Abstract:
PURPOSE:Epinephrine added to local anesthetic agents for spinal anesthesia is frequently used to prolong the duration of anesthesia. Epinephrine stimulates the alpha-adrenoceptor, and it is known that the alpha2-adrenoceptor agonists have a central inhibitory effect. We investigated the effect of intrathecal epinephrine during propofol sedation with spinal anesthesia, using a bispectral index (BIS) monitor. METHODS:Twenty adult patients, scheduled for spinal anesthesia, were allocated to the control group ( n = 10) or epinephrine group ( n = 10). Patients in the control group received 14 mg of tetracaine, whereas the epinephrine group received 14 mg of tetracaine and 0.2 mg of epinephrine. Immediately after the pinprick test, propofol was administered at 0.5 mg x kg(-1) by infusion for the initial dose, then continuously at 2 mg x kg(-1) x h(-1) in both groups. BIS scores were recorded before subarachnoid block, and then every 5 min for 90 min after subarachnoid block. RESULTS:There were significant differences in the BIS score between the two groups at 45-55 min and at 60-70 min after subarachnoid block. CONCLUSION:Intrathecal epinephrine augments the sedative effect of propofol during spinal anesthesia.
journal_name
J Anesthjournal_title
Journal of anesthesiaauthors
Yotsui T,Kitamura A,Ogawa Rdoi
10.1007/s00540-004-0233-9subject
Has Abstractpub_date
2004-01-01 00:00:00pages
147-50issue
3eissn
0913-8668issn
1438-8359journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Clinical histological studies demonstrate that the distribution of natural killer (NK) cells, other immune cells and μ-opioid receptors (MOR) within cancer tissue can predict cancer prognosis. No clinical study has evaluated whether anesthetic technique influences immune cell and MOR expression within human ...
journal_title:Journal of anesthesia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00540-018-2554-0
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:Inhaled anesthetics increase the incidence of postoperative residual neuromuscular blockade, and the mechanism is still unclear. We have investigated the synergistic effect of low-concentration inhaled anesthetics and rocuronium on inhibition of the inward current of the adult-type muscle nicotinic acetylcholin...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1527-y
更新日期:2013-06-01 00:00:00
abstract::We present a life-threatening case of hemothorax resulting from right brachiocephalic vein perforation during right internal jugular vein catheterization. We considered that the guidewire had punctured the right brachiocephalic vein extraluminally and the catheter inserted over the guidewire had enlarged the size of t...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0696-1
更新日期:2009-01-01 00:00:00
abstract::Rectal luminal regional P(CO2) (Pr(CO2)) was compared with gastric luminal Pr(CO2) measured by automated air tonometry at intervals of 10 min in 20 children aged 6-16 years scheduled for elective surgery under general anesthesia. In 5 patients, measurement of rectal Pr(CO2) failed because of catheter-related problems....
journal_title:Journal of anesthesia
pub_type: 临床试验,杂志文章
doi:10.1007/s00540-006-0410-0
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:During perioperative care, the continuous measurement of blood pressure (BP) provides superior physiological monitoring compared to intermittent techniques, especially for patients with comorbid conditions such as severe obesity. The current study prospectively assesses the accuracy of a continuous, noninvas...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-014-1835-5
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Several reports indicate that a neutrophil elastase inhibitor, sivelestat, may have prophylactic efficacy against a systemic inflammatory response after cardiovascular surgery with cardiopulmonary bypass (CPB). We evaluated the clinical pulmonary and cardiac effects of sivelestat. METHODS:We performed a retros...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-008-0645-z
更新日期:2008-01-01 00:00:00
abstract::With the aim to optimize surgical safety, the World Health Organization (WHO) introduced the Surgical Safety Checklist (SSCL) in 2008. The SSCL has been piloted in many countries worldwide and shown to improve both safety attitudes within surgical teams and patient outcomes. In the study reported here we investigated ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-013-1737-y
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Increased glucose variability may be associated with worse outcomes in critically ill patients. Hyperinsulinemic normoglycemia provides intensive glucose control during surgery and may reduce glucose variability. Our objective was to compare glycemic variability between two methods of glucose control in cardiac...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-016-2295-x
更新日期:2017-04-01 00:00:00
abstract::We report an 83-year-old man with myasthenia gravis (MG) who developed respiratory depression after spinal anesthesia for transurethral laser enucleation of the prostate. He became less responsive after complained of dyspnea, with a decrease of SpO2 to 83% approximately 13 min after intrathecal administration of 0.5% ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02874-9
更新日期:2021-02-01 00:00:00
abstract::Pituitary apoplexy is a rare but potentially life-threatening clinical syndrome caused by the sudden enlargement of pituitary adenoma secondary to infarction and/or hemorrhage. It may be the first presentation of previously undiagnosed pituitary adenoma. Although various precipitating factors of pituitary apoplexy are...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-010-0929-y
更新日期:2010-06-01 00:00:00
abstract::The purpose of this study was to determine the mortality rate in 527 critically ill patients with multiple organ failure (MOF), treated in our ICU between August, 1986 and January, 1992, and to compare it with the results obtained in a group of patients studied who had been treated between October, 1978 and July, 1986...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02514648
更新日期:1994-09-01 00:00:00
abstract::Shortly after repair of a type A aortic dissection, resternotomy was required because of tamponade. During the exploration, it was discovered that the source of bleeding was in the right pleura. Collapse of the right lung was requested. A double-lumen tube would have necessitated changing the endotracheal tube (ETT) i...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1116-5
更新日期:2011-06-01 00:00:00
abstract::To study the effects of repeated ketamine administration (0: saline, 12.5, 25, and 50 mg·kg-1 every 3 days for a total of five times, subcutaneously) on the central muscarinic acetylcholine receptors (mAchRs), receptor binding assays of mAchR were carried out in the forebrain of mice, using [3H]quinuclidinyl benzilate...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/BF02479877
