Abstract:
OBJECTIVE:To investigate how exercise training and detraining affect oxidized low-density lipoprotein (Ox-LDL)-potentiated platelet function in men. DESIGN:Cohort study. SETTING:Department of physical medicine and rehabilitation. PARTICIPANTS:Ten sedentary men (mean age +/- standard error of the mean, 21.6+/-0.2 y) who did not engage in any regular physical activity for at least 1 year before the study. INTERVENTIONS:Subjects cycled on an ergometer at about 50% of maximal oxygen consumption for 30 minutes daily, 5 days a week, for 8 weeks, then detrained for 12 weeks. MAIN OUTCOME MEASURES:During the experimental period, blood samples from the subjects were collected before and immediately after a progressive exercise test (ie, strenuous, acute exercise) every 4 weeks. The following measurements were taken when the subjects were at rest and immediately after exercise: plasma lipid profile, plasma Ox-LDL level, and platelet aggregation and intracellular calcium concentration ([Ca2+]i) elevation induced by adenosine disphosphate (ADP) alone or simultaneous ADP and Ox-LDL addition. RESULTS:Analytical results indicated that: (1) plasma total cholesterol and LDL levels were reduced after exercise training from 151+/-7 mg/dL and 58+/-2 mg/dL to 133+/-6 mg/dL and 46+/-2 mg/dL (P<.05), respectively, whereas the plasma Ox-LDL level remained unchanged; (2) platelet aggregation and [Ca2+]i elevation promoted by 100 microg/mL of Ox-LDL were significantly increased from 70%+/-5% and 91%+/-7% of resting level to 108%+/-4% and 125%+/-3% after strenuous, acute exercise (P<.05); (3) exercise training decreased resting and postexercise 100 microg/mL Ox-LDL-potentiated platelet aggregation (ie, 31%+/-4% and 82%+/-4%, respectively; P<.05) and [Ca2+]i elevation (ie, 35%+/-6% and 71%+/-4%, respectively; P<.05); (4) detraining reversed the training effects on lipid profile and platelet function; and (5) treating the platelet with L-arginine-inhibited Ox-LDL-potentiated platelet activation during the experimental period. CONCLUSIONS:Our results suggest that 8 weeks of exercise training decreased the plasma LDL level, but failed to influence production of plasma Ox-LDL. Importantly, resting and exercise-induced Ox-LDL-potentiated platelet activation was decreased by exercise training. However, this was reversed by detraining to the pretraining level.
journal_name
Arch Phys Med Rehabiljournal_title
Archives of physical medicine and rehabilitationauthors
Wang JS,Chow SEdoi
10.1016/j.apmr.2003.08.112subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1531-7issue
9eissn
0003-9993issn
1532-821Xpii
S0003-9993(04)00009-7journal_volume
85pub_type
杂志文章abstract:OBJECTIVE:To evaluate radiation exposure to spinal interventionalists while performing transforaminal epidural steroid injections (TFESIs). DESIGN:Prospective study. SETTING:Multidisciplinary spine center. PARTICIPANTS:One hundred consecutive patients with either herniated nucleus pulposus (HNP) or lumbar spinal ste...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.32439
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To describe return to work (RTW) for motor vehicle accident (MVA) survivors with mild traumatic brain injury (MTBI) and to examine relationships between RTW and injury severity, cognitive impairment, social interaction, discharge disposition, and sociodemographics. DESIGN:Inception cohort assessed within 1 ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(99)90275-7
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To investigate the relations between changes in motor capacity (can do, in standardized environment), motor capability (can do, in daily environment), and motor performance (does do, in daily environment) among children with cerebral palsy (CP). DESIGN:Prospective longitudinal study. After baseline measureme...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2014.04.013
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To test the effectiveness of the GivMohr sling in reducing subluxation while providing joint compression through a flaccid limb, using the criterion standard of radiography for measuring subluxation. DESIGN:Anteroposterior 0 degree radiographs were taken of each subject: 1 of the unaffected shoulder and 3 of...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.apmr.2005.07.291
更新日期:2005-12-01 00:00:00
abstract::There is evidence that chronic cane, crutch, and wheelchair users are at increased risk for developing pain and functional compromise of the wrist and hand. This investigation examined the prevalence and risk factors for median mononeuropathy at the wrist in the postpoliomyelitis population. The medical records of 148...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/0003-9993(89)90008-7
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of isokinetic exercise versus a program of patient education on pain and function in older persons with knee osteoarthritis. DESIGN:A randomized, comparative clinical trial, with interventions lasting 8 weeks and evaluations of 12 weeks. SETTING:An outpatient Veterans Affairs Medical...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0003-9993(99)90032-1
