Abstract:
:The migration of B lymphocytes into distinct microenvironments in secondary lymphoid tissues and maintenance of cells in these micro-domains is strictly structured and likely supports the proper regulation of immune responses to both foreign and self-antigens. Chemokines' and other chemoattactants' signals serve as signposts to direct cell migration. They signal cells through heptahelical receptors, which couple to heterotrimeric G proteins (G protein-coupled receptors or GPCRs). The regulation of the signals transduced through these receptors ultimately determines the positioning of cells in lymphoid tissues. A variety of mechanisms regulate GPCR signaling including a family of approximately 25 proteins termed regulators of G protein signaling (RGS). These proteins act as GTPase activating proteins for G alpha subunits and can also function as effector antagonists of specific G alpha subunits, thereby attenuating signaling through GPCRs such as chemokine receptors. RGS proteins possess some degree of receptor and G alpha subunit specificity. Thus, the particular spectrum of RGS proteins and their expression levels within a cell will determine the duration and magnitude of G protein signaling initiated by chemokines. In this review we illustrate the role RGS proteins have in regulating B cell signaling responses to chemoattractant stimuli during homeostasis as well as during an immune response.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Moratz C,Harrison K,Kehrl JHsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
27-35issue
1eissn
0004-069Xissn
1661-4917pii
4458journal_volume
52pub_type
杂志文章,评审abstract::The incidence of cutaneous malignant melanoma, tumors arising from melanocytes, has increased markedly over the past few years in many countries. Although early melanoma is curable through surgical excision, the prognosis of advanced melanoma is very poor, this tumor being resistant to current therapies. Thus there is...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-007-0043-5
更新日期:2007-11-01 00:00:00
abstract::In 47 serum samples obtained from 31 women immunized with D antigen of the Rh system the level of anti-Rh D antibodies was measured by the papain and antiglobulin tests and the IgG subclasses of anti-Rh antibodies were determined. If the antibodies were of the IgG1 subclass or if this subclass prevailed in the IgG sub...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::A simple classification of cytokines is presented. It is based on voluminous information available from published papers of many outstanding researchers of the cytokines and their receptors and/or summarized by experts in this field. The cytokines are divided into 7 families according to their receptor code. Such arra...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Adjuvant-induced arthritis in rats is a chronic inflammatory disease, widely used as an animal model for rheumatoid arthritis. In our study the effect of various fractions of dialyzable leukocyte extract (DLE): DLE I-molecular weight below 10 kDa (commercial preparation), DLE II-molecular weight below 5 kDa (suppresso...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER) stress-induced cytotoxicity, and antioxidant activity owing to their activity as free radical scavengers, inhibition of coenzyme Q synthesis, activation of antio...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-017-0459-5
更新日期:2017-08-01 00:00:00
abstract::When BALB/c mice were first infected with Rauscher murine leukemia virus (MuLV-R) and then superinfected with Herpes simplex virus type 2 (HSV-2) the inhibition of the evolution of splenomegaly was observed. The effect did not depend on the route of HSV-2 administration. Experiments in which potent anti-interferon ser...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Antibacterial, antifungal and antitumor activity of 15 newly synthetized compounds were investigated in vitro. These compounds were mainly 1-[4-pyridyl]-pyridinium salts, dipyridyl sulphides and corresponding sulphones. Antitumor activity was evaluated in a model of leukemia L1210, P388, Sarcoma 180, Ehrlich carcinoma...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused b...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::Peripheral blood T lymphocytes and T cell subsets were analyzed in 19 patients with chronic active hepatitis B virus infection. The T cell subpopulations were defined by indirect immuno-fluorescence using monoclonal antibodies, and additionally, natural killer cell activity against K 562 human erythroleukemic cell has...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::High-dose chemotherapy in conjunction with bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) is increasingly being used for treatment of patients with hematological malignancies. Residual tumor cells, resistant to high-dose chemoradiotherapy, are responsible for reccurence of the ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Lymphocytes of 6 patients with infectious mononucleosis were found to be capable of responding in mixed lymphocyte culture (MLC) to Epstein-Barr virus (EBV)--transformed lymphoblastoid cell lines and Raji cells, whereas their response to PWM-induced blasts and non-T cells was significantly depressed. This means that d...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::The influence of antibiotics and purine and pyrimidine analogues on cells forming rosettes EA and EAC was evaluated in vitro. At the same time pH of solutions of examined immunosuppressors was estimated and a series of experiments with a buffer of appropriate pH was carried out. It was estimated that the effect inhibi...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Although the precise mechanism is obscure, dysregulation of the signaling transduction pathway in microglia may enhance inflammation, lea...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-010-0069-y
