Naltrexone maintenance for heroin dependence: uptake, attrition and retention.

Abstract:

:With naltrexone registered only recently in Australia in 1999, it is important to examine the rate of uptake of naltrexone treatment, early attrition and retention rates during treatment, in order to inform the way naltrexone is used in Australian practice. Of 317 people screened for the study, 97 participants were recruited post-withdrawal from opiates and were inducted to naltrexone after a period of at least 5 days of abstinence. While in treatment, participants received a 50-mg dose of naltrexone daily, with daily dispensing for the first 7 days, and weekly dispensing for the following 11 weeks. For the naltrexone-treated sample as a whole, the rate of uptake of naltrexone treatment was 30%, with 30% retained in treatment for the entire 12-week program. Attrition from treatment was found to be steady throughout the 12 weeks. The authors conclude that further research is required to improve withdrawal and naltrexone induction techniques and to improve medication compliance and treatment retention.

journal_name

Drug Alcohol Rev

journal_title

Drug and alcohol review

authors

Tucker T,Ritter A,Maher C,Jackson H

doi

10.1080/09595230412331289464

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

299-309

issue

3

eissn

0959-5236

issn

1465-3362

pii

1ULPHWXL46PQDJ8M

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验
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