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Classification of Farnsworth-Munsell 100-hue test results in the early treatment diabetic retinopathy study.

Abstract：

PURPOSE:To classify and describe clinically meaningful classes of color vision defects using pretreatment Farnsworth-Munsell 100-hue results from the Early Treatment Diabetic Retinopathy Study (ETDRS) patients using standard statistical techniques. DESIGN:The ETDRS was a randomized trial investigating retinal photocoagulation and oral aspirin in diabetic retinopathy. METHODS:Farnsworth-Munsell (FM) 100-hue test was successfully administered before initiation of study treatment in each eye of 2701 of the 3711 ETDRS patients. Test results were converted into a Fourier series, classified by cluster analysis in the deferred-treatment group of eyes, and verified in the immediate-treatment group of eyes as separate samples. RESULTS:Cluster analysis uncovered thirteen distinct patterns. Pattern A (51% or 1366 of the eyes) showed unimpaired hue discrimination and was comprised of younger patients with no or little macular edema. Pattern B eyes (10% or 262) showed generalized impairment of hue discrimination with no main axis defect. Patterns C (C1, C2, C3), comprising 26% (or 698) of the eyes, showed increasing severity of the yellow-blue diabetic retinopathy defect, associated with increasing mean age and increasing macular edema severity. Patterns D (D1, D2), comprising 6% (or 164) of the eyes, were similar to the C patterns but showed a stronger yellow-blue defect. Patterns E (E1, E2, E3), or approximately 2% (or 38) of the eyes and predominantly male, exhibited the expected pattern for congenital protan defect. Patterns F, G, and H, approximately 6% (or 153) of the eyes, showed distinct patterns of one-sided axes. The nomenclature is arbitrary. CONCLUSIONS:Cluster analysis of FM 100-hue test results has found 13 patterns of impaired hue discrimination, helpful in understanding color vision defects in diabetes mellitus.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Barton FB,Fong DS,Knatterud GL,ETDRS Research Group.

doi

10.1016/j.ajo.2004.02.009

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

119-24

issue

eissn

0002-9394

issn

1879-1891

pii

S0002939404001357

journal_volume

138

pub_type

临床试验,杂志文章,随机对照试验

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Classification of Farnsworth-Munsell 100-hue test results in the early treatment diabetic retinopathy study.