: Xin B,Wang H

    更新日期:2011-01-01 00:00:00

  • Structure, origin and effects of a supernumerary marker chromosome 15.

    abstract::A de novo supernumerary small marker chromosome 15 was observed in a female infant with mental and statomotoric retardation as well as minor facial dysmorphia. The marker chromosome was analyzed by ten different staining techniques and 5-azacytidine treatment of lymphocyte cultures. It is shown that the supernumerary ...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1986.tb00570.x

    authors: Schmid M,Schindler D,Haaf T

    更新日期:1986-07-01 00:00:00

  • Exploring the utility of whole-exome sequencing as a diagnostic tool in a child with atypical episodic muscle weakness.

    abstract::The advent of whole-exome next-generation sequencing (WES) has been pivotal for the molecular characterization of Mendelian disease; however, the clinical applicability of WES has remained relatively unexplored. We describe our exploration of WES as a diagnostic tool in a 3½-year old female patient with a 2-year histo...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2012.01951.x

    authors: Hanchard NA,Murdock DR,Magoulas PL,Bainbridge M,Muzny D,Wu Y,Wang M,Lupski JR,Gibbs RA,Brown CW

    更新日期:2013-05-01 00:00:00

  • A novel monogenic preimplantation genetic testing strategy for sporadic polycystic kidney caused by de novo PKD1 mutation.

    abstract::Autosomal dominant hereditary polycystic kidney disease (ADPKD) is the most common inherited kidney disease that causes end-stage renal disease and kidney failure. Preimplantation genetic testing for monogenic (PGT-M) can effectively prevent the transmission of genetic diseases from parents to the offspring before pre...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/cge.13871

    authors: Shi H,Niu W,Liu Y,Jin H,Song W,Shi S,Yao G,Xu J,Sun Y

    更新日期:2021-02-01 00:00:00

  • Genetic counselling in hypomelanosis of Ito: case report and review.

    abstract::A 27-year-old male with hypomelanosis of Ito (HI) is reported. One of his two children had a postaxial ray defect of one leg but neither had cutaneous features of HI. Somatic mosaicism for a gene defect lethal to ectodermal derivatives offers the best explanation for HI in males, with consequent negligible recurrence ...

    journal_title:Clinical genetics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-0004.1988.tb02845.x

    authors: Moss C,Burn J

    更新日期:1988-08-01 00:00:00

  • Congenital hypoparathyroidism, seizure, extreme growth failure with developmental delay and dysmorphic features--another case of this new syndrome.

    abstract::A 4-year-old Saudi female child with extreme failure to thrive, striking dysmorphic features, developmental delay, congenital hypoparathyroidism, UTI, seizures, chronic otitis media, chronic non-specific gastroenteritis and repeated life-threatening infections was followed from birth. She was the product of first-cous...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1992.tb03220.x

    authors: Kalam MA,Hafeez W

    更新日期:1992-09-01 00:00:00

  • Young people's experiences of growing up in a family affected by Huntington's disease.

    abstract::Previous research and clinical experience suggest that Huntington's disease (HD) can considerably affect family life, particularly for young people (YP) at risk. The goal of this study was to describe the experiences of YP from families affected by HD. YP were identified through the regional genetics clinic and the Sc...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2006.00702.x

    authors: Forrest Keenan K,Miedzybrodzka Z,van Teijlingen E,McKee L,Simpson SA

    更新日期:2007-02-01 00:00:00

  • Comorbidity in the Tunisian population.

    abstract::Genetic diseases in the Tunisian population represent a real problem of public health as their spectrum encompasses more than 400 disorders. Their frequency and distribution in the country have been influenced by demographic, economic and social features especially consanguinity. In this article, we report on genetic ...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/cge.12616

    authors: Romdhane L,Messaoud O,Bouyacoub Y,Kerkeni E,Naouali C,Cherif Ben Abdallah L,Tiar A,Charfeddine C,Monastiri K,Chabchoub I,Hachicha M,Tadmouri GO,Romeo G,Abdelhak S

    更新日期:2016-03-01 00:00:00

  • A paternally inherited non-sense variant c.424G>T (p.G142*) in the first exon of XLαs in an adult patient with hypophosphatemia and osteopetrosis.

