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One pot synthesis of thiazolodihydropyrimidinones and evaluation of their anticancer activity.

Abstract：

:2-(5-Arylfurfurylidene/5-nitrofurfurylidene)-5-aryl-7-(2,4-dichloro-5-fluorophenyl)-5H-thiazolo[2,3-b]-pyrimidin-2(1H)-ones 5 and 6 are synthesized by a novel three component reaction of 4,6-diarylpyrimidino-2(1H)-thiones 4, monochloroacetic acid, arylfurfuraldehydes and 5-nitro-2-furfuraldenediacetate, respectively. The newly synthesized compounds are characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. These compounds exhibited in vitro antitumour activity with moderate to excellent growth inhibition against a panel of 60 cell lines of leukemia, non-small cell lung cancer melanoma, ovarian cancer, prostate cancer and breast cancer.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Holla BS,Rao BS,Sarojini BK,Akberali PM

doi

10.1016/j.ejmech.2004.06.001

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

777-83

issue

9

eissn

0223-5234

issn

1768-3254

pii

S0223523404001138

journal_volume

39

pub_type

杂志文章

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