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVES:To estimate the level of balance self-efficacy among community-dwelling subjects with stroke and to determine the relative importance of balance self-efficacy compared with functional walking capacity in predicting physical function and perceived health status. DESIGN:Secondary analysis of baseline, postint...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2005.11.017
更新日期:2006-03-01 00:00:00
abstract::Assessment of strength using motor scores derived from the standards of the American Spinal Injury Association (ASIA) was compared with assessment using motor scores based on biomechanical aspects of walking in the prediction of ambulatory performance. Measurements of strength, gait performance, and the energy expendi...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To present preliminary data on the health-related consequences for people with spinal cord injury (SCI) of participation in a prepaid, risk-based, managed care plan. DESIGN:Baseline data from a longitudinal interview survey. SETTING:Massachusetts. PARTICIPANTS:Subjects were 114 independently living adults ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(99)90257-5
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To determine the clinical validity of provocative sacroiliac joint (SIJ) maneuvers in making the diagnosis of sacroiliac joint syndrome (SIJS). DESIGN:Prospective constructive cohort study using sacroiliac joint block (SIJB) as the diagnostic gold standard. SETTING:Tertiary care center. PATIENTS:Consecutiv...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(98)90008-9
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:The ability to measure and visualize shape change (deformation) of a residual limb within and between prostheses is an important step toward improved prosthetic fit assessment. The objective was to develop measurement and visualization methods for below-knee residual limb soft tissue shape change after donnin...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(98)90355-0
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To investigate and identify functional differences of 4 microprocessor-controlled prosthetic knee joints (C-Leg, Hybrid Knee [also called Energy Knee], Rheo Knee, Adaptive 2). DESIGN:Tested situations were walking on level ground, on stairs and ramps; additionally, the fall prevention potentials for each des...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2009.12.014
更新日期:2010-04-01 00:00:00
abstract::To determine electrical criteria which might be helpful in the diagnosis of ulnar nerve entrapment at the elbow, clinical and electrodiagnostic features in 78 patients with suspected ulnar nerve entrapment at the elbow are described and compared to the results of sensory and motor conduction in the ulnar nerve in a co...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVE:To validate a novel assessment of inpatient physical activity. DESIGN:Prospective cohort study for the evaluation of a novel questionnaire for physical activity in geriatric inpatients. SETTING:German geriatric inpatient rehabilitation unit. PARTICIPANTS:Patients (N=96; 67 [72%] women; median age, 81y) wit...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2011.06.032
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To describe the neurologic outcomes of 29 spinal epidural abscess (SEA) patients after rehabilitation compared with a case-controlled traumatic spinal cord injury (TSCI) cohort. DESIGN:Five-year retrospective chart review. SETTING:University-affiliated surgical spine unit and inpatient rehabilitation progra...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2008.09.567
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:We investigated the treatment effects of a home-based rehabilitation program compared with clinic-based rehabilitation in patients with stroke. DESIGN:A single-blinded, 2-sequence, 2-period, crossover-designed study. SETTING:Rehabilitation clinics and participant's home environment. PARTICIPANTS:Individual...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2018.03.017
更新日期:2018-12-01 00:00:00
