Abstract:
:The revised model of coagulation has implications for therapy of both hemorrhagic and thrombotic disorders. Of particular interest to anesthesiologists is the management of clotting abnormalities before, during, and after surgery. Most hereditary and acquired coagulation factor deficiencies can be managed by specific replacement therapy using clotting factor concentrates. Specific guidelines have also been developed for perioperative management of patients using anticoagulant agents that inhibit platelet or coagulation factor functions. Finally, recombinant factor VIIa has been used off-label as a hemostatic agent in some surgical situations associated with excessive bleeding that is not responsive to conventional therapy.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Roberts HR,Monroe DM,Escobar MAdoi
10.1097/00000542-200403000-00036subject
Has Abstractpub_date
2004-03-01 00:00:00pages
722-30issue
3eissn
0003-3022issn
1528-1175journal_volume
100pub_type
杂志文章,评审相关文献
ANESTHESIOLOGY文献大全abstract::In view of evidence suggesting possible participation of cobalamin in cyanide metabolism, the effects of sodium nitroprusside (SNP) infusion on blood cyanide and plasma thiocyanate levels and serum vitamin B12 levels were examined in ten patients undergoing major orthopedic procedures. Whole blood cyanide concentratio...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198104000-00009
更新日期:1981-04-01 00:00:00
abstract::The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197705000-00008
更新日期:1977-05-01 00:00:00
abstract::Cardiac output and myocardial blood flow decrease dramatically in a dose-dependent pattern in the young lamb during isoflurane anesthesia. This raises important questions about the ability of the young lamb to increase myocardial performance if oxygen delivery were compromised by a decrease in oxygen content during an...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198911000-00020
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:One-lung ventilation (OLV) results in alveolar proinflammatory effects, whereas their extent may depend on administration of anesthetic drugs. The current study evaluates the effects of different volatile anesthetics compared with an intravenous anesthetic and the relationship between pulmonary and systemic ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e318214b9de
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Inhalation anesthetics may interfere with the synthesis or action of endothelium-derived vasoactive factors. We investigated the effects of desflurane, enflurane, halothane, isoflurane, and sevoflurane on the release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the isolated endoth...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199509000-00017
更新日期:1995-09-01 00:00:00
abstract::Hemodynamic changes during four anesthetic techniques were studied in 80 preterm neonates. Atropine, 0.02 mg/kg, and pancuronium, 0.1 mg/kg, were given intravenously to all patients, who were ventilated with oxygen and air. Each group of 20 patients then received 0.75% isoflurane, 0.5% halothane, 20 micrograms/kg fent...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198602000-00018
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:General anesthetics reduce neuron loss following focal cerebral ischemia in rodents. The relative efficacy of this action among different anesthetics clinically used for neuroprotection is uncertain. In addition, it remains unclear how anesthetics compare to neuroprotection afforded by mild hypothermia. This...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200005000-00024
更新日期:2000-05-01 00:00:00
abstract::Blood from 20 ASA physical status I patients collected before and after induction of anesthesia was used in vitro to reexamine the effects of nitrous oxide on the oxyhemoglobin dissociation curve and the response of the oxygen electrode. The preinduction P50 values with and without 70% N2O were 28.4 +/- 0.1 mmHg and 2...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198702000-00015
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:The spinal cord appears to be the site at which isoflurane suppresses movement that occurs in response to a noxious stimulus. In an attempt to localize its site of suppressant action, the authors determined the effect of isoflurane on dorsal horn neuronal responses to supramaximal noxious stimulation at end-...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199901000-00027
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Local anesthetics were suggested to have a potential for neurotoxicity in both clinical reports and laboratory experiments. Growing neurons have been shown to be susceptible to the toxic effects of local anesthetics in culture. These findings have generated the interest in factors that would rescue the neuro...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200209000-00017
更新日期:2002-09-01 00:00:00
abstract::Recovery from anesthesia was assessed in a controlled manner in 34 healthy student volunteers, using a psychomotor test battery 1 and 5 hours and a driving simulator 2, 4.5, and 7 hours after 3.5 minutes of anesthesia with halothane or enflurane combined with nitrous oxide and oxygen. Psychomotor performances remained...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197701000-00006
更新日期:1977-01-01 00:00:00
abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197504000-00011
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS:Forty patients scheduled ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200701000-00007
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidurally administered opioids on the ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200308000-00029
更新日期:2003-08-01 00:00:00
abstract::The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197609000-00013
