Rosuvastatin improves the atherogenic and atheroprotective lipid profiles in patients with hypertriglyceridemia.

Abstract:

BACKGROUND:We examined the effects of rosuvastatin treatment on triglyceride levels and lipid measures in a parallel-group multicenter trial (4522IL/0035) in patients with hypertriglyceridemia (Fredrickson Type IIb or IV). METHODS:After a 6-week dietary lead-in period while on a National Cholesterol Education Program step I diet, 156 patients with fasting triglyceride levels >/= 300 and < 800 mg/dl were randomized to 6 weeks of double-blinded treatment: once-daily rosuvastatin of 5, 10, 20, 40 or 80 mg or placebo. The primary end point was mean percentage change from baseline in total serum triglyceride levels at week 6 as determined by analysis of variance. RESULTS:Rosuvastatin at all doses produced significant mean reductions in triglycerides compared with placebo (-18 to -40 compared with +2.9%, P 5 mg. The occurrence of adverse events was generally low and not dose related, although some adverse events occurred more frequently in the rosuvastatin 80 mg group. CONCLUSIONS:Rosuvastatin reduced triglyceride levels and improved the overall atherogenic and atheroprotective lipid profiles in hypertriglyceridemic patients.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Hunninghake DB,Stein EA,Bays HE,Rader DJ,Chitra RR,Simonson SG,Schneck DW

doi

10.1097/00019501-200403000-00008

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

115-23

issue

2

eissn

0954-6928

issn

1473-5830

pii

00019501-200403000-00008

journal_volume

15

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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