A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary-stent placement.

Abstract:

BACKGROUND AND OBJECTIVES:The aim of this clinical study was to evaluate the safety of local delivery of a photosensitizer followed by photodynamic therapy (PDT), to determine its effectiveness in reducing in-stent restenosis. STUDY DESIGN/PATIENTS AND METHODS:Porfimer sodium was administered via a local delivery catheter to five coronary-stent implanted lesions followed by irradiation with a pulse laser. Coronary angiography (CAG) was performed at the baseline, after the procedure and at a 6-month follow-up. RESULTS:By the 18-month clinical follow-up, no adverse events such as photodermatosis, or myocardial ischemia had occurred. At the follow-up, no coronary embolization, dissection, or aneurysmal dilatation was observed in the CAG. In-stent diameter stenosis, late loss, and loss index were 19.16+/-8.20%, 0.37+/-0.18 mm, and 0.19+/-0.12, respectively. No in-stent restenosis was observed. CONCLUSIONS:This study suggests that PDT, with local delivery of Porfimer sodium, is safe and may be a feasible technique in preventing in-stent restenosis.

journal_name

Lasers Surg Med

authors

Usui M,Miyagi M,Fukasawa S,Hara T,Ueyama N,Nakajima H,Takata R,Sasame A,Tamura K,Naitou Y,Yamashina A

doi

10.1002/lsm.20018

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

235-41

issue

3

eissn

0196-8092

issn

1096-9101

journal_volume

34

pub_type

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