abstract::To determine effects of severe muscular dystrophy on the performance of dynamic exercise, cardiorespiratory responses to incremental work on a bicycle ergometer and isokinetic limb strength measurements were compared for 13 dystrophic boys and 13 normal, untrained boys. The dystrophic boys (D) were matched to the norm...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::All patients admitted during a 6-month period to an inpatient geriatric rehabilitation unit were started on a medication education program incorporated into the rehabilitation program and utilizing existing staff. Patients were evaluated at admission, discharge, 90-day, and 1 year follow-up, using an 8-point medicatio...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Chronic pain is a common clinical finding in spinal cord injury (SCI), with a reported incidence of between 45% and 90%. This figure was obtained by using nonstandardized pain evaluation and for mostly inpatient populations. Because of the shortcomings of previous investigations and the wide range of reported incidenc...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVES:To determine which outcome measures are best and least suited for assessing long-term functional outcome of individuals with traumatic brain injury (TBI) in the community. DESIGN:Survey of participants in the community an average of 5 years after TBI. A battery of outcome measures was given. SETTING:Commun...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2001.21525
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To determine the interrater reliability of the Donovan system for classification of pain in spinal cord injury (SCI) as well as the clinician-based usefulness of each of the classification criteria used in the Donovan system. DESIGN:Information pertinent to the Donovan system was provided incrementally by vi...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.33636
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To develop and test a new instrument to assess environmental barriers encountered by people with and without disabilities by using a questionnaire format. DESIGN:New instrument development. SETTING:A rehabilitation hospital and community. PARTICIPANTS:Two convenience samples: (1) 97 subjects, 50 with disab...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2003.09.027
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the change in the 6-minute walk test (6-MWT) distance relative to changes in key functional capacity measures after 16 weeks of exercise training in older patients (≥65y) who have heart failure with preserved ejection fraction (HFpEF). DESIGN:Prospective, randomized, single-blinded (by researcher...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.apmr.2016.08.481
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To investigate the ability of the Timed Up & Go test to identify patients with Parkinson's disease at risk for a fall. DESIGN:Cross-sectional cohort study. SETTING:Sixteen participating National Parkinson's Foundation Centers of Excellence. PARTICIPANTS:A query yielded a total of 2985 records (1828 men and...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2013.02.020
更新日期:2013-07-01 00:00:00
abstract::Stroke frequently results in psychologic distress and activity limitations across multiple domains of functioning. However, most stroke outcome measurement tools and clinical trial endpoints are narrowly focused on neurologic symptom status and physical aspects of functioning, and rarely assess other important compone...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.36838
更新日期:2002-12-01 00:00:00
abstract::The snapping scapula syndrome is an infrequently described source of shoulder discomfort characterized by painful, audible, and/or palpable abnormal scapulothoracic motion. The syndrome may be caused by skeletal or soft-tissue abnormalities that interfere with articulation between the scapula and the rib cage. Often, ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,评审
doi:10.1016/s0003-9993(97)90165-9
更新日期:1997-05-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on the provision of medical care. As the curve progresses and patients are discharged, the rehabilitation wave brings a high number of postacute COVID-19 patients suffering from physical, mental, and cognitive impairments threatening their re...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2020.09.372
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To show the possible effect of left- and right-side total hip arthroplasty (THA) on the ability to perform an emergency stop when driving a car. DESIGN:Inception cohort. SETTING:A driving simulator using an actual car cabin, specifically developed for the experiment, was used for testing driving ability. P...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章
doi:10.1016/j.apmr.2014.03.009
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To examine functional outcome and descriptive data of individuals with neoplastic spinal cord compression admitted to a rehabilitation unit. DESIGN:A 5-year review of consecutive patients admitted to a spinal cord injury rehabilitation unit with a diagnosis of neoplastic spinal cord compression. SETTING:A t...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(96)90276-2
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:To identify differences in health factors, neuromuscular attributes, and performance-based mobility among community-dwelling older adults with symptomatic lumbar spinal stenosis; and to determine which neuromuscular attributes are associated with performance-based measures of mobility. DESIGN:Cross-sectiona...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2017.02.028
更新日期:2017-07-01 00:00:00