Abstract:
:Brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are novel natriuretic peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP), BNP is also synthesized in and secreted from cardiocytes, but CNP is not expressed at significant levels in normal adult myocardium. Previous studies have indicated that the serum level and ventricular expression of the ANP gene were augmented in patients with heart failure. Recently, the serum level of BNP was also reported to increase in human heart failure. To examine whether or not the expression of these natriuretic peptides is regulated in ventricular myocardium in a concordant manner, we performed Northern blot analysis using total cellular RNA isolated from the diseased left ventricles of 30 cardiac transplant recipients with end-stage heart failure, seven ventricles from organ donors (control group), and two ventricles of artificially aborted 17- and 19-week-old fetuses. The levels of mRNAs encoding both BNP and ANP increased significantly (p less than 0.01) in the left ventricular myocardium from the patients with end-stage heart failure as compared with the control group. The levels of BNP mRNA correlated positively with those of ANP mRNA (r = 0.73, p less than 0.01) and negatively with those of sarcoplasmic reticulum Ca(2+)-ATPase mRNA (r = -0.66, p less than 0.01) in the left ventricular myocardium from the patients with heart failure. There was also a negative correlation between the levels of ANP and the sarcoplasmic reticulum Ca(2+)-ATPase mRNAs (r = -0.65, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Circ Resjournal_title
Circulation researchauthors
Takahashi T,Allen PD,Izumo Sdoi
10.1161/01.res.71.1.9subject
Has Abstractpub_date
1992-07-01 00:00:00pages
9-17issue
1eissn
0009-7330issn
1524-4571journal_volume
71pub_type
杂志文章abstract::Intracellular potassium activity in guinea pig left atria was measured using potassium ion-selective microelectrodes and conventional microelectrodes. The effects of extracellular potassium concentration and acetylcholine on both intracellular potassium activity and the relationship between the resting membrane potent...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.54.1.65
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abstract::Prolongation of the action potential has been postulated to be a major reason for the altered diastolic relaxation of the heart in patients with severe heart failure. To investigate the electrophysiological basis for this action potential prolongation in terminal heart failure, K+ currents were recorded in single vent...
journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1993-08-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.res.38.6.2
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-07 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.47.3.384
更新日期:1980-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.55.5.580
更新日期:1984-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.187005
更新日期:2009-03-27 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.RES.0000127621.54132.AE
更新日期:2004-05-28 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2016-06-24 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.306838
更新日期:2015-09-25 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.117.305784
更新日期:2015-07-03 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.77.6.1087
更新日期:1995-12-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.41.4.4
更新日期:1977-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.82.4.496
更新日期:1998-03-09 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.186064
更新日期:2009-03-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
doi:10.1161/01.RES.0000087542.26971.D4
更新日期:2003-08-22 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.5.403
更新日期:1999-09-03 00:00:00
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pub_type: 杂志文章
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更新日期:2004-08-20 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2020-02-14 00:00:00
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更新日期:1993-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.37.3.318
更新日期:1975-09-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.63.3.593
更新日期:1988-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.108.178335
更新日期:2009-02-13 00:00:00
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pub_type: 杂志文章
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更新日期:2003-01-10 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.79.2.317
更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-04-13 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.64.1.173
更新日期:1989-01-01 00:00:00