更新日期:1995-09-01 00:00:00
abstract::Admission on the day of surgery for elective cardiac and non-cardiac surgery has been established as a prevalent, critical practice. This approach realizes medical, logistical, psychological and fiscal benefits, and its success is predicated on an effective outpatient pre-operative evaluation. The establishment of a h...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2139-8
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess whether preanesthetic laboratory values can predict in-hospital mortality and morbidity in patients who have undergone burr hole craniostomy due to chronic subdural hematoma. METHODS:From January 2007 to February 2016, the records of 502 consecutive patients who under...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2259-1
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:It has been suggested that the different degrees of fade induced by nondepolarizing neuromuscular blocking agents in repetitive muscular contractions may be due to the varying affinities or binding kinetics of presynaptic nicotinic receptors. We compared the degree of fade induced by mivacurium, cisatracurium, ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s005400300024
更新日期:2003-01-01 00:00:00
abstract::The concentrations of extracellular glutamate (Glu), aspartate (Asp) and glycine (Gly) were measured by microdialysis method in the cortex and hippocampus before, during and after 15 min of total cerebral ischemia in dogs. The correlations between the concentrations of amino acids and the changes in EEG and evoked pot...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054030070334
更新日期:1993-07-01 00:00:00
abstract::In many anesthesia textbooks written in English, lidocaine, tetracaine, bupivacaine, ropivacaine, and chloroprocaine are listed as useful local anesthetics for spinal anesthesia. In contrast, T-cain is not included in these lists, even though it has been reported to be suitable for spinal anesthesia in Japan. T-cain w...
journal_title:Journal of anesthesia
pub_type: 杂志文章,评审
doi:10.1007/s00540-015-2066-0
更新日期:2015-10-01 00:00:00
abstract::Cardiac effects of sevoflurane (SE) with or without nitrous oxide were examined in the canine blood-perfused papillary muscle and sinoatrial node preparations. Although SE depressed developed tension (DT), mean arterial pressure (MAP) and heart rate of the donor dog (DHR) dose dependently, sinoatrial rate (SAR) was no...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054090030145
更新日期:1989-09-01 00:00:00
abstract::Bronchial thermoplasty (BT) is a recently introduced bronchoscopic treatment for patients with asthma refractory to pharmacotherapy. Intraprocedural sedation management is important for successful performance of BT. However, the results of general anesthesia in patients undergoing BT have not been well described. The ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-2485-9
更新日期:2018-06-01 00:00:00
abstract::We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulde...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-016-2228-8
更新日期:2016-12-01 00:00:00
abstract::Arthrogryposis multiplex congenita (AMC) consists of complex congenital anomalies characterized by multiple contractures. Anesthetic management of these patients requires special care: as this disease often progresses until dysfunction of multiple organ systems occur, it may have an impact on the anesthetic management...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1309-y
更新日期:2012-04-01 00:00:00
abstract::The incidence of noncardiac surgery in patients with the Fontan circulation has increased over the years due to the elongated life expectancy of these patients. In patients with the Fontan circulation, pulmonary blood flow is passive, so it is important to keep pulmonary vascular resistance low. One-lung ventilation (...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-012-1333-6
更新日期:2012-06-01 00:00:00
abstract::Somato-sympathetic reflex discharges (SSRDs) which were induced from the lumbar sympathetic truck elicited by train pulse stimulation of femoral nerves in anesthetized cats were examined during and after intravenous infusion of 1 mg.kg(-1).min(-1) of procaine. The infusion demonstrated that amplitudes were suppressed ...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s0054020060461
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:We aimed to compare retrospectively the rates of renal morbidity and mortality in surgical patients receiving 6% HES 130/0.4 to those receiving albumin. METHODS:From a Japanese nationwide medical database between 2014 and 2016, we identified adults who received HES 130/0.4 (HES group) or albumin (albumin group...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-020-02838-z
更新日期:2020-12-01 00:00:00
abstract::The effect-compartment concentration (C(e)) of a drug at a specific pharmacodynamic endpoint should be independent of the rate of drug injection. We used this assumption to derive an effect-compartment equilibrium rate constant (k(eo)) for propofol during induction of anesthesia, using a target controlled infusion dev...
journal_title:Journal of anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00540-005-0378-1
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:The general public's perceptions of anesthesia and the risks associated with it may be skewed. The outpatient preoperative appointment with an anesthesiologist allows for patient education regarding different anesthetic options and counseling regarding anxiety related to anesthesia and surgery. This study inves...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-018-02608-y
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:Volatile anesthetics affect the cardiovascular and immune systems. Toward a better understanding of the molecular mechanisms behind the modulation exerted by these agents, we focused on the effects of halothane and isoflurane on the activation of p38 mitogen-activated protein kinase (MAPK), which plays a critic...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-004-0237-5
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:In emergency situations, rescuers occasionally must secure the airway while the patient is in a position other than the ideal supine position. We hypothesized that the laryngeal mask airway Supreme(®) (Supreme) may be useful for emergent airway management in several positions and compared the utility of the Sup...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-011-1145-0
更新日期:2011-08-01 00:00:00
abstract::We experienced simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass in a 79-year-old woman with atherosclerotic angina. During manipulation of the tumor under cardiopulmonary bypass, the serum norepinephrine concentration increased to over seventy times the n...
journal_title:Journal of anesthesia
pub_type: 杂志文章
doi:10.1007/s00540-007-0549-3
更新日期:2007-01-01 00:00:00