Abstract:
:Most, but not all, ion channels appear to obey the law of microscopic reversibility (or detailed balance). During the fitting of reaction mechanisms it is therefore often required that cycles in the mechanism should obey microscopic reversibility at all times. In complex reaction mechanisms, especially those that contain cubic arrangements of states, it may not be obvious how to achieve this. Three general methods for imposing microscopic reversibility are described. The first method works by setting the 'obvious' four-state cycles in the correct order. The second method, based on the idea of a spanning tree, works by finding independent cycles (which will often have more than four states) such that the order in which they are set does not matter. The third method uses linear algebra to solve for constrained rates.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Colquhoun D,Dowsland KA,Beato M,Plested AJdoi
10.1529/biophysj.103.038679subject
Has Abstractpub_date
2004-06-01 00:00:00pages
3510-8issue
6eissn
0006-3495issn
1542-0086pii
S0006-3495(04)74394-5journal_volume
86pub_type
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