更新日期:2010-04-01 00:00:00
abstract::Killed dysentery bacilli induce immunity in mice which can be transferred to other mice with serum. Spleen cells do not transfer this immunity, in contrast to spleen cells from mice immunized with live dysentery bacilli. The results of this and previous studies 5,17 suggest that immunity in mice infected with dysenter...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Lymphocytes cultured for three days with PHA or Con A were capable of inducing vigorous proliferation of autologous or allogeneic lymphocytes. Kinetics of the response varied with mitogen dose used for obtaining stimulating cells and with the ratio of stimulating to responder cells. A requirement for viable, mitogen-r...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The dry thermal glycation method was used to conjugate D-glucose and D-fructose with bovine serum albumin. Reactions were conducted at 50-104 degrees C for 30 min. Depending on temperature, different levels of substitution were achieved. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The availability of neoplastic cell lines with well defined growth characteristics has greatly facilitated study of the tumor phenotype, tumor progression and metastatic process. MmB16 cell line has been established in vitro from the B16 mouse melanoma serially passaged in C57BL/6 mice. From MmB16 cells two lectin-res...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Programmed cell death protein 1 (PD-1) and its ligand PD-L1 are critical for the regulation of T cell exhaustion and activity suppression. Tumor cells expressing immune checkpoints including PD-L1 escape monitoring of T cells from the host immune system. Checkpoint inhibitors are highly promising therapies that functi...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-020-00601-6
更新日期:2020-11-13 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-010-0096-8
更新日期:2010-12-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-010-0083-0
更新日期:2010-08-01 00:00:00
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journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::A suspension of resident peritoneal cells isolated from individual Balb/c mice was subjected to gradual separation into the cells adherent and nonadherent to glass. The isolated fast adherent fraction displayed regulatory properties in relation to spontaneous interferon synthesis. Depending on whether the cells come f...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The innate immune system is essential for the first line of host defense against micropathogens. In virus-infected cells, exposed viral nucleotides are sensed by pattern recognition receptors (PRRs), resulting in the induction of type I interferon. Retinoic acid-inducible gene-I-like receptors (RLRs) are a member of P...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-010-0107-9
更新日期:2011-02-01 00:00:00
abstract::The role of Epstein-Barr virus (EBV) in the biology and clinical characteristics of diffuse large B cell lymphoma (DLBCL) is still poorly defined. A new provisional entity EBV-positive DLBCL of the elderly has been described in Asian population. Its incidence and prognosis remains unknown in middle European patients. ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-015-0341-2
更新日期:2016-04-01 00:00:00
abstract::Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a considerable impact on the quality of life. Alterations in signalling pathways may contribute to the ongoing inflammation and proliferation in CRSwNP. The MEK1/2-ERK1/2 pathway transmits signals from many extracellular molecules to regula...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-014-0281-2
更新日期:2014-06-01 00:00:00
abstract::In the era of the Human Genome Project, quantitation of gene expression by tumor/host cells is of paramount importance to investigate gene patterns responsible for cancer development, progression and response/resistance to treatment. Quantitative real-time PCR (qrt-PCR) technology has recently reached a level of sensi...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::The occurrence of circulating immune complexes was studied in 28 patients suffering from uveitis. The presence of complexes was found in 18 patients including 6 out of 10 patients with iridocyclitis and in 12 out of 18 patients with chronic total uveitis. ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00