Abstract:
:Morphology has a crucial effect on productivity and the supply of substrate for cultures of filamentous fungi. However, cultivation parameters leading to the desired morphology are often chosen empirically as the mechanisms governing the processes involved are usually unknown. For coagulating microorganisms like Aspergillus niger the morphological development is considered to start with the aggregation of conidia right after inoculation. To elucidate the mechanism of this process, kinetic studies were carried out using an in-line particle size analyzer. Based on the data obtained from these experiments a model for conidial aggregation is proposed in this article. It consists of two separate aggregation steps. The first one takes place immediately after inoculation, but only leads to a small decrease of total particle concentration. Most suspended conidia aggregate after a second aggregation step triggered by germination and hyphal growth. Aggregation velocity of this second phase is linearly dependent on the particle growth rate.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Grimm LH,Kelly S,Hengstler J,Göbel A,Krull R,Hempel DCdoi
10.1002/bit.20130subject
Has Abstractpub_date
2004-07-20 00:00:00pages
213-8issue
2eissn
0006-3592issn
1097-0290journal_volume
87pub_type
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