    abstract::XLαs, the extra-large isoform of alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gsα), is paternally expressed. The significance of XLαs in humans remains largely unknown. Here, we report a patient who presented with increased bone mass, hypophosphatemia, and elevated parathyroid hormone (PTH) lev...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/cge.13734

    authors: Chen X,Meng Y,Tang M,Wang Y,Xie Y,Wan S,Tian H,Yu X

    更新日期:2020-05-01 00:00:00

  • Late-onset familial amyloid polyneuropathy with the TTR Met 30 mutation in France.

    abstract::Four unrelated French cases of familial amyloid polyneuropathy are reported. Clinical onset ranged from the sixth to the ninth decade. Sensory signs were predominant initially in the lower limbs; motor changes, and in one case autonomic involvement, appeared later. Amyloid disease was clinically limited to the periphe...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1993.tb04439.x

    authors: Grateau G,Adams D,Malapert D,Viemont M,Delpech M,Said G

    更新日期:1993-03-01 00:00:00

  • Ring chromosome 13 syndrome.

    abstract::A girl in whom a ring chromosome 13 was found, presented with microcephaly, mental retardation and multiple minor malformations. She was born after a full term pregnancy, small for date and with a small head circumference. She underwent craniotomy at the age of 18 months because of premature closure of the metopic sut...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1975.tb00320.x

    authors: Fried K,Rosenblatt M,Mundel G,Krikler R

    更新日期:1975-03-01 00:00:00

  • Retinoblastoma-a clinical survey and its genetic implications.

    abstract::A clinical, pathological and genetic study was made of 50 patients with retinoblastoma in the Newcastle Hospital region over the period 1931-1970 inclusive. Twenty-seven patients were affected in one eye only; 23 had bilateral tumours. The incidence of the tumour was approximately 1:16,000 live births. Bilateral cases...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1975.tb01503.x

    authors: Aherne GE,Roberts DF

    更新日期:1975-10-01 00:00:00

  • Low arylsulphatase A activity in a family without metachromatic leukodystrophy.

    abstract::A low arylsulphatase A activity was noted in the leukocytes and cultured skin fibroblasts of a child without any other symptoms of metachromatic leukodystrophy. Although the mother had a level of arylsulphatase commensurate with heterozygosity for the classical metachromatic leukodystrophy gene, the father had a vari...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1978.tb02133.x

    authors: Butterworth J,Broadhead DM,Keay AJ

    更新日期:1978-10-01 00:00:00

  • Serum lipoprotein(a) levels in elderly black and white men in the Charleston Heart Study.

    abstract::Lipoprotein(a) [Lp(a)] is an important genetic trait associated with cardiovascular disease. While Lp(a) levels have been demonstrated to be approximately twice as high in black adults and children compared with whites, this relationship has not been assessed in the elderly. During the 1987 recall of the Charleston He...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1993.tb03887.x

    authors: Knapp RG,Schreiner PJ,Sutherland SE,Keil JE,Gilbert GE,Klein RL,Hames C,Tyroler HA

    更新日期:1993-11-01 00:00:00

  • A case report of 46,XX,del(21)(q22) de novo deletion associated with Imerslund-Grasbeck syndrome.

    abstract::We describe a 2-year-old female patient who had megaloblastic anaemia caused by selective vitamin B12 malabsorption (Imerslund-Grasbeck syndrome) and del(21)(q22). To our knowledge, this is the first observation of Imerslund-Grasbeck syndrome associated with del(21)(q22) in the literature. ...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.1996.tb02637.x

    authors: Celep F,Karagüzel A,Aynaci FM,Erduran E

    更新日期:1996-10-01 00:00:00

  • Evidence for disease penetrance relating to CNV size: Pelizaeus-Merzbacher disease and manifesting carriers with a familial 11 Mb duplication at Xq22.

    abstract::The potential causes for the incomplete penetrance of Pelizaeus-Merzbacher disease (PMD) in female carriers of PLP1 mutations are not well understood. We present a family with a boy having PMD in association with PLP1 duplication and three females who are apparent manifesting carriers. Custom high-resolution oligonucl...

    journal_title:Clinical genetics

    pub_type: 杂志文章

    doi:10.1111/j.1399-0004.2011.01716.x

    authors: Carvalho CM,Bartnik M,Pehlivan D,Fang P,Shen J,Lupski JR

    更新日期:2012-06-01 00:00:00