Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.

Abstract:

:The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.

authors

Miyazaki K,Kaiho F,Inagaki A,Dohi M,Hazemoto N,Haga M,Hara H,Kato Y

doi

10.1248/cpb.40.1075

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

1075-6

issue

4

eissn

0009-2363

issn

1347-5223

journal_volume

40

pub_type

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