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND:Some studies suggest that the orbicularis oculi is resistant to neuromuscular blocking drugs and behaves like laryngeal muscles. Others report little or no difference between the orbicularis oculi and the adductor pollicis. These discrepancies could be related to the exact site of recording. The purpose of t...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200107000-00019
更新日期:2001-07-01 00:00:00
abstract::The blood flow in the sciatic nerve of the rabbit was estimated from the wash out of intraneurally injected 133Xe. To avoid diffusion of the tracer into the surrounding muscular tissue, the nerve was covered by a gas-tight plastic film. Using this technique, the basal blood flow in the sciatic nerve was estimated to 3...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198501000-00002
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Ca2+-permeable non-N-methyl-D-aspartate receptors are found in the spinal dorsal horn and represent a presumptive target for glutamatergic transmission in nociceptive processing. This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200110000-00028
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that desflurane and isoflurane produce similar hemodynamic actions. This investigation examined the cardiovascular effects of desflurane and isoflurane in the presence or absence of dexmedetomidine, a highly selective alpha 2-adrenergic agonist that may be clinically useful as a p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199311000-00021
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Clonidine produces analgesia after spinal injection by activating alpha2-adrenergic receptors. Recently, clonidine has been demonstrated to increase spinal release of norepinephrine (NE) in vivo, in contrast to that anticipated by classic presynaptic autoinhibition. The purpose of the current study was to de...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200007000-00027
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Patients undergoing cardiac surgery employing cardiopulmonary bypass frequently require transfusion of homologous blood products and, therefore, are exposed to the risk of transfusions. Autologous platelet-rich plasma administration may reduce homologous transfusion and attendant risks. METHODS:In a blinded...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199309000-00018
更新日期:1993-09-01 00:00:00
abstract::The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198101000-00010
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Neurocognitive dysfunction is a common complication of cardiac surgery using cardiopulmonary bypass (CPB). Elucidating injury mechanisms and developing neuroprotective strategies have been hampered by the lack of a suitable long-term recovery model of CPB. The purpose of this study was to investigate neurolo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200112000-00031
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Perioperative thoracic epidural analgesia reduces stress response and pain scores and may improve outcome after cardiac surgery. This prospective, randomized trial was designed to compare the effectiveness of patient-controlled thoracic epidural analgesia with patient-controlled analgesia with intravenous mo...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200601000-00020
更新日期:2006-01-01 00:00:00
abstract::Using the open ventriculocisternal perfusion method, rates of cerebrospinal fluid (CSF) production and reabsorption by bulk flow were examined in dogs anesthetized with either enflurane (2.2%) in nitrogen (60-70%) and oxygen, or nitrous oxide (60-70%) and enflurane (less than 0.2%) in oxygen (controls). The mean rate ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198210000-00001
更新日期:1982-10-01 00:00:00
abstract::The neonatal heart is especially vulnerable to cardiac depression caused by halothane. The cause of this sensitivity is uncertain. Isolated, perfused, isovolumic, contracting neonatal rabbit hearts were studied using 31P NMR to determine whether changes in concentrations of high energy phosphates (HEP) or intracellula...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198708000-00013
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:The noble gas xenon (Xe) has been used as an inhalational anesthetic agent in clinical trials with little or no physiologic side effects. Like nitrous oxide, Xe is believed to exert minimal unwanted cardiovascular effects, and like nitrous oxide, the vapor concentration to achieve 1 minimum alveolar concentr...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200002000-00035
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Postherpetic neuralgia is one of the major complications of herpes zoster caused by the reactivation of varicella-zoster virus and is characterized by severe pain. The authors previously showed the association of a human major histocompatibility complex (MHC) haplotype with postherpetic neuralgia. This study...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200605000-00024
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Although previous studies have proposed that anesthetics may influence signal transduction systems, their effects on the beta-adrenoceptor-mediated system have not been fully characterized in vascular smooth muscle. The aim of this study was to determine how halothane and isoflurane affect beta-adrenoceptor-...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199811000-00022
更新日期:1998-11-01 00:00:00
abstract::In late 1846, following his successful public demonstrations of surgical anesthesia, Boston dentist William T. G. Morton selected Letheon as the commercial name for the ether-based "preparation" he had used to produce insensibility to pain. We have not identified a first-hand account of the coinage of Letheon. Althoug...
journal_title:Anesthesiology
pub_type: 历史文章,杂志文章
doi:10.1097/ALN.0000000000002969
更新日期:2019-12-01 00:00:00