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Prostate cancer detection and tumor characteristics in men with multiple biopsy sessions.

Abstract：

PURPOSES:To address prostate cancer (PCa) detection with respect to the number of biopsy sessions performed, to identify risk factors for detection after a negative biopsy, and to analyze the clinical characteristics of the detected tumors. SCOPE:Only biopsied men (sextant) were included. A total of 1011 biopsy sessions were carried out in 770 men; 172 underwent a second prostate biopsy and 51 a third biopsy. During the first biopsy round, 111 cancers were found (14.4%), 27 in the second (15.7%), and five during the third round (9.8%), P=0.156. Only high-grade PIN or atypia were identified as independent predictors or PCa detection in subsequent biopsies (P=0.008). A nonsignificant increase of clinically localized tumors, and a decrease of metastatic and poorly differentiated cases were found when more biopsy sessions were needed for detection. CONCLUSIONS:A nonsignificant trend to lower cancer detection rates and less clinical relevance of the tumors detected can be observed when more biopsy rounds are needed for detection.

journal_name

Prostate Cancer Prostatic Dis

journal_title

Prostate cancer and prostatic diseases

authors

Lujan M,Paez A,Santonja C,Pascual T,Fernandez I,Berenguer A

doi

10.1038/sj.pcan.4500730

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

238-42

issue

3

eissn

1365-7852

issn

1476-5608

pii

4500730

journal_volume

7

pub_type

杂志文章

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