Current concepts of hemostasis: implications for therapy.

Abstract:

:The revised model of coagulation has implications for therapy of both hemorrhagic and thrombotic disorders. Of particular interest to anesthesiologists is the management of clotting abnormalities before, during, and after surgery. Most hereditary and acquired coagulation factor deficiencies can be managed by specific replacement therapy using clotting factor concentrates. Specific guidelines have also been developed for perioperative management of patients using anticoagulant agents that inhibit platelet or coagulation factor functions. Finally, recombinant factor VIIa has been used off-label as a hemostatic agent in some surgical situations associated with excessive bleeding that is not responsive to conventional therapy.

journal_name

Anesthesiology

journal_title

Anesthesiology

authors

Roberts HR,Monroe DM,Escobar MA

doi

10.1097/00000542-200403000-00036

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

722-30

issue

3

eissn

0003-3022

issn

1528-1175

journal_volume

100

